SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 242
PHE A 241
ARG A 388
LEU A 138
 None
 1.19A 1ea1A-5a08A:
undetectable		 1ea1A-5a08A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.27A 1p6kA-5a08A:
undetectable		 1p6kA-5a08A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.29A 1p6kB-5a08A:
undetectable		 1p6kB-5a08A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.32A 1rs6A-5a08A:
undetectable		 1rs6A-5a08A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 385
VAL A 387
TRP A 382
 None
 0.98A 1tkqA-5a08A:
undetectable		 1tkqA-5a08A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 267
ARG A 405
ASN A 416
 None
 0.94A 1xzxX-5a08A:
undetectable		 1xzxX-5a08A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.30A 1zzqA-5a08A:
undetectable		 1zzqA-5a08A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.33A 1zzqB-5a08A:
undetectable		 1zzqB-5a08A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.20A 1zzuA-5a08A:
undetectable		 1zzuA-5a08A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.31A 1zzuB-5a08A:
undetectable		 1zzuB-5a08A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 264
GLN A 154
ILE A 184
PHE A 176
 None
 1.12A 2jn3A-5a08A:
undetectable		 2jn3A-5a08A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 342
ALA A 393
ALA A 391
LEU A 371
 None
 0.90A 2wx2A-5a08A:
undetectable		 2wx2A-5a08A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 342
ALA A 393
ALA A 391
LEU A 371
 None
 0.91A 2wx2B-5a08A:
undetectable		 2wx2B-5a08A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 318
MET A 307
PHE A 323
 None
 1.09A 3g4lD-5a08A:
undetectable		 3g4lD-5a08A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 342
ALA A 393
ALA A 391
LEU A 371
 None
 0.99A 3khmA-5a08A:
undetectable		 3khmA-5a08A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.32A 3n62A-5a08A:
undetectable		 3n62A-5a08A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.29A 3n62B-5a08A:
undetectable		 3n62B-5a08A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.33A 3n66B-5a08A:
undetectable		 3n66B-5a08A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 145
SER A 144
GLU A 174
TRP A 204
 None
 0.94A 3sg9B-5a08A:
undetectable		 3sg9B-5a08A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 408
ASP A 425
ASP A 406
ASN A 272
 None
 1.03A 3vywC-5a08A:
undetectable		 3vywC-5a08A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 451
ASP A 355
TYR A 286
LEU A 359
 None
 1.22A 3wg7A-5a08A:
undetectable
3wg7C-5a08A:
undetectable
3wg7P-5a08A:
undetectable		 3wg7A-5a08A:
20.61
3wg7C-5a08A:
18.83
3wg7P-5a08A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 MET A 219
TYR A 215
GLU A 218
HIS A 236
 None
 1.26A 3zmdA-5a08A:
undetectable
3zmdB-5a08A:
undetectable		 3zmdA-5a08A:
17.10
3zmdB-5a08A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.34A 4kcnB-5a08A:
undetectable		 4kcnB-5a08A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 311
GLU A 312
TYR A 370
PHE A 309
 None
 1.41A 4twdA-5a08A:
undetectable
4twdE-5a08A:
undetectable		 4twdA-5a08A:
20.37
4twdE-5a08A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 311
GLU A 312
TYR A 370
PHE A 309
 None
 1.42A 4twdA-5a08A:
undetectable
4twdB-5a08A:
undetectable		 4twdA-5a08A:
20.37
4twdB-5a08A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 311
GLU A 312
TYR A 370
PHE A 309
 None
 1.43A 4twdG-5a08A:
undetectable
4twdH-5a08A:
undetectable		 4twdG-5a08A:
20.37
4twdH-5a08A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 311
GLU A 312
TYR A 370
PHE A 309
 None
 1.42A 4twdH-5a08A:
undetectable
4twdI-5a08A:
undetectable		 4twdH-5a08A:
20.37
4twdI-5a08A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 7 SER A 457
SER A 399
GLU A 459
GLU A 460
 None
 1.17A 4xzkA-5a08A:
undetectable		 4xzkA-5a08A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 119
LEU A 461
ILE A 452
PHE A 109
 None
 1.07A 5jw1A-5a08A:
undetectable		 5jw1A-5a08A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 411
GLU A 262
TRP A 348
 None
 1.27A 5odiD-5a08A:
undetectable		 5odiD-5a08A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 241
ASN A 172
ASP A 173
TRP A 204
 None
 1.35A 5vunB-5a08A:
undetectable		 5vunB-5a08A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 451
ASP A 355
TYR A 286
LEU A 359
 None
 1.21A 5z84A-5a08A:
undetectable
5z84C-5a08A:
undetectable
5z84P-5a08A:
undetectable		 5z84A-5a08A:
20.61
5z84C-5a08A:
18.83
5z84P-5a08A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 451
ASP A 355
TYR A 286
LEU A 359
 None
 1.22A 5zcoA-5a08A:
undetectable
5zcoC-5a08A:
undetectable
5zcoP-5a08A:
undetectable		 5zcoA-5a08A:
20.61
5zcoC-5a08A:
18.83
5zcoP-5a08A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 451
ASP A 355
TYR A 286
LEU A 359
 None
 1.22A 5zcpA-5a08A:
undetectable
5zcpC-5a08A:
undetectable
5zcpP-5a08A:
undetectable		 5zcpA-5a08A:
20.61
5zcpC-5a08A:
18.83
5zcpP-5a08A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 352
VAL A 354
LEU A 359
HIS A 248
 None
 1.03A 6dyoA-5a08A:
undetectable		 6dyoA-5a08A:
11.32