SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.16A 1bsxA-5a0kA:
undetectable		 1bsxA-5a0kA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.16A 1bsxB-5a0kA:
undetectable		 1bsxB-5a0kA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 LEU A 155
LEU A 200
LEU A 135
LEU A  78
LEU A 136
 None
 1.17A 1mx1C-5a0kA:
undetectable		 1mx1C-5a0kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 HIS A 133
ALA A 143
ALA A 195
ALA A 152
HIS A 149
 None
None
None
GOL  A1324 ( 4.1A)
GOL  A1324 ( 4.4A)
 1.01A 2gluB-5a0kA:
undetectable		 2gluB-5a0kA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.05A 2h77A-5a0kA:
undetectable		 2h77A-5a0kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.05A 2h79A-5a0kA:
undetectable		 2h79A-5a0kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		3 / 3 GLU A 238
ASP A 231
TYR A 180
 None
 0.86A 2yvlB-5a0kA:
undetectable		 2yvlB-5a0kA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		4 / 4 LEU A 132
PRO A 129
LEU A 112
ARG A 156
 None
None
None
GOL  A1324 (-3.1A)
 1.41A 3hcoA-5a0kA:
undetectable		 3hcoA-5a0kA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		4 / 6 ILE A 190
THR A 187
ALA A 161
THR A 158
 None
MG  A1322 ( 4.8A)
None
None
 0.94A 3mdrB-5a0kA:
undetectable		 3mdrB-5a0kA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		4 / 6 HIS A  35
GLU A  81
ASP A 134
ASP A  39
 None
 1.30A 3vywA-5a0kA:
undetectable		 3vywA-5a0kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 GLY A  96
PRO A 102
GLY A 101
GLY A 100
ASP A  91
 None
 1.13A 4b17A-5a0kA:
undetectable		 4b17A-5a0kA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		3 / 3 TYR A 235
THR A 251
GLU A 262
 None
 0.53A 4df3A-5a0kA:
undetectable		 4df3A-5a0kA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		3 / 3 TYR A 235
THR A 251
GLU A 262
 None
 0.52A 4df3B-5a0kA:
undetectable		 4df3B-5a0kA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.06A 4lnwA-5a0kA:
undetectable		 4lnwA-5a0kA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 ILE A 199
ALA A 300
LEU A 201
ILE A 304
PHE A 139
 None
 1.06A 4lnxA-5a0kA:
undetectable		 4lnxA-5a0kA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		4 / 5 GLY A 282
ARG A 280
GLU A 302
PHE A  20
 None
 0.95A 4r82A-5a0kA:
undetectable
4r82B-5a0kA:
undetectable		 4r82A-5a0kA:
20.77
4r82B-5a0kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 LEU A  83
ILE A  59
HIS A 311
ILE A 193
PHE A 308
 None
 1.22A 4rp8C-5a0kA:
1.1		 4rp8C-5a0kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 11 LEU A 151
TYR A 148
LEU A 155
LEU A 116
LEU A 136
 None
 0.97A 4wg0C-5a0kA:
undetectable
4wg0D-5a0kA:
undetectable
4wg0E-5a0kA:
undetectable		 4wg0C-5a0kA:
3.62
4wg0D-5a0kA:
3.62
4wg0E-5a0kA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 11 LEU A 151
TYR A 148
LEU A 155
LEU A 116
LEU A 136
 None
 0.96A 4wg0E-5a0kA:
undetectable
4wg0F-5a0kA:
undetectable
4wg0G-5a0kA:
undetectable		 4wg0E-5a0kA:
3.62
4wg0F-5a0kA:
3.62
4wg0G-5a0kA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 9 PHE A 308
ILE A 304
THR A 158
LEU A  86
LEU A  82
 None
 1.21A 4ze0A-5a0kA:
undetectable		 4ze0A-5a0kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 10 LEU A  77
ALA A  80
GLU A  81
ARG A 138
GLY A 197
 None
 1.31A 5dx3A-5a0kA:
undetectable		 5dx3A-5a0kA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 9 ARG A 184
ASN A 230
SER A 234
ARG A 237
ARG A 316
 MG  A1323 (-4.0A)
MG  A1323 (-3.5A)
MG  A1323 (-3.4A)
None
None
 0.93A 5dz2A-5a0kA:
33.3		 5dz2A-5a0kA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 9 ASN A 230
SER A 234
ARG A 237
ARG A 316
TYR A 317
 MG  A1323 (-3.5A)
MG  A1323 (-3.4A)
None
None
None
 0.73A 5dz2A-5a0kA:
33.3		 5dz2A-5a0kA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		6 / 9 ARG A 184
ASN A 230
SER A 234
ARG A 237
ARG A 316
TYR A 317
 MG  A1323 (-4.0A)
MG  A1323 (-3.5A)
MG  A1323 (-3.4A)
None
None
None
 0.91A 5dz2B-5a0kA:
33.3		 5dz2B-5a0kA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 9 ASP A  90
ARG A 184
ASN A 230
SER A 234
TYR A 317
 MG  A1321 (-3.3A)
MG  A1323 (-4.0A)
MG  A1323 (-3.5A)
MG  A1323 (-3.4A)
None
 1.08A 5dz2B-5a0kA:
33.3		 5dz2B-5a0kA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		6 / 10 ARG A 184
VAL A 188
ASN A 230
SER A 234
ARG A 316
TYR A 317
 MG  A1323 (-4.0A)
None
MG  A1323 (-3.5A)
MG  A1323 (-3.4A)
None
None
 0.67A 5ermA-5a0kA:
22.2		 5ermA-5a0kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 10 ASP A  90
ARG A 184
ASN A 230
ARG A 316
TYR A 317
 MG  A1321 (-3.3A)
MG  A1323 (-4.0A)
MG  A1323 (-3.5A)
None
None
 1.19A 5ermA-5a0kA:
22.2		 5ermA-5a0kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		6 / 9 ARG A 184
VAL A 188
ASN A 230
SER A 234
ARG A 316
TYR A 317
 MG  A1323 (-4.0A)
None
MG  A1323 (-3.5A)
MG  A1323 (-3.4A)
None
None
 0.67A 5ermB-5a0kA:
11.2		 5ermB-5a0kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		5 / 12 LEU A 132
PHE A 139
THR A 192
ALA A 196
LEU A 200
 None
 1.16A 5iepA-5a0kA:
undetectable		 5iepA-5a0kA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		4 / 5 ALA A 279
VAL A 222
PHE A  20
ILE A 304
 None
 1.06A 5of1B-5a0kA:
undetectable		 5of1B-5a0kA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5a0k LABDANE-RELATED
DITERPENE SYNTHASE
(Streptomyces
sp.) 		4 / 5 GLU A 198
HIS A 297
LEU A 212
VAL A 215
 None
 0.77A 6bc9A-5a0kA:
undetectable		 6bc9A-5a0kA:
9.52