SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 THR A 403
GLY A 400
LYS A 386
CYH A 357
GLN A 359
 None
 1.32A 2akeA-5a0mA:
undetectable		 2akeA-5a0mA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 375
ASP A 344
ALA A 345
ASP A 444
 None
MN  A1529 ( 2.7A)
None
None
 0.96A 3rodD-5a0mA:
undetectable		 3rodD-5a0mA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 508
LEU A 462
THR A 464
LEU A 485
ILE A 500
 None
 1.20A 3tbgD-5a0mA:
undetectable		 3tbgD-5a0mA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		4 / 8 MET A 358
LEU A 374
THR A 403
LEU A 373
 None
 0.94A 4ik6B-5a0mA:
undetectable		 4ik6B-5a0mA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 345
PHE A 416
LEU A 475
LEU A 428
ILE A 338
 None
 1.10A 4km2A-5a0mA:
undetectable		 4km2A-5a0mA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 412
GLY A 337
ALA A 336
SER A 437
 None
 0.89A 5f1aB-5a0mA:
undetectable		 5f1aB-5a0mA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 460
GLY A 446
LEU A 462
TRP A 441
LEU A 438
 None
 1.24A 5fhzC-5a0mA:
undetectable		 5fhzC-5a0mA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 334
ILE A 338
LEU A 462
ASP A 444
LEU A 340
 None
 1.46A 6r2eB-5a0mA:
undetectable		 6r2eB-5a0mA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5a0m INTRON-ENCODED
ENDONUCLEASE I-SCEI
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 334
ILE A 338
LEU A 462
ASP A 444
LEU A 340
 None
 1.48A 6r2eD-5a0mA:
undetectable		 6r2eD-5a0mA:
20.34