SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 4 HIS A 224
VAL A 218
ASN A 221
THR A 222
 None
 1.23A 1dy5A-5a12A:
undetectable		 1dy5A-5a12A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		5 / 12 GLY A  22
TYR A  64
LEU A  76
LEU A  91
LEU A  15
 None
 1.49A 1zgyA-5a12A:
undetectable		 1zgyA-5a12A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		5 / 12 LEU A 116
LEU A 185
ARG A 183
ILE A 112
GLY A  19
 HEM  A 250 (-3.8A)
AZI  A 251 ( 4.0A)
AZI  A 251 ( 3.8A)
None
None
 1.28A 2j7xA-5a12A:
undetectable		 2j7xA-5a12A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 7 GLU A 220
PHE A 200
ILE A 147
PHE A 208
 None
HEM  A 250 (-3.8A)
HEM  A 250 (-4.0A)
None
 0.88A 2qmzA-5a12A:
undetectable
2qmzB-5a12A:
undetectable		 2qmzA-5a12A:
21.32
2qmzB-5a12A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		5 / 12 LEU A 116
LEU A 185
ARG A 183
ILE A 112
GLY A  19
 HEM  A 250 (-3.8A)
AZI  A 251 ( 4.0A)
AZI  A 251 ( 3.8A)
None
None
 1.21A 4j26A-5a12A:
undetectable		 4j26A-5a12A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 5 PHE A 196
PRO A 148
VAL A 149
ALA A 194
 HEM  A 250 (-3.8A)
None
HEM  A 250 ( 4.4A)
None
 1.11A 4w5oA-5a12A:
undetectable		 4w5oA-5a12A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 5 PHE A 196
PRO A 148
VAL A 149
ALA A 194
 HEM  A 250 (-3.8A)
None
HEM  A 250 ( 4.4A)
None
 1.06A 4z4cA-5a12A:
undetectable		 4z4cA-5a12A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 5 PHE A 196
PRO A 148
VAL A 149
ALA A 194
 HEM  A 250 (-3.8A)
None
HEM  A 250 ( 4.4A)
None
 1.10A 4z4dA-5a12A:
undetectable		 4z4dA-5a12A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 5 PHE A 196
PRO A 148
VAL A 149
ALA A 194
 HEM  A 250 (-3.8A)
None
HEM  A 250 ( 4.4A)
None
 1.09A 4z4eA-5a12A:
undetectable		 4z4eA-5a12A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 8 LEU A 242
THR A 235
THR A 245
LEU A 246
 None
 0.66A 4z90F-5a12A:
undetectable
4z90G-5a12A:
undetectable
4z90H-5a12A:
undetectable
4z90I-5a12A:
undetectable
4z90J-5a12A:
undetectable		 4z90F-5a12A:
24.48
4z90G-5a12A:
24.48
4z90H-5a12A:
24.48
4z90I-5a12A:
24.48
4z90J-5a12A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 8 THR A 235
THR A 245
LEU A 246
LEU A 242
 None
 0.60A 4z90F-5a12A:
undetectable
4z90G-5a12A:
undetectable
4z90H-5a12A:
undetectable
4z90I-5a12A:
undetectable
4z90J-5a12A:
undetectable		 4z90F-5a12A:
24.48
4z90G-5a12A:
24.48
4z90H-5a12A:
24.48
4z90I-5a12A:
24.48
4z90J-5a12A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		5 / 9 ASP A 126
LEU A 127
LEU A 131
LEU A 116
GLU A 168
 None
None
HEM  A 250 ( 4.5A)
HEM  A 250 (-3.8A)
None
 1.19A 5dqfA-5a12A:
undetectable		 5dqfA-5a12A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 8 LEU A 175
GLY A 130
ALA A 129
SER A 132
 HEM  A 250 ( 4.7A)
None
None
None
 0.81A 5f1aA-5a12A:
undetectable		 5f1aA-5a12A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 7 LEU A 175
GLY A 130
ALA A 129
SER A 132
 HEM  A 250 ( 4.7A)
None
None
None
 0.72A 5f1aB-5a12A:
undetectable		 5f1aB-5a12A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 6 PHE A 196
PRO A 148
VAL A 149
ALA A 194
 HEM  A 250 (-3.8A)
None
HEM  A 250 ( 4.4A)
None
 1.13A 5t7bA-5a12A:
undetectable		 5t7bA-5a12A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5a12 CHLORITE DISMUTASE
(Magnetospirillum
sp.) 		4 / 5 ASN A 117
TYR A 186
GLY A 111
HIS A 187
 HEM  A 250 (-4.6A)
None
None
None
 1.01A 6gh9A-5a12A:
undetectable		 6gh9A-5a12A:
13.64