SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 GLN A 721
HIS A 719
PRO A 723
 None
 0.96A 1d8cA-5a0zA:
undetectable		 1d8cA-5a0zA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A1084
ALA A 668
ALA A 672
VAL A1099
GLN A1116
 None
 1.29A 1hbpA-5a0zA:
undetectable		 1hbpA-5a0zA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 ARG A 362
ILE A 454
TRP A 458
 None
 1.16A 1m8eB-5a0zA:
undetectable		 1m8eB-5a0zA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 ASP A 695
HIS A 642
ASP A 702
 None
 0.87A 1nw5A-5a0zA:
undetectable		 1nw5A-5a0zA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 9 TYR A 351
LEU A 352
VAL A 707
ILE A 653
ILE A 678
 None
 1.18A 1q6iA-5a0zA:
undetectable		 1q6iA-5a0zA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 10 TYR A 351
LEU A 352
VAL A 707
ILE A 653
ILE A 678
 None
 1.39A 1q6iB-5a0zA:
undetectable		 1q6iB-5a0zA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 730
VAL A 733
PHE A 745
CYH A 743
LEU A1062
 None
 1.29A 1wsvB-5a0zA:
undetectable		 1wsvB-5a0zA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 8 ARG A 343
ALA A 651
GLU A 576
LEU A 646
 None
 0.92A 2bxgA-5a0zA:
undetectable		 2bxgA-5a0zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 ILE A 653
MET A 344
THR A 341
LEU A 340
 None
 1.01A 2einN-5a0zA:
undetectable
2einW-5a0zA:
undetectable		 2einN-5a0zA:
21.19
2einW-5a0zA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 9 LEU A 620
LEU A 680
ILE A 700
LEU A 599
ILE A 602
 None
 1.15A 2f78A-5a0zA:
undetectable		 2f78A-5a0zA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 9 LEU A 620
LEU A 680
ILE A 700
LEU A 599
ILE A 602
 None
 1.15A 2f78B-5a0zA:
undetectable		 2f78B-5a0zA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 9 LEU A 620
LEU A 680
ILE A 700
LEU A 599
ILE A 602
 None
 1.19A 2f7aB-5a0zA:
undetectable		 2f7aB-5a0zA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 THR A 681
ASP A 624
ASN A 694
ASP A 695
 None
 1.13A 2okcA-5a0zA:
undetectable		 2okcA-5a0zA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 4 SER A 480
GLY A 481
HIS A 853
ASP A 419
 None
 1.39A 2oxtC-5a0zA:
undetectable		 2oxtC-5a0zA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 ILE A 653
MET A 344
THR A 341
LEU A 340
 None
 0.94A 3ag1N-5a0zA:
3.7
3ag1W-5a0zA:
undetectable		 3ag1N-5a0zA:
21.19
3ag1W-5a0zA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 ARG A 362
ILE A 454
TRP A 458
 None
 1.09A 3e68A-5a0zA:
undetectable		 3e68A-5a0zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 ARG A 362
ILE A 454
TRP A 458
 None
 1.15A 3e6tB-5a0zA:
undetectable		 3e6tB-5a0zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 VAL A 404
HIS A 560
ILE A 397
LEU A 396
 None
 0.82A 3hegA-5a0zA:
undetectable		 3hegA-5a0zA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 ALA A 736
ARG A 705
LYS A 729
 None
 0.80A 3kp3B-5a0zA:
undetectable		 3kp3B-5a0zA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_F_P77F203_1
(PROTEIN S100-A4)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 9 LEU A1063
SER A 722
ILE A 730
CYH A 743
ASP A 747
 None
 1.37A 3m0wC-5a0zA:
0.2
3m0wD-5a0zA:
undetectable
3m0wE-5a0zA:
undetectable
3m0wF-5a0zA:
undetectable		 3m0wC-5a0zA:
8.98
3m0wD-5a0zA:
8.98
3m0wE-5a0zA:
8.98
3m0wF-5a0zA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 10 LEU A1063
SER A 722
ILE A 730
CYH A 743
ASP A 747
 None
 1.33A 3m0wA-5a0zA:
undetectable
3m0wB-5a0zA:
undetectable
3m0wI-5a0zA:
undetectable
3m0wJ-5a0zA:
undetectable		 3m0wA-5a0zA:
8.98
3m0wB-5a0zA:
8.98
3m0wI-5a0zA:
8.98
3m0wJ-5a0zA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 599
ILE A 403
ALA A 645
ALA A 703
ALA A 651
 None
 1.06A 3mdtB-5a0zA:
undetectable		 3mdtB-5a0zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 402
ALA A 645
GLU A 647
ALA A 703
ALA A 651
 None
 1.00A 3mdvB-5a0zA:
undetectable		 3mdvB-5a0zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 599
ALA A 645
GLU A 647
ALA A 703
ALA A 651
 None
 0.88A 3mdvB-5a0zA:
undetectable		 3mdvB-5a0zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 845
THR A 786
ILE A 844
ALA A 474
GLN A 470
 None
 0.94A 3nvkI-5a0zA:
undetectable		 3nvkI-5a0zA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 9 ILE A 795
ILE A 793
VAL A 831
ILE A 838
ILE A 835
 None
 1.19A 3p4wB-5a0zA:
undetectable		 3p4wB-5a0zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 10 ILE A 795
ILE A 793
VAL A 831
ILE A 838
ILE A 835
 None
 1.20A 3p4wD-5a0zA:
2.7		 3p4wD-5a0zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 10 ILE A 795
ILE A 793
VAL A 831
ILE A 838
ILE A 835
 None
 1.19A 3p4wE-5a0zA:
undetectable		 3p4wE-5a0zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 845
SER A 849
ASP A 464
PHE A 479
SER A 480
 None
 1.35A 3pfgA-5a0zA:
undetectable		 3pfgA-5a0zA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 865
LEU A 608
GLY A 511
PHE A 508
SER A 601
 None
 1.31A 3tbgA-5a0zA:
2.5		 3tbgA-5a0zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 865
LEU A 608
GLY A 511
PHE A 508
SER A 601
 None
 1.31A 3tbgC-5a0zA:
2.5		 3tbgC-5a0zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 HIS A 350
GLU A 401
LEU A 396
ASP A 399
 None
 1.45A 4cevA-5a0zA:
undetectable
4cevB-5a0zA:
undetectable		 4cevA-5a0zA:
17.29
4cevB-5a0zA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 ASP A 399
HIS A 350
GLU A 401
LEU A 396
 None
 1.46A 4cevA-5a0zA:
undetectable
4cevC-5a0zA:
undetectable		 4cevA-5a0zA:
17.29
4cevC-5a0zA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 HIS A 350
GLU A 401
LEU A 396
ASP A 399
 None
 1.41A 4cevD-5a0zA:
undetectable
4cevE-5a0zA:
undetectable		 4cevD-5a0zA:
17.29
4cevE-5a0zA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 HIS A 350
GLU A 401
LEU A 396
ASP A 399
 None
 1.42A 4cevE-5a0zA:
undetectable
4cevF-5a0zA:
undetectable		 4cevE-5a0zA:
17.29
4cevF-5a0zA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 HIS A 749
HIS A 744
TYR A 766
TYR A 726
 None
 1.32A 4df2A-5a0zA:
3.3		 4df2A-5a0zA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 696
LEU A 699
ILE A 700
LEU A 599
ILE A 635
 None
 1.14A 4dm8A-5a0zA:
undetectable		 4dm8A-5a0zA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 9 GLU A 867
GLY A 778
PRO A 501
GLU A 613
GLY A 497
 None
 1.41A 4fimA-5a0zA:
undetectable		 4fimA-5a0zA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 7 GLY A 617
ILE A 678
GLU A 606
GLN A 782
 None
 0.98A 4g0vA-5a0zA:
2.5		 4g0vA-5a0zA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 ARG A 934
GLU A 931
ARG A 935
 None
 0.97A 4mwvA-5a0zA:
undetectable		 4mwvA-5a0zA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 865
GLY A 511
ALA A 554
VAL A 550
VAL A 551
 None
 0.93A 4nkxD-5a0zA:
undetectable		 4nkxD-5a0zA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 SER A1067
ASP A 747
GLN A 685
 None
 0.69A 4oltA-5a0zA:
undetectable
4oltB-5a0zA:
1.6		 4oltA-5a0zA:
16.88
4oltB-5a0zA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 GLN A 685
SER A1067
ASP A 747
 None
 0.69A 4qwpA-5a0zA:
undetectable
4qwpB-5a0zA:
undetectable		 4qwpA-5a0zA:
16.75
4qwpB-5a0zA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 7 THR A 784
GLU A 773
GLY A 617
GLY A 770
 None
 0.82A 4rdxA-5a0zA:
undetectable		 4rdxA-5a0zA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 699
LEU A 696
GLU A 647
LEU A 649
LEU A 595
 None
 1.18A 4wg0H-5a0zA:
undetectable
4wg0I-5a0zA:
undetectable
4wg0J-5a0zA:
undetectable		 4wg0H-5a0zA:
2.41
4wg0I-5a0zA:
2.41
4wg0J-5a0zA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 595
GLU A 647
LEU A 649
LEU A 699
LEU A 696
 None
 1.00A 4wg0G-5a0zA:
undetectable
4wg0H-5a0zA:
undetectable
4wg0I-5a0zA:
undetectable		 4wg0G-5a0zA:
2.41
4wg0H-5a0zA:
2.41
4wg0I-5a0zA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 595
GLU A 647
LEU A 649
LEU A 699
LEU A 696
 None
 0.92A 4wg0K-5a0zA:
undetectable
4wg0L-5a0zA:
undetectable
4wg0M-5a0zA:
undetectable		 4wg0K-5a0zA:
2.41
4wg0L-5a0zA:
2.41
4wg0M-5a0zA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 7 GLU A 867
SER A 777
THR A 499
VAL A 883
 None
 1.06A 4wnvD-5a0zA:
undetectable		 4wnvD-5a0zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 7 GLY A1072
GLN A1073
TYR A 766
SER A 748
 None
 1.02A 4ws0A-5a0zA:
undetectable		 4ws0A-5a0zA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 8 GLY A1072
GLN A1073
TYR A 766
SER A 748
 None
 0.97A 4ws1A-5a0zA:
undetectable		 4ws1A-5a0zA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 7 TYR A 539
ASP A 518
ALA A 519
TYR A 540
 None
 1.21A 4zz8A-5a0zA:
undetectable		 4zz8A-5a0zA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 511
PRO A 592
ALA A 598
ILE A 602
LEU A 864
 None
 1.14A 5bw4B-5a0zA:
undetectable		 5bw4B-5a0zA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 10 GLY A 495
GLU A 612
GLY A 497
VAL A 876
ALA A 857
 None
 1.17A 5o96E-5a0zA:
undetectable
5o96F-5a0zA:
undetectable		 5o96E-5a0zA:
17.11
5o96F-5a0zA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 11 PRO A 676
ILE A1098
PHE A 740
SER A 713
LEU A 352
 None
 1.33A 5tiyA-5a0zA:
undetectable		 5tiyA-5a0zA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 861
ALA A 415
ALA A 393
ILE A 395
GLY A 405
 None
 1.03A 5veuB-5a0zA:
undetectable		 5veuB-5a0zA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 6 SER A 663
ARG A 355
ARG A 412
ASP A 438
 None
 1.30A 5zw4A-5a0zA:
undetectable		 5zw4A-5a0zA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		3 / 3 ILE A 379
THR A 378
PRO A 860
 None
 0.57A 6ncsA-5a0zA:
undetectable		 6ncsA-5a0zA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5a0z CHOLINE
TRIMETHYLAMINE LYASE
(Klebsiella
pneumoniae) 		4 / 7 ILE A 653
MET A 344
THR A 341
LEU A 340
 None
 0.95A 6nmfA-5a0zA:
2.7
6nmfJ-5a0zA:
undetectable		 6nmfA-5a0zA:
21.19
6nmfJ-5a0zA:
5.88