SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a1i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		4 / 8 PHE A 282
ASP A 291
GLY A 279
GLY A 278
 None
None
None
K  A 404 (-3.9A)
 0.90A 1ekjE-5a1iA:
undetectable
1ekjF-5a1iA:
undetectable		 1ekjE-5a1iA:
21.30
1ekjF-5a1iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		4 / 8 SER A  38
ASP A  39
GLU A  57
GLU A  70
 None
 1.12A 1knyA-5a1iA:
undetectable
1knyB-5a1iA:
1.7		 1knyA-5a1iA:
22.36
1knyB-5a1iA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.26A 1p7lC-5a1iA:
57.1		 1p7lC-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.44A 1p7lD-5a1iA:
57.2		 1p7lD-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.45A 1p7lC-5a1iA:
57.1		 1p7lC-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.26A 1p7lD-5a1iA:
57.2		 1p7lD-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.29A 1rg9A-5a1iA:
57.2		 1rg9A-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.45A 1rg9B-5a1iA:
57.2		 1rg9B-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.43A 1rg9A-5a1iA:
57.2		 1rg9A-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.29A 1rg9B-5a1iA:
57.2		 1rg9B-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.31A 1rg9C-5a1iA:
57.1		 1rg9C-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.43A 1rg9D-5a1iA:
57.2		 1rg9D-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.44A 1rg9C-5a1iA:
57.1		 1rg9C-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.30A 1rg9D-5a1iA:
57.2		 1rg9D-5a1iA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.20A 2obvA-5a1iA:
64.9		 2obvA-5a1iA:
85.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.11A 2p02A-5a1iA:
66.8		 2p02A-5a1iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		4 / 8 TRP A 300
ILE A 332
VAL A 314
GLY A 140
 None
 0.50A 3hjoB-5a1iA:
undetectable		 3hjoB-5a1iA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		3 / 3 LYS A 368
LYS A 367
PRO A  50
 None
 1.21A 4dv1L-5a1iA:
undetectable		 4dv1L-5a1iA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		5 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
K  A 403 ( 3.0A)
 0.32A 4k0bB-5a1iA:
27.0		 4k0bB-5a1iA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.28A 4kttA-5a1iA:
56.3		 4kttA-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.23A 4kttC-5a1iA:
56.1		 4kttC-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 12 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.66A 4ktvA-5a1iA:
55.9
4ktvB-5a1iA:
61.7		 4ktvA-5a1iA:
100.00
4ktvB-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 11 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.46A 4ktvC-5a1iA:
55.6
4ktvD-5a1iA:
62.0		 4ktvC-5a1iA:
100.00
4ktvD-5a1iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		5 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
K  A 403 ( 3.0A)
 0.33A 4l7iB-5a1iA:
26.4		 4l7iB-5a1iA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.21A 4ndnA-5a1iA:
56.7		 4ndnA-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.33A 4ndnB-5a1iA:
63.2		 4ndnB-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.17A 4ndnC-5a1iA:
56.6		 4ndnC-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.14A 4ndnD-5a1iA:
63.5		 4ndnD-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.25A 4odjA-5a1iA:
60.2		 4odjA-5a1iA:
56.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		3 / 3 PRO A 151
MET A 150
TYR A 271
 None
 0.80A 4qa0B-5a1iA:
undetectable		 4qa0B-5a1iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		3 / 3 PRO A 151
MET A 150
TYR A 271
 None
 0.78A 4qa0A-5a1iA:
undetectable		 4qa0A-5a1iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		3 / 3 PRO A 151
MET A 150
TYR A 271
 None
 0.87A 4qa2B-5a1iA:
undetectable		 4qa2B-5a1iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		4 / 5 ARG A 313
GLY A 193
ALA A 194
GLY A 336
 None
 0.89A 4u9uB-5a1iA:
undetectable		 4u9uB-5a1iA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.01A 5a1iA-5a1iA:
68.5		 5a1iA-5a1iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		4 / 4 VAL A 230
ALA A 157
ILE A 205
THR A 182
 None
 1.12A 5e4dB-5a1iA:
undetectable		 5e4dB-5a1iA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		4 / 7 PHE A 250
GLY A 254
GLY A  28
HIS A  29
 SAM  A 405 (-3.4A)
None
None
SAM  A 405 ( 3.6A)
 1.04A 5n9xA-5a1iA:
undetectable		 5n9xA-5a1iA:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 ALA A  55
GLU A  70
GLN A 113
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.21A 5t8sA-5a1iA:
56.9		 5t8sA-5a1iA:
56.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.19A 5t8sB-5a1iA:
54.9		 5t8sB-5a1iA:
56.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 7 ALA A  55
GLU A  70
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.28A 6fbnA-5a1iA:
60.3		 6fbnA-5a1iA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.23A 6fbnB-5a1iA:
54.6		 6fbnB-5a1iA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.09A 6fboA-5a1iA:
66.2		 6fboA-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 12 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.19A 6fbpA-5a1iA:
63.4
6fbpB-5a1iA:
56.7		 6fbpA-5a1iA:
100.00
6fbpB-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.26A 6fcbA-5a1iA:
64.1		 6fcbA-5a1iA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		8 / 8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.07A 6fcdA-5a1iA:
65.7		 6fcdA-5a1iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		7 / 7 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.04A 6g6rA-5a1iA:
66.9		 6g6rA-5a1iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		4 / 7 HIS A  89
HIS A 158
GLU A  27
GLU A 166
 None
 1.29A 6mn4F-5a1iA:
undetectable		 6mn4F-5a1iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens) 		4 / 7 GLY A 133
HIS A 326
GLU A 128
GLY A 358
 None
 0.98A 6n7fA-5a1iA:
undetectable		 6n7fA-5a1iA:
11.93