SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		4 / 7 HIS A 428
GLY A 429
TYR A 462
TYR A 473
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.8A)
 0.41A 1dmaA-4zzyA:
6.0		 1dmaA-4zzyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		4 / 7 HIS A 428
GLY A 429
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.53A 1dmaA-4zzyA:
6.0		 1dmaA-4zzyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		6 / 6 HIS A 428
GLY A 429
TYR A 462
ALA A 464
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.50A 1dmaB-4zzyA:
4.0		 1dmaB-4zzyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		4 / 5 LEU A 372
LEU A 404
LEU A 484
MET A 569
 None
 1.03A 2oaxF-4zzyA:
undetectable		 2oaxF-4zzyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		3 / 3 GLY A 429
TYR A 473
SER A 470
 D7N  A1584 (-3.8A)
D7N  A1584 (-3.8A)
D7N  A1584 (-2.7A)
 0.75A 2xatA-4zzyA:
2.1		 2xatA-4zzyA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		7 / 8 HIS A 428
GLY A 429
TYR A 462
ALA A 464
LYS A 469
SER A 470
TYR A 473
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
 1.02A 3u9hA-4zzyA:
18.6		 3u9hA-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		6 / 8 HIS A 428
GLY A 429
TYR A 462
SER A 470
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.93A 3u9hA-4zzyA:
18.6		 3u9hA-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		7 / 8 HIS A 428
GLY A 429
TYR A 462
ALA A 464
SER A 470
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.94A 3u9hB-4zzyA:
18.6		 3u9hB-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		6 / 8 HIS A 428
GLY A 429
TYR A 462
LYS A 469
SER A 470
TYR A 473
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
 1.08A 3u9hB-4zzyA:
18.6		 3u9hB-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		5 / 12 CYH A 367
HIS A 361
ILE A 242
LEU A 241
LEU A 486
 None
 1.10A 3vn2A-4zzyA:
undetectable		 3vn2A-4zzyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		5 / 6 HIS A 428
GLY A 429
TYR A 462
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.60A 4ae1A-4zzyA:
6.1		 4ae1A-4zzyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		5 / 5 HIS A 428
GLY A 429
TYR A 462
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.55A 4ae1B-4zzyA:
5.9		 4ae1B-4zzyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		6 / 8 HIS A 428
GLY A 429
ALA A 464
SER A 470
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.2A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.86A 4bjcA-4zzyA:
18.3		 4bjcA-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		6 / 8 HIS A 428
GLY A 429
TYR A 462
ALA A 464
LYS A 469
SER A 470
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
 0.96A 4bjcA-4zzyA:
18.3		 4bjcA-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		6 / 8 HIS A 428
GLY A 429
TYR A 462
ALA A 464
SER A 470
TYR A 473
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
 0.40A 4bjcA-4zzyA:
18.3		 4bjcA-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		7 / 7 HIS A 428
GLY A 429
TYR A 462
ALA A 464
SER A 470
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.64A 4hyfA-4zzyA:
19.5		 4hyfA-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		8 / 8 HIS A 428
GLY A 429
TYR A 462
ALA A 464
LYS A 469
SER A 470
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.90A 4hyfB-4zzyA:
19.6		 4hyfB-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		8 / 8 HIS A 428
GLY A 429
TYR A 462
ALA A 464
LYS A 469
SER A 470
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.58A 4hyfC-4zzyA:
19.6		 4hyfC-4zzyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		4 / 4 LEU A 333
LEU A 327
GLN A 274
GLU A 449
 None
 1.03A 4i41A-4zzyA:
undetectable		 4i41A-4zzyA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		9 / 11 HIS A 428
GLY A 429
TYR A 455
TYR A 462
ALA A 464
LYS A 469
SER A 470
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.46A 4rv6A-4zzyA:
44.9		 4rv6A-4zzyA:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		9 / 11 HIS A 428
GLY A 429
TYR A 455
TYR A 462
ALA A 464
LYS A 469
SER A 470
TYR A 473
GLU A 558
 D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
 0.47A 4rv6B-4zzyA:
45.0		 4rv6B-4zzyA:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		7 / 9 HIS A 428
SER A 430
ASN A 434
ILE A 438
TYR A 462
SER A 470
TYR A 473
 D7N  A1584 (-3.6A)
None
None
None
D7N  A1584 (-3.7A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
 0.46A 5ha9B-4zzyA:
43.8		 5ha9B-4zzyA:
45.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens) 		3 / 3 HIS A 311
LYS A 259
PHE A 313
 None
 1.41A 5klaA-4zzyA:
undetectable		 5klaA-4zzyA:
23.45