SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens) 		4 / 7 SER A 146
ASP A 147
GLU A  67
GLU A  59
 None
 1.01A 1knyA-5a2eA:
undetectable
1knyB-5a2eA:
undetectable		 1knyA-5a2eA:
21.75
1knyB-5a2eA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens) 		4 / 8 SER A 146
ASP A 147
GLU A  67
GLU A  59
 None
 1.09A 1knyA-5a2eA:
undetectable
1knyB-5a2eA:
undetectable		 1knyA-5a2eA:
21.75
1knyB-5a2eA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens) 		5 / 12 ALA A  78
LEU A 127
ALA A 151
VAL A 153
ALA A  94
 None
 0.94A 1sa1A-5a2eA:
undetectable
1sa1B-5a2eA:
undetectable		 1sa1A-5a2eA:
19.14
1sa1B-5a2eA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens) 		5 / 12 ALA A  78
LEU A 127
ALA A 151
VAL A 153
ALA A  94
 None
 0.96A 1sa1C-5a2eA:
undetectable
1sa1D-5a2eA:
undetectable		 1sa1C-5a2eA:
19.14
1sa1D-5a2eA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens) 		4 / 7 SER A  55
SER A  51
SER A  52
TRP A 238
 None
 1.04A 2cmlA-5a2eA:
undetectable		 2cmlA-5a2eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens) 		4 / 8 SER A  55
SER A  51
SER A  52
TRP A 238
 None
 1.02A 2cmlC-5a2eA:
undetectable		 2cmlC-5a2eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens) 		4 / 8 SER A  55
SER A  51
SER A  52
TRP A 238
 None
 1.00A 2cmlD-5a2eA:
undetectable		 2cmlD-5a2eA:
20.91