SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TRP A 240
LEU A 244
LYS A  99
 None
 1.39A 1yajK-5a0nA:
undetectable		 1yajK-5a0nA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 TRP A 240
PHE A 246
ARG A 100
ILE A 112
 None
 1.41A 3e7gC-5a0nA:
undetectable
3e7gD-5a0nA:
undetectable		 3e7gC-5a0nA:
17.76
3e7gD-5a0nA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ARG A 100
ILE A 112
TRP A 240
PHE A 246
 None
 1.47A 3ej8A-5a0nA:
undetectable
3ej8B-5a0nA:
undetectable		 3ej8A-5a0nA:
17.32
3ej8B-5a0nA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 TRP A 240
PHE A 246
ARG A 100
ILE A 112
 None
 1.39A 3ej8A-5a0nA:
undetectable
3ej8B-5a0nA:
undetectable		 3ej8A-5a0nA:
17.32
3ej8B-5a0nA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ARG A 100
ILE A 112
TRP A 240
PHE A 246
 None
 1.37A 3ej8C-5a0nA:
undetectable
3ej8D-5a0nA:
undetectable		 3ej8C-5a0nA:
17.32
3ej8D-5a0nA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 TRP A 240
PHE A 246
ARG A 100
ILE A 112
 None
 1.44A 3ej8C-5a0nA:
undetectable
3ej8D-5a0nA:
undetectable		 3ej8C-5a0nA:
17.32
3ej8D-5a0nA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A  63
VAL A 180
GLN A 179
PHE A 177
SER A 207
 MES  A1256 (-3.7A)
None
None
None
None
 1.14A 3iw1A-5a0nA:
undetectable		 3iw1A-5a0nA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLY A  98
HIS A 132
SER A 136
SER A 135
 None
 1.14A 6jmjA-5a0nA:
undetectable		 6jmjA-5a0nA:
18.10