SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5a1k ADSEVERIN
(Homo
sapiens) 		3 / 3 GLN A  34
HIS A  37
PRO A  33
 None
 0.95A 1d8cA-5a1kA:
undetectable		 1d8cA-5a1kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5a1k ADSEVERIN
(Homo
sapiens) 		5 / 12 GLY A 234
GLY A 233
GLY A 163
PHE A 166
HIS A 141
 None
 1.00A 1dx6A-5a1kA:
undetectable		 1dx6A-5a1kA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5a1k ADSEVERIN
(Homo
sapiens) 		4 / 8 ASP A 349
GLY A  57
THR A  59
GLY A 335
 None
 0.85A 1jr1B-5a1kA:
undetectable		 1jr1B-5a1kA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5a1k ADSEVERIN
(Homo
sapiens) 		5 / 11 ASN A 270
ALA A 241
PHE A 343
LEU A 285
GLN A 292
 None
 1.14A 2h42A-5a1kA:
undetectable		 2h42A-5a1kA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5a1k ADSEVERIN
(Homo
sapiens) 		4 / 7 PHE A 283
GLY A 298
PHE A 272
PHE A 344
 None
 0.90A 3ko0D-5a1kA:
undetectable
3ko0E-5a1kA:
undetectable		 3ko0D-5a1kA:
17.30
3ko0E-5a1kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 5a1k ADSEVERIN
(Homo
sapiens) 		4 / 7 PHE A 283
GLY A 298
PHE A 272
PHE A 344
 None
 0.80A 3ko0M-5a1kA:
0.9
3ko0P-5a1kA:
0.9		 3ko0M-5a1kA:
17.30
3ko0P-5a1kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 5a1k ADSEVERIN
(Homo
sapiens) 		4 / 8 PHE A 283
GLY A 298
PHE A 272
PHE A 344
 None
 0.91A 3ko0O-5a1kA:
0.9
3ko0Q-5a1kA:
0.9		 3ko0O-5a1kA:
17.30
3ko0Q-5a1kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5a1k ADSEVERIN
(Homo
sapiens) 		4 / 7 GLY A 234
GLY A 233
PHE A 166
HIS A 141
 None
 0.68A 3o9mA-5a1kA:
undetectable		 3o9mA-5a1kA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5a1k ADSEVERIN
(Homo
sapiens) 		3 / 3 CYH A 165
ASN A 161
LYS A 143
 None
 1.36A 4k50A-5a1kA:
undetectable		 4k50A-5a1kA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5a1k ADSEVERIN
(Homo
sapiens) 		5 / 12 LEU A 220
GLY A 214
GLU A 212
VAL A 211
GLY A 233
 None
 1.20A 5f9zA-5a1kA:
undetectable		 5f9zA-5a1kA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5a1k ADSEVERIN
(Homo
sapiens) 		3 / 3 VAL A 211
SER A 215
TRP A 177
 None
 1.07A 5jwaA-5a1kA:
undetectable		 5jwaA-5a1kA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a1k ADSEVERIN
(Homo
sapiens) 		4 / 6 LEU A  29
PHE A  10
HIS A   7
PHE A  40
 None
 1.07A 5vkqA-5a1kA:
undetectable
5vkqB-5a1kA:
undetectable		 5vkqA-5a1kA:
11.48
5vkqB-5a1kA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a1k ADSEVERIN
(Homo
sapiens) 		4 / 6 PHE A  40
LEU A  29
PHE A  10
HIS A   7
 None
 1.08A 5vkqA-5a1kA:
undetectable
5vkqD-5a1kA:
undetectable		 5vkqA-5a1kA:
11.48
5vkqD-5a1kA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5a1k ADSEVERIN
(Homo
sapiens) 		5 / 12 GLN A  84
LEU A  89
GLY A  90
GLY A  91
PRO A  93
 None
 0.97A 5wyqB-5a1kA:
undetectable		 5wyqB-5a1kA:
22.32