SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		10 / 12 ALA A 142
TYR A 144
TYR A 170
ASP A 172
GLN A 174
GLU A 211
ASP A 213
GLU A 216
ARG A 250
ASP A 375
 None
 0.47A 1dy4A-4zzpA:
63.9		 1dy4A-4zzpA:
58.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		6 / 12 ALA A 142
TYR A 144
TYR A 170
ASP A 172
GLU A 211
THR A 246
 None
 0.97A 1dy4A-4zzpA:
63.9		 1dy4A-4zzpA:
58.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		4 / 5 HIS A 227
TRP A 373
ALA A 378
TRP A 382
 None
 0.58A 1dy4A-4zzpA:
63.9		 1dy4A-4zzpA:
58.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 10 PHE A 273
TYR A 309
VAL A 287
ASN A 140
LEU A 143
 None
 0.90A 1fe2A-4zzpA:
undetectable		 1fe2A-4zzpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		3 / 3 GLU A 216
ASN A 140
TRP A 382
 None
 1.30A 1r15C-4zzpA:
undetectable		 1r15C-4zzpA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		4 / 6 GLN A 318
ALA A 221
ALA A 223
THR A 225
 None
 1.00A 2xfhA-4zzpA:
undetectable		 2xfhA-4zzpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		4 / 6 THR A  96
GLN A  97
ILE A 103
SER A  98
 None
 1.29A 3peoG-4zzpA:
undetectable		 3peoG-4zzpA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		4 / 8 ASP A 213
GLY A 259
GLU A 216
ARG A 250
 None
 1.00A 3s3nA-4zzpA:
undetectable		 3s3nA-4zzpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 12 VAL A 323
GLY A 325
ILE A 331
GLY A 328
SER A 321
 None
 1.01A 3sufD-4zzpA:
undetectable		 3sufD-4zzpA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		4 / 6 PRO A  13
SER A  79
THR A  84
THR A  85
 None
 0.82A 3tneA-4zzpA:
undetectable		 3tneA-4zzpA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 11 GLY A 169
ALA A 164
GLY A 152
MET A 148
VAL A 367
 None
 1.33A 4c5lA-4zzpA:
undetectable		 4c5lA-4zzpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 9 GLY A 169
ALA A 164
GLY A 152
MET A 148
VAL A 367
 None
 1.31A 4c5lB-4zzpA:
undetectable		 4c5lB-4zzpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 10 GLY A 169
ALA A 164
GLY A 152
MET A 148
VAL A 367
 None
 1.34A 4c5lC-4zzpA:
undetectable		 4c5lC-4zzpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 10 GLY A 169
ALA A 164
GLY A 152
MET A 148
VAL A 367
 None
 1.31A 4c5lD-4zzpA:
undetectable		 4c5lD-4zzpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 10 GLY A 169
ALA A 164
GLY A 152
MET A 148
VAL A 367
 None
 1.32A 4c5nB-4zzpA:
undetectable		 4c5nB-4zzpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 12 SER A  98
GLY A  74
SER A   7
ASN A  76
VAL A  33
 None
 1.19A 4dx5B-4zzpA:
undetectable		 4dx5B-4zzpA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		3 / 3 ARG A 177
TRP A 191
GLY A 201
 None
 0.93A 4e7cA-4zzpA:
undetectable		 4e7cA-4zzpA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		9 / 9 ASN A 140
ALA A 142
TYR A 144
TYR A 170
ASP A 172
GLU A 211
ASP A 213
GLU A 216
TRP A 373
 None
 0.63A 4ipmA-4zzpA:
61.7		 4ipmA-4zzpA:
52.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		3 / 3 SER A 348
ASP A 258
GLN A 174
 None
 0.83A 4oltA-4zzpA:
undetectable
4oltB-4zzpA:
undetectable		 4oltA-4zzpA:
19.46
4oltB-4zzpA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		4 / 6 ALA A 245
ASP A 172
LEU A 377
SER A 194
 None
 1.15A 4ot2A-4zzpA:
undetectable		 4ot2A-4zzpA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		4 / 5 TYR A 170
SER A 371
ASP A 213
ASP A 261
 None
 1.13A 4qtuB-4zzpA:
undetectable		 4qtuB-4zzpA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		3 / 3 GLN A 174
SER A 348
ASP A 258
 None
 0.75A 4qwpA-4zzpA:
undetectable
4qwpB-4zzpA:
undetectable		 4qwpA-4zzpA:
19.46
4qwpB-4zzpA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		3 / 3 GLY A   4
ASP A  73
ASN A  76
 None
 0.60A 5jglA-4zzpA:
undetectable		 5jglA-4zzpA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 9 ILE A  83
LEU A 372
GLY A 104
ASN A 102
ALA A 142
 None
 1.33A 5x66C-4zzpA:
undetectable		 5x66C-4zzpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Dictyostelium
purpureum) 		5 / 12 GLY A 184
ASP A 149
GLY A 152
GLY A 169
ALA A  36
 PCA  A   1 ( 3.3A)
None
None
None
None
 1.08A 6nj9K-4zzpA:
undetectable		 6nj9K-4zzpA:
21.23