SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 11 THR A  35
LEU A 405
VAL A 398
VAL A 431
VAL A  21
 None
 1.30A 1akdA-5a0tA:
undetectable		 1akdA-5a0tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 5 HIS A 377
HIS A  84
HIS A  89
HIS A 399
ASP A 205
 G  E   1 ( 3.9A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
ZN  A1457 (-3.5A)
None
 1.44A 1e9yB-5a0tA:
undetectable		 1e9yB-5a0tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 8 ASP A 205
THR A 207
ASP A 173
HIS A  89
HIS A 377
 None
C  E   0 ( 3.6A)
ZN  A1457 ( 2.7A)
ZN  A1457 (-3.5A)
G  E   1 ( 3.9A)
 1.49A 1ei6C-5a0tA:
undetectable		 1ei6C-5a0tA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 8 SER A 341
SER A 375
HIS A 373
LYS A 367
 C  E   0 ( 3.2A)
C  E   0 ( 2.5A)
C  E   0 ( 3.7A)
None
 1.22A 1eqbA-5a0tA:
undetectable
1eqbB-5a0tA:
undetectable		 1eqbA-5a0tA:
23.68
1eqbB-5a0tA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 8 SER A 341
SER A 375
HIS A 373
LYS A 367
 C  E   0 ( 3.2A)
C  E   0 ( 2.5A)
C  E   0 ( 3.7A)
None
 1.22A 1eqbA-5a0tA:
undetectable
1eqbB-5a0tA:
undetectable		 1eqbA-5a0tA:
23.68
1eqbB-5a0tA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 8 SER A 341
SER A 375
HIS A 373
LYS A 367
 C  E   0 ( 3.2A)
C  E   0 ( 2.5A)
C  E   0 ( 3.7A)
None
 1.22A 1eqbC-5a0tA:
undetectable
1eqbD-5a0tA:
undetectable		 1eqbC-5a0tA:
23.68
1eqbD-5a0tA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 8 SER A 341
SER A 375
HIS A 373
LYS A 367
 C  E   0 ( 3.2A)
C  E   0 ( 2.5A)
C  E   0 ( 3.7A)
None
 1.22A 1eqbC-5a0tA:
undetectable
1eqbD-5a0tA:
undetectable		 1eqbC-5a0tA:
23.68
1eqbD-5a0tA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 PHE A 174
GLY A 172
LEU A 383
LEU A 202
TYR A 387
 None
 1.38A 1fm6X-5a0tA:
undetectable		 1fm6X-5a0tA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 7 LEU A  19
THR A 163
GLY A  17
LEU A  14
 None
 0.85A 1gtiB-5a0tA:
undetectable		 1gtiB-5a0tA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 8 VAL A 431
LEU A 201
PRO A  23
VAL A 398
 None
 1.07A 1jtvA-5a0tA:
undetectable		 1jtvA-5a0tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		3 / 3 ASP A  88
HIS A 151
ASP A 205
 ZN  A1457 (-2.7A)
ZN  A1458 (-3.6A)
None
 0.80A 1nw5A-5a0tA:
3.0		 1nw5A-5a0tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 10 THR A  35
LEU A 405
VAL A 398
VAL A 431
VAL A  21
 None
 1.33A 1o76A-5a0tA:
undetectable		 1o76A-5a0tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		3 / 3 ASP A 173
HIS A 399
HIS A 377
 ZN  A1457 ( 2.7A)
ZN  A1457 (-3.5A)
G  E   1 ( 3.9A)
 0.63A 1oe1A-5a0tA:
undetectable		 1oe1A-5a0tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		3 / 3 ASP A 173
HIS A 399
HIS A 377
 ZN  A1457 ( 2.7A)
ZN  A1457 (-3.5A)
G  E   1 ( 3.9A)
 0.63A 1oe3A-5a0tA:
undetectable		 1oe3A-5a0tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 LEU A 383
THR A 171
ASP A 173
GLY A 400
HIS A 399
 None
None
ZN  A1457 ( 2.7A)
None
ZN  A1457 (-3.5A)
 1.34A 1v8bA-5a0tA:
3.6		 1v8bA-5a0tA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 LEU A 383
THR A 171
ASP A 173
GLY A 400
HIS A 399
 None
None
ZN  A1457 ( 2.7A)
None
ZN  A1457 (-3.5A)
 1.33A 1v8bD-5a0tA:
undetectable		 1v8bD-5a0tA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 ILE A 106
GLY A 107
GLY A  85
VAL A 131
ALA A 132
 None
 1.01A 1vptA-5a0tA:
undetectable		 1vptA-5a0tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 ILE A  30
GLY A  31
LEU A  62
LEU A  51
SER A 152
 C  E   0 ( 3.6A)
None
None
None
G  E   1 ( 4.4A)
 1.17A 1zq9A-5a0tA:
undetectable		 1zq9A-5a0tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 ILE A 115
HIS A 151
GLY A  85
ASP A 173
GLY A 172
 None
ZN  A1458 (-3.6A)
None
ZN  A1457 ( 2.7A)
None
 1.02A 1zz1C-5a0tA:
2.5		 1zz1C-5a0tA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		6 / 12 LEU A 405
ASP A 427
HIS A  89
GLY A  26
ASP A 173
GLY A 172
 None
None
ZN  A1457 (-3.5A)
None
ZN  A1457 ( 2.7A)
None
 1.31A 1zz1C-5a0tA:
2.5		 1zz1C-5a0tA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 VAL A 149
VAL A 159
THR A  35
VAL A  46
LEU A 405
 None
 1.17A 2cbrA-5a0tA:
undetectable		 2cbrA-5a0tA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 10 THR A  35
LEU A 405
VAL A 398
VAL A 431
VAL A  21
 None
 1.35A 2cp4A-5a0tA:
undetectable		 2cp4A-5a0tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 VAL A 149
ILE A 161
CYH A 144
VAL A 139
PHE A 146
 None
 1.25A 2ft9A-5a0tA:
undetectable		 2ft9A-5a0tA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 HIS A  89
HIS A 399
ILE A  30
HIS A  84
ASP A 205
 ZN  A1457 (-3.5A)
ZN  A1457 (-3.5A)
C  E   0 ( 3.6A)
ZN  A1458 (-3.6A)
None
 1.19A 2pgrA-5a0tA:
undetectable		 2pgrA-5a0tA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 11 ASP A  88
HIS A  89
HIS A 151
ASP A 173
HIS A 399
 ZN  A1457 (-2.7A)
ZN  A1457 (-3.5A)
ZN  A1458 (-3.6A)
ZN  A1457 ( 2.7A)
ZN  A1457 (-3.5A)
 0.64A 2q0jB-5a0tA:
11.5		 2q0jB-5a0tA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 11 HIS A 399
HIS A  84
ASP A 173
HIS A 377
HIS A 244
 ZN  A1457 (-3.5A)
ZN  A1458 (-3.6A)
ZN  A1457 ( 2.7A)
G  E   1 ( 3.9A)
None
 1.19A 2q0jB-5a0tA:
11.5		 2q0jB-5a0tA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		3 / 3 ASP A 173
HIS A 399
HIS A 377
 ZN  A1457 ( 2.7A)
ZN  A1457 (-3.5A)
G  E   1 ( 3.9A)
 0.64A 2xxgA-5a0tA:
undetectable		 2xxgA-5a0tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		3 / 3 ASP A 173
HIS A 399
HIS A 377
 ZN  A1457 ( 2.7A)
ZN  A1457 (-3.5A)
G  E   1 ( 3.9A)
 0.66A 2xxgC-5a0tA:
undetectable		 2xxgC-5a0tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		6 / 12 LEU A  44
ILE A 103
LEU A  97
ILE A 115
PHE A 146
VAL A 159
 None
 1.08A 2ygqA-5a0tA:
undetectable		 2ygqA-5a0tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 6 PHE A 146
LEU A  82
VAL A  46
VAL A 139
 None
 1.01A 2zawA-5a0tA:
undetectable		 2zawA-5a0tA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 ILE A  90
GLY A  49
CYH A  48
ILE A  70
LEU A  44
 None
 1.33A 3adsB-5a0tA:
undetectable		 3adsB-5a0tA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 10 ASP A  88
GLY A  26
GLY A  25
LEU A  24
VAL A 449
 ZN  A1457 (-2.7A)
None
None
None
None
 1.01A 3em4V-5a0tA:
undetectable		 3em4V-5a0tA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 10 ILE A 237
ASN A 332
ALA A 362
LEU A 318
LEU A 357
 None
 1.23A 3o02A-5a0tA:
undetectable
3o02B-5a0tA:
undetectable		 3o02A-5a0tA:
22.68
3o02B-5a0tA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 MET A 321
LEU A 318
ALA A 316
GLU A 313
ILE A 237
 None
None
C  E   3 ( 3.4A)
C  E   2 ( 3.8A)
None
 1.12A 3olsB-5a0tA:
undetectable		 3olsB-5a0tA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 7 ASP A 173
HIS A 377
ILE A  30
HIS A 399
 ZN  A1457 ( 2.7A)
G  E   1 ( 3.9A)
C  E   0 ( 3.6A)
ZN  A1457 (-3.5A)
 1.01A 3t01A-5a0tA:
undetectable		 3t01A-5a0tA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 GLY A  25
GLY A 428
LEU A 201
VAL A 398
ALA A 204
 None
 1.13A 3t7vA-5a0tA:
2.2		 3t7vA-5a0tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		3 / 3 ASP A  76
THR A 163
PRO A 164
 None
 0.62A 3tkgD-5a0tA:
undetectable		 3tkgD-5a0tA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 7 ASP A 155
THR A 186
SER A 108
THR A 111
 None
 0.77A 4ac9C-5a0tA:
2.3		 4ac9C-5a0tA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 10 HIS A  84
HIS A  86
ASP A  88
HIS A 151
HIS A 399
 ZN  A1458 (-3.6A)
ZN  A1458 (-3.5A)
ZN  A1457 (-2.7A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
 0.93A 4c1dB-5a0tA:
9.6		 4c1dB-5a0tA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 11 HIS A  84
HIS A  86
ASP A  88
HIS A 151
HIS A 399
 ZN  A1458 (-3.6A)
ZN  A1458 (-3.5A)
ZN  A1457 (-2.7A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
 0.94A 4c1fA-5a0tA:
10.4
4c1fB-5a0tA:
10.0		 4c1fA-5a0tA:
18.35
4c1fB-5a0tA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 9 HIS A  84
HIS A  86
ASP A  88
HIS A 151
HIS A 399
 ZN  A1458 (-3.6A)
ZN  A1458 (-3.5A)
ZN  A1457 (-2.7A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
 0.94A 4c1hA-5a0tA:
11.0		 4c1hA-5a0tA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 8 HIS A  86
ASP A  88
HIS A 151
HIS A 399
 ZN  A1458 (-3.5A)
ZN  A1457 (-2.7A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
 0.83A 4exsB-5a0tA:
9.9		 4exsB-5a0tA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 5 HIS A 377
HIS A  84
HIS A  89
HIS A 399
ASP A 205
 G  E   1 ( 3.9A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
ZN  A1457 (-3.5A)
None
 1.41A 4h9mA-5a0tA:
undetectable		 4h9mA-5a0tA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 4 ASP A 432
LEU A  14
ARG A  73
THR A 441
 None
 1.49A 4kjkA-5a0tA:
undetectable		 4kjkA-5a0tA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 4 GLY A 368
LEU A 225
PHE A 229
ILE A 337
 None
 0.97A 4xv2A-5a0tA:
undetectable		 4xv2A-5a0tA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 6 GLU A  29
GLY A  26
GLY A  25
ASP A 427
 None
 0.85A 5a06D-5a0tA:
undetectable		 5a06D-5a0tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 8 HIS A  86
ASP A  88
HIS A 151
HIS A 399
 ZN  A1458 (-3.5A)
ZN  A1457 (-2.7A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
 0.78A 5a5zA-5a0tA:
10.1		 5a5zA-5a0tA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		6 / 11 HIS A  84
HIS A  86
ASP A  88
HIS A  89
HIS A 151
HIS A 399
 ZN  A1458 (-3.6A)
ZN  A1458 (-3.5A)
ZN  A1457 (-2.7A)
ZN  A1457 (-3.5A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
 0.40A 5ayaA-5a0tA:
12.4		 5ayaA-5a0tA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 5 SER A 243
ALA A 242
HIS A  86
LEU A 114
 C  E   2 ( 2.8A)
C  E   3 ( 3.5A)
ZN  A1458 (-3.5A)
None
 1.48A 5dzkc-5a0tA:
1.3
5dzkq-5a0tA:
undetectable		 5dzkc-5a0tA:
19.00
5dzkq-5a0tA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 PRO A 397
HIS A  89
GLY A  26
ASP A 173
ASP A 205
 None
ZN  A1457 (-3.5A)
None
ZN  A1457 ( 2.7A)
None
 1.16A 5eeiA-5a0tA:
undetectable		 5eeiA-5a0tA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 PRO A 397
HIS A  89
GLY A  26
ASP A 173
ASP A 205
 None
ZN  A1457 (-3.5A)
None
ZN  A1457 ( 2.7A)
None
 1.14A 5eeiB-5a0tA:
undetectable		 5eeiB-5a0tA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 LEU A  44
VAL A 159
ALA A 158
HIS A  89
HIS A  84
 None
None
None
ZN  A1457 (-3.5A)
ZN  A1458 (-3.6A)
 1.12A 5km9B-5a0tA:
undetectable		 5km9B-5a0tA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		6 / 10 HIS A  84
HIS A  86
HIS A  89
HIS A 151
ASP A 173
HIS A 377
 ZN  A1458 (-3.6A)
ZN  A1458 (-3.5A)
ZN  A1457 (-3.5A)
ZN  A1458 (-3.6A)
ZN  A1457 ( 2.7A)
G  E   1 ( 3.9A)
 0.38A 5nzwA-5a0tA:
9.1		 5nzwA-5a0tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 10 HIS A  89
HIS A 399
HIS A  84
ASP A 173
HIS A 151
 ZN  A1457 (-3.5A)
ZN  A1457 (-3.5A)
ZN  A1458 (-3.6A)
ZN  A1457 ( 2.7A)
ZN  A1458 (-3.6A)
 1.09A 5nzwA-5a0tA:
9.1		 5nzwA-5a0tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 10 HIS A 151
HIS A  84
HIS A 377
ASP A 173
HIS A 399
 ZN  A1458 (-3.6A)
ZN  A1458 (-3.6A)
G  E   1 ( 3.9A)
ZN  A1457 ( 2.7A)
ZN  A1457 (-3.5A)
 0.94A 5nzwA-5a0tA:
9.1		 5nzwA-5a0tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 6 ARG A 261
THR A 294
ASP A 296
LEU A 295
 None
 1.15A 5tdzA-5a0tA:
1.7		 5tdzA-5a0tA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 5 ASP A 102
GLU A 116
ARG A 125
THR A 128
 None
 1.38A 5uxcA-5a0tA:
undetectable		 5uxcA-5a0tA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 12 PHE A  37
LEU A  82
ILE A 103
HIS A 170
LEU A 203
 None
 1.28A 5ycpA-5a0tA:
undetectable		 5ycpA-5a0tA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		4 / 8 HIS A  86
ASP A  88
HIS A 151
HIS A 399
 ZN  A1458 (-3.5A)
ZN  A1457 (-2.7A)
ZN  A1458 (-3.6A)
ZN  A1457 (-3.5A)
 0.88A 5zj8A-5a0tA:
10.0		 5zj8A-5a0tA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5a0t RIBONUCLEASE J
(Streptomyces
coelicolor) 		5 / 10 ILE A  45
LEU A 105
LEU A  82
LEU A  96
LEU A  97
 None
 0.96A 6f6nA-5a0tA:
undetectable
6f6nB-5a0tA:
undetectable		 6f6nA-5a0tA:
9.34
6f6nB-5a0tA:
9.38