SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		5 / 9 GLU H  85
ILE H  69
LEU H  80
GLU H  46
ALA H  60
 None
 1.30A 1ctrA-5a2kH:
undetectable		 1ctrA-5a2kH:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		5 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
 None
 0.88A 3qxtA-5a2kH:
19.9		 3qxtA-5a2kH:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		7 / 12 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
 None
 0.74A 3qxtB-5a2kH:
20.2		 3qxtB-5a2kH:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		6 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
 None
 0.77A 3qxvA-5a2kH:
19.9		 3qxvA-5a2kH:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		6 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
 None
 0.80A 3qxvB-5a2kH:
19.8		 3qxvB-5a2kH:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		6 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
 None
 0.79A 3qxvD-5a2kH:
19.8		 3qxvD-5a2kH:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		5 / 12 ALA H  24
MET H  34
ARG H  71
VAL H  78
TYR H 102
 None
 0.78A 3qxvE-5a2kH:
16.4		 3qxvE-5a2kH:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		4 / 8 GLN H1007
PHE H1098
GLY H1099
GLY H1049
 None
None
None
EDO  H3005 ( 4.7A)
 0.87A 3v3nB-5a2kH:
undetectable		 3v3nB-5a2kH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		4 / 8 GLN H1007
PHE H1098
GLY H1099
GLY H1049
 None
None
None
EDO  H3005 ( 4.7A)
 0.87A 3v3nC-5a2kH:
undetectable		 3v3nC-5a2kH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		4 / 8 ASN H1034
ILE H1048
GLY H  96
VAL H   2
 None
None
EDO  H3005 (-3.4A)
None
 0.71A 4r20A-5a2kH:
undetectable		 4r20A-5a2kH:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		5 / 12 PHE H1062
GLY H1046
ALA H 101
PRO H1059
GLN H1079
 None
 1.23A 4rtpA-5a2kH:
undetectable		 4rtpA-5a2kH:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5a2k IG LAMBDA-1 CHAIN V
REGION S43
(Mus
musculus) 		3 / 3 ALA H1089
TRP H1096
VAL H1097
 None
 0.25A 4w9nC-5a2kH:
undetectable		 4w9nC-5a2kH:
22.90