SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 GLY A 113
GLY A 114
SER A 200
PHE A 324
HIS A 416
 None
 0.94A 1dx6A-5a2gA:
42.8		 1dx6A-5a2gA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		4 / 5 PHE A 360
TYR A 364
LEU A 401
ASP A 371
 None
 1.38A 1dz6A-5a2gA:
undetectable		 1dz6A-5a2gA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 GLY A 114
TYR A 127
SER A 200
PHE A 324
HIS A 416
 None
 0.93A 1maaC-5a2gA:
37.4		 1maaC-5a2gA:
28.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 GLY A 114
SER A 200
LEU A 233
PHE A 379
HIS A 416
 None
 0.90A 1mx1C-5a2gA:
38.3		 1mx1C-5a2gA:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 GLY A 114
SER A 200
LEU A 233
PHE A 379
HIS A 416
 None
 0.89A 1mx1F-5a2gA:
38.0		 1mx1F-5a2gA:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 10 GLY A 113
GLY A 114
SER A 200
PHE A 324
HIS A 416
 None
 0.98A 1w76B-5a2gA:
42.6		 1w76B-5a2gA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 ARG A 380
ILE A 224
VAL A 317
GLU A 475
ASP A 491
 None
 1.24A 2qeoA-5a2gA:
undetectable		 2qeoA-5a2gA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		4 / 7 GLU A 123
GLY A 114
GLN A 199
ILE A 420
 None
 1.02A 2qmzA-5a2gA:
3.2
2qmzB-5a2gA:
3.2		 2qmzA-5a2gA:
18.71
2qmzB-5a2gA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		4 / 7 LEU A 248
ALA A 272
LEU A 269
PHE A  42
 None
 1.00A 2vcvG-5a2gA:
undetectable		 2vcvG-5a2gA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		4 / 8 THR A 377
TYR A 498
GLY A 322
ALA A 325
 None
 0.67A 3jusA-5a2gA:
undetectable		 3jusA-5a2gA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		4 / 8 THR A 377
TYR A 498
GLY A 322
ALA A 325
 None
 0.67A 3jusA-5a2gA:
undetectable		 3jusA-5a2gA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 ASN A  93
GLY A  33
ARG A  35
ASN A 128
ILE A  30
 None
None
None
PO4  A1503 (-4.1A)
None
 1.18A 3k13B-5a2gA:
3.3		 3k13B-5a2gA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		4 / 7 GLY A 114
SER A 200
PHE A 379
HIS A 416
 None
 0.62A 3o9mA-5a2gA:
43.4		 3o9mA-5a2gA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 GLY A 113
GLY A 114
SER A 200
PHE A 324
HIS A 416
 None
 0.88A 4ey6A-5a2gA:
42.4		 4ey6A-5a2gA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 GLY A 113
GLY A 114
SER A 200
PHE A 324
HIS A 416
 None
 0.88A 4ey6B-5a2gA:
34.4		 4ey6B-5a2gA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 PHE A 386
PHE A 219
ALA A 215
ALA A 310
THR A 307
 None
 1.16A 4fiaA-5a2gA:
undetectable		 4fiaA-5a2gA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 12 PHE A 386
PHE A 219
ALA A 215
ALA A 310
THR A 307
 None
 1.16A 4fiaA-5a2gA:
undetectable		 4fiaA-5a2gA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		3 / 3 HIS A 145
GLY A 202
ILE A 111
 None
 0.43A 4k50A-5a2gA:
undetectable		 4k50A-5a2gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		3 / 3 HIS A 145
GLY A 202
ILE A 111
 None
 0.42A 4k50I-5a2gA:
undetectable		 4k50I-5a2gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		4 / 7 ARG A 380
VAL A 387
VAL A 228
GLY A 318
 None
 0.82A 5x80C-5a2gA:
undetectable
5x80D-5a2gA:
undetectable		 5x80C-5a2gA:
15.82
5x80D-5a2gA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 5a2g CARBOXYLIC ESTER
HYDROLASE
(Hungatella
hathewayi) 		5 / 10 TYR A 152
ASN A 148
HIS A 145
GLY A 113
GLU A 123
 None
 1.27A 6mb7A-5a2gA:
undetectable		 6mb7A-5a2gA:
11.13