SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA B 214
ILE B 213
LEU B 183
LEU B 142
PHE B 221
 None
None
None
None
GOL  B1321 (-3.8A)
 1.01A 1dtlA-5a1nB:
undetectable		 1dtlA-5a1nB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 ILE B 213
LEU A  72
LEU B 183
LEU B 142
PHE B 221
 None
None
None
None
GOL  B1321 (-3.8A)
 1.04A 1dtlA-5a1nB:
undetectable		 1dtlA-5a1nB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 SER B 219
HIS A  75
ILE A  78
VAL B 237
 None
 1.10A 1kb9A-5a1nB:
undetectable
1kb9C-5a1nB:
undetectable
1kb9D-5a1nB:
undetectable
1kb9E-5a1nB:
undetectable		 1kb9A-5a1nB:
17.95
1kb9C-5a1nB:
19.74
1kb9D-5a1nB:
20.66
1kb9E-5a1nB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 7 ILE A  99
THR A  98
TRP A 134
GLN A 137
 None
 1.28A 1kglA-5a1nA:
undetectable		 1kglA-5a1nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL B 148
LEU B 183
LEU B 138
LEU B 142
LEU B 135
 None
 0.96A 1mx1F-5a1nB:
undetectable		 1mx1F-5a1nB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE B 199
LEU B 112
LEU B 108
ILE B 122
LEU B 217
 None
 1.02A 2bdmA-5a1nB:
undetectable		 2bdmA-5a1nB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 6 ALA A  20
LEU A  19
ALA A 126
THR A 127
 None
 0.89A 3b6hA-5a1nA:
undetectable		 3b6hA-5a1nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 6 ALA A  20
LEU A  19
ALA A 126
THR A 127
 None
 0.89A 3b6hB-5a1nA:
undetectable		 3b6hB-5a1nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER B 219
VAL B 276
PHE B 216
VAL B 237
 None
 1.11A 3fhxB-5a1nB:
undetectable		 3fhxB-5a1nB:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 119
ILE A  78
ASP A  79
ARG B 215
ASP B 238
 None
 1.47A 4b9zA-5a1nA:
undetectable		 4b9zA-5a1nA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		4 / 7 PHE B 169
ALA B 126
THR B 195
LEU B 136
 None
 1.08A 4ejgA-5a1nB:
undetectable		 4ejgA-5a1nB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		4 / 7 PHE B 185
PHE B 169
THR B 195
LEU B 136
 None
 1.09A 4ejgA-5a1nB:
undetectable		 4ejgA-5a1nB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		4 / 7 PHE B 199
GLY B 184
LEU B 112
PHE B 216
 None
 0.90A 4ejjD-5a1nB:
undetectable		 4ejjD-5a1nB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 6 ASN A  52
ARG B 215
TYR A  68
LEU A 119
 None
 1.33A 4f8yA-5a1nA:
undetectable
4f8yB-5a1nA:
undetectable		 4f8yA-5a1nA:
20.85
4f8yB-5a1nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU B 108
LEU B 183
ILE B 122
ILE B 201
PHE B 216
 None
 1.00A 4odrA-5a1nB:
undetectable
4odrB-5a1nB:
undetectable		 4odrA-5a1nB:
20.42
4odrB-5a1nB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 11 LEU A  82
GLY A  16
LEU A  19
ALA A  59
PHE A 160
 None
 1.26A 4wnuC-5a1nA:
undetectable		 4wnuC-5a1nA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 211
GLY B 209
VAL A 113
ASP A  79
ILE A  78
 None
 0.95A 5ehgC-5a1nB:
undetectable		 5ehgC-5a1nB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 ASN A 131
TRP A 150
PHE A 151
THR A  96
 None
 1.19A 5hqaA-5a1nA:
undetectable		 5hqaA-5a1nA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		4 / 5 HIS B 225
ILE B 233
PHE B 218
ALA B 277
 None
None
GOL  B1321 ( 4.9A)
None
 1.22A 5msdA-5a1nB:
undetectable		 5msdA-5a1nB:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 211
GLY B 209
VAL A 113
ASP A  79
ILE A  78
 None
 0.96A 5wz1A-5a1nB:
undetectable		 5wz1A-5a1nB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 211
GLY B 209
VAL A 113
ASP A  79
ILE A  78
 None
 0.95A 5wz1C-5a1nB:
undetectable		 5wz1C-5a1nB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 211
GLY B 209
VAL A 113
ASP A  79
ILE A  78
 None
 0.95A 5wz1D-5a1nB:
undetectable		 5wz1D-5a1nB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 211
GLY B 209
VAL A 113
ASP A  79
ILE A  78
 None
 0.97A 5wz1E-5a1nB:
undetectable		 5wz1E-5a1nB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 211
GLY B 209
VAL A 113
ASP A  79
ILE A  78
 None
 0.95A 5wz1F-5a1nB:
undetectable		 5wz1F-5a1nB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 211
GLY B 209
VAL A 113
ASP A  79
ILE A  78
 None
 0.95A 5wz1G-5a1nB:
undetectable		 5wz1G-5a1nB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens) 		3 / 3 ALA B 277
PHE B 218
GLN B 223
 None
GOL  B1321 ( 4.9A)
GOL  B1321 (-3.2A)
 0.82A 6eceA-5a1nB:
undetectable		 6eceA-5a1nB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 LYS A  88
SER A  94
SER A  97
 None
 1.16A 6gbfA-5a1nA:
undetectable		 6gbfA-5a1nA:
18.14