SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		5 / 9 VAL A 140
VAL A 117
ILE A 127
ALA A 149
LEU A 154
 None
 1.13A 1eqgA-5a2pA:
undetectable		 1eqgA-5a2pA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		5 / 11 VAL A 140
VAL A 117
ILE A 127
ALA A 149
LEU A 154
 None
 1.17A 1eqgB-5a2pA:
undetectable		 1eqgB-5a2pA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		5 / 10 ASP A 158
GLY A 157
GLN A 141
VAL A 140
ARG A 155
 None
 1.50A 1fohA-5a2pA:
undetectable		 1fohA-5a2pA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		5 / 10 ASP A 158
GLY A 157
GLN A 141
VAL A 140
ARG A 155
 None
 1.44A 1fohC-5a2pA:
undetectable		 1fohC-5a2pA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		5 / 10 ASP A 158
GLY A 157
GLN A 141
VAL A 140
ARG A 155
 None
 1.41A 1fohD-5a2pA:
undetectable		 1fohD-5a2pA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		5 / 12 ASN A 247
ARG A 155
ASP A 253
GLY A 218
ILE A 240
 None
 1.22A 1q8jA-5a2pA:
undetectable		 1q8jA-5a2pA:
14.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V1T_A_BEZA1274_0
(SYNTENIN 1)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		4 / 4 HIS A 204
SER A 228
ARG A 231
ASN A 232
 None
 0.43A 1v1tA-5a2pA:
25.8		 1v1tA-5a2pA:
92.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W9E_A_BEZA1274_0
(SYNTENIN 1)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		4 / 4 HIS A 204
SER A 228
ARG A 231
ASN A 232
 None
 0.59A 1w9eA-5a2pA:
25.6		 1w9eA-5a2pA:
92.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W9O_A_BEZA1274_0
(SYNTENIN 1)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		4 / 4 HIS A 204
SER A 228
ARG A 231
ASN A 232
 None
 0.57A 1w9oA-5a2pA:
25.9		 1w9oA-5a2pA:
92.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W9Q_A_BEZA1274_0
(SYNTENIN 1)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		4 / 4 HIS A 204
SER A 228
ARG A 231
ASN A 232
 None
 0.53A 1w9qA-5a2pA:
25.8		 1w9qA-5a2pA:
92.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		4 / 8 ILE A 271
GLY A 233
MET A 203
ILE A 223
 None
 0.81A 2qwxA-5a2pA:
undetectable
2qwxB-5a2pA:
undetectable		 2qwxA-5a2pA:
19.56
2qwxB-5a2pA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		4 / 7 PHE A 213
ASP A 253
ILE A 243
VAL A 267
 None
 1.07A 3p6hA-5a2pA:
undetectable		 3p6hA-5a2pA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5a2p SYNTENIN-1
(Rattus
norvegicus) 		4 / 8 ILE A 271
GLY A 233
MET A 203
ILE A 223
 None
 0.85A 4qogA-5a2pA:
undetectable
4qogB-5a2pA:
undetectable		 4qogA-5a2pA:
19.56
4qogB-5a2pA:
19.56