SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		4 / 5 LEU A 181
GLU A 163
ALA A 197
LEU A 199
 None
 1.16A 1eta1-5a21A:
undetectable		 1eta1-5a21A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		4 / 5 LEU A 181
GLU A 163
ALA A 197
LEU A 199
 None
 1.14A 1eta2-5a21A:
undetectable		 1eta2-5a21A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		4 / 6 LEU A 181
GLU A 163
ALA A 197
LEU A 199
 None
 1.18A 1etb1-5a21A:
undetectable		 1etb1-5a21A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		5 / 10 LEU A 199
ALA A 197
MET A 165
LEU A  37
HIS A 146
 None
 1.19A 1pcgA-5a21A:
undetectable		 1pcgA-5a21A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		5 / 10 LEU A 199
ALA A 197
MET A 165
LEU A  37
HIS A 146
 None
 1.20A 1pcgB-5a21A:
undetectable		 1pcgB-5a21A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		4 / 7 SER A 312
TYR A 286
ASN A 290
LEU A 288
 None
 1.45A 3lslA-5a21A:
undetectable
3lslD-5a21A:
undetectable		 3lslA-5a21A:
21.37
3lslD-5a21A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		5 / 12 LEU A 199
ALA A 197
MET A 165
LEU A  37
HIS A 146
 None
 1.21A 3olsB-5a21A:
undetectable		 3olsB-5a21A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		4 / 7 LYS A 261
LEU A 257
SER A 255
LYS A 140
 None
 0.88A 4tvtA-5a21A:
undetectable		 4tvtA-5a21A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		5 / 10 LEU A 199
ALA A 197
MET A 165
LEU A  37
HIS A 146
 None
 1.19A 5hyrA-5a21A:
undetectable		 5hyrA-5a21A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5a21 PORTAL PROTEIN
(Bacillus
phage
SPP1) 		3 / 3 TYR A 208
LEU A 181
ASP A  39
 None
 0.79A 5zv2B-5a21A:
undetectable		 5zv2B-5a21A:
12.08