SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 PHE A 366
ILE A 347
PHE A 297
PHE A 413
 None
 0.88A 1fslB-4zzhA:
undetectable		 1fslB-4zzhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 6 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
 None
 0.29A 1yc2A-4zzhA:
23.3		 1yc2A-4zzhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 ALA A 262
ASN A 346
ILE A 347
ASP A 348
 None
 0.35A 1yc2D-4zzhA:
23.6		 1yc2D-4zzhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.49A 1yc2E-4zzhA:
20.4		 1yc2E-4zzhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 7 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
 None
 0.27A 1yc5A-4zzhA:
20.9		 1yc5A-4zzhA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 7 SER A 265
ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.53A 1yc5A-4zzhA:
20.9		 1yc5A-4zzhA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 PHE A 287
PRO A 288
ASP A 289
TYR A 301
 None
 1.08A 2aouB-4zzhA:
2.5		 2aouB-4zzhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 ALA A 262
ASN A 346
ILE A 347
ASP A 348
 None
 0.34A 2h4jA-4zzhA:
20.5		 2h4jA-4zzhA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.57A 2h4jA-4zzhA:
20.5		 2h4jA-4zzhA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		3 / 3 ARG A 276
GLN A 294
PRO A 293
 None
 0.93A 2qhfA-4zzhA:
undetectable		 2qhfA-4zzhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 LEU A 493
VAL A 258
ILE A 464
PHE A 329
 None
 0.93A 2weyB-4zzhA:
undetectable		 2weyB-4zzhA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 GLN A 352
ILE A 356
ASP A 348
SER A 265
 None
 1.02A 2xytE-4zzhA:
undetectable		 2xytE-4zzhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 6 VAL A 258
LEU A 450
ILE A 486
ILE A 437
 None
 0.93A 3gcsA-4zzhA:
undetectable		 3gcsA-4zzhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 6 PHE A 652
TYR A 642
VAL A 476
THR A 242
 None
 1.24A 3ltwA-4zzhA:
undetectable		 3ltwA-4zzhA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 12 PHE A 297
PHE A 413
LEU A 350
ILE A 270
ALA A 313
 None
 1.42A 4a83A-4zzhA:
undetectable		 4a83A-4zzhA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.24A 4e47A-4zzhA:
undetectable		 4e47A-4zzhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.25A 4e47B-4zzhA:
undetectable		 4e47B-4zzhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.22A 4e47C-4zzhA:
undetectable		 4e47C-4zzhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.26A 4jdsA-4zzhA:
undetectable		 4jdsA-4zzhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.27A 4jdsB-4zzhA:
undetectable		 4jdsB-4zzhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 12 CYH A 253
GLN A 461
VAL A 433
ILE A 257
LEU A 339
 None
 1.41A 4k38B-4zzhA:
undetectable		 4k38B-4zzhA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.51A 4rmjA-4zzhA:
27.0		 4rmjA-4zzhA:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 1.00A 4w5oA-4zzhA:
undetectable		 4w5oA-4zzhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 1.00A 4z4eA-4zzhA:
2.1		 4z4eA-4zzhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 1.01A 4z4gA-4zzhA:
2.2		 4z4gA-4zzhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 1.00A 5ki6A-4zzhA:
undetectable		 5ki6A-4zzhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 LEU A 228
LEU A 202
ILE A 194
THR A 196
 None
 0.96A 5ljbA-4zzhA:
undetectable		 5ljbA-4zzhA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 LEU A 250
CYH A 490
CYH A 501
LEU A 500
 None
 1.33A 5mafA-4zzhA:
undetectable		 5mafA-4zzhA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 6 TYR A 317
ILE A 387
ALA A 382
ARG A 384
 None
 1.10A 6hu9m-4zzhA:
undetectable
6hu9q-4zzhA:
undetectable		 6hu9m-4zzhA:
19.77
6hu9q-4zzhA:
17.09