SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.07A 1dz4A-5a2rA:
undetectable		 1dz4A-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.08A 1dz4B-5a2rA:
undetectable		 1dz4B-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 1dz9A-5a2rA:
undetectable		 1dz9A-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 12 PRO A 482
GLY A 252
GLY A 478
ASP A 474
HIS A 232
 None
 1.23A 1ffyA-5a2rA:
undetectable		 1ffyA-5a2rA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		12 / 12 GLN A 265
HIS A 337
THR A 364
HIS A 367
GLU A 368
HIS A 371
GLU A 395
LYS A 495
HIS A 497
VAL A 502
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
None
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
None
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.30A 1j36A-5a2rA:
58.8		 1j36A-5a2rA:
99.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		12 / 12 GLN A 265
HIS A 337
THR A 364
HIS A 367
GLU A 368
HIS A 371
GLU A 395
LYS A 495
HIS A 497
VAL A 502
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
None
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
None
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.30A 1j36B-5a2rA:
38.7		 1j36B-5a2rA:
99.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		11 / 11 GLN A 265
HIS A 337
HIS A 367
GLU A 368
HIS A 371
GLU A 395
PHE A 441
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 ( 4.8A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.30A 1j37A-5a2rA:
58.0		 1j37A-5a2rA:
99.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 11 HIS A 367
GLU A 368
HIS A 371
GLU A 395
PHE A 511
 ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
None
 1.10A 1j37A-5a2rA:
58.0		 1j37A-5a2rA:
99.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		11 / 11 GLN A 265
HIS A 337
HIS A 367
GLU A 368
HIS A 371
GLU A 395
PHE A 441
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 ( 4.8A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.31A 1j37B-5a2rA:
58.0		 1j37B-5a2rA:
99.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 11 HIS A 367
GLU A 368
HIS A 371
GLU A 395
PHE A 511
 ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
None
 1.10A 1j37B-5a2rA:
58.0		 1j37B-5a2rA:
99.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLY A 388
TYR A 378
GLU A 207
TYR A 344
 None
None
TRS  A7002 (-3.3A)
None
 1.04A 1maaD-5a2rA:
undetectable		 1maaD-5a2rA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 1o76B-5a2rA:
undetectable		 1o76B-5a2rA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		11 / 12 GLN A 265
HIS A 337
HIS A 367
GLU A 368
HIS A 371
GLU A 395
PHE A 441
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 ( 4.8A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.25A 1o86A-5a2rA:
52.5		 1o86A-5a2rA:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		9 / 12 GLU A 150
GLN A 265
HIS A 367
GLU A 395
PHE A 441
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 None
MLT  A1615 (-3.2A)
ZN  A1616 (-3.2A)
ZN  A1616 (-2.4A)
MLT  A1615 ( 4.8A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.83A 1o86A-5a2rA:
52.5		 1o86A-5a2rA:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		6 / 12 HIS A 337
HIS A 367
GLU A 368
HIS A 371
PHE A 511
TYR A 507
 MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
None
MLT  A1615 (-4.0A)
 1.30A 1o86A-5a2rA:
52.5		 1o86A-5a2rA:
44.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 1t85A-5a2rA:
undetectable		 1t85A-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 ILE A 351
ASP A 342
PHE A 343
 None
 0.64A 1uwjB-5a2rA:
undetectable		 1uwjB-5a2rA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.02A 1uyuA-5a2rA:
undetectable		 1uyuA-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.03A 1uyuB-5a2rA:
undetectable		 1uyuB-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.81A 1v7zA-5a2rA:
undetectable		 1v7zA-5a2rA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.82A 1v7zB-5a2rA:
undetectable		 1v7zB-5a2rA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.82A 1v7zC-5a2rA:
undetectable		 1v7zC-5a2rA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.84A 1v7zD-5a2rA:
undetectable		 1v7zD-5a2rA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.84A 1v7zE-5a2rA:
undetectable		 1v7zE-5a2rA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.83A 1v7zF-5a2rA:
undetectable		 1v7zF-5a2rA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 12 ILE A 254
VAL A 248
TYR A 243
ILE A 273
VAL A 235
 None
 1.23A 1z9hD-5a2rA:
1.4		 1z9hD-5a2rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 12 TYR A 378
THR A 387
GLY A 388
GLY A 392
PHE A 375
 None
TRS  A7002 (-3.9A)
None
None
None
 1.28A 2akeA-5a2rA:
undetectable		 2akeA-5a2rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 12 TYR A 378
THR A 387
GLY A 388
GLY A 392
PHE A 375
 None
TRS  A7002 (-3.9A)
None
None
None
 1.29A 2azxA-5a2rA:
undetectable		 2azxA-5a2rA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 11 LEU A 239
ILE A 254
HIS A 232
ARG A 240
GLY A 252
 None
 1.31A 2bxmA-5a2rA:
4.7		 2bxmA-5a2rA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		12 / 12 GLN A 265
HIS A 337
ALA A 338
GLN A 361
HIS A 367
GLU A 368
HIS A 371
GLU A 395
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
MLT  A1615 ( 4.9A)
None
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.56A 2c6nA-5a2rA:
49.9		 2c6nA-5a2rA:
40.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		8 / 12 HIS A 337
ALA A 338
HIS A 371
GLU A 368
GLU A 395
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.8A)
MLT  A1615 ( 4.9A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 1.48A 2c6nA-5a2rA:
49.9		 2c6nA-5a2rA:
40.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		6 / 12 HIS A 337
GLN A 353
HIS A 371
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.8A)
None
ZN  A1616 (-3.3A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 1.30A 2c6nA-5a2rA:
49.9		 2c6nA-5a2rA:
40.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		6 / 12 HIS A 337
GLN A 353
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.8A)
None
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 1.24A 2c6nA-5a2rA:
49.9		 2c6nA-5a2rA:
40.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		10 / 12 GLN A 265
HIS A 337
HIS A 367
GLU A 368
HIS A 371
GLU A 395
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.36A 2c6nB-5a2rA:
50.1		 2c6nB-5a2rA:
40.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 12 HIS A 497
HIS A 371
GLU A 395
GLU A 368
HIS A 337
 MLT  A1615 (-4.0A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-4.3A)
MLT  A1615 (-3.8A)
 1.35A 2c6nB-5a2rA:
50.1		 2c6nB-5a2rA:
40.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.00A 2cppA-5a2rA:
undetectable		 2cppA-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_ACTB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 4 HIS A 394
PRO A 391
ASN A 390
TYR A 374
 None
TRS  A7002 ( 4.9A)
None
None
 1.18A 2f7aB-5a2rA:
undetectable		 2f7aB-5a2rA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 THR A 364
HIS A 367
GLU A 368
HIS A 371
 None
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
 0.25A 2jihB-5a2rA:
undetectable		 2jihB-5a2rA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		11 / 11 GLN A 265
HIS A 337
HIS A 367
GLU A 368
HIS A 371
GLU A 395
PHE A 441
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 ( 4.8A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.16A 2x8zA-5a2rA:
60.8		 2x8zA-5a2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		7 / 11 HIS A 337
HIS A 367
GLU A 368
HIS A 371
GLU A 395
PHE A 511
TYR A 507
 MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
None
MLT  A1615 (-4.0A)
 1.31A 2x8zA-5a2rA:
60.8		 2x8zA-5a2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		12 / 12 GLN A 265
HIS A 337
HIS A 367
GLU A 368
HIS A 371
GLU A 395
LYS A 495
TYR A 496
HIS A 497
VAL A 502
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-2.7A)
None
MLT  A1615 (-4.0A)
None
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.19A 2x91A-5a2rA:
61.0		 2x91A-5a2rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 SER A 339
THR A 364
PHE A 441
 None
None
MLT  A1615 ( 4.8A)
 0.09A 2x91A-5a2rA:
61.0		 2x91A-5a2rA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.12A 2zawA-5a2rA:
undetectable		 2zawA-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 2zaxA-5a2rA:
undetectable		 2zaxA-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 2zwuA-5a2rA:
undetectable		 2zwuA-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.81A 3a6jA-5a2rA:
undetectable		 3a6jA-5a2rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.78A 3a6jB-5a2rA:
undetectable		 3a6jB-5a2rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.79A 3a6jC-5a2rA:
undetectable		 3a6jC-5a2rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.82A 3a6jE-5a2rA:
undetectable		 3a6jE-5a2rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.78A 3a6jF-5a2rA:
undetectable		 3a6jF-5a2rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 5 ILE A 254
HIS A 232
ARG A 240
GLY A 252
 None
 1.18A 3b9mA-5a2rA:
undetectable		 3b9mA-5a2rA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.04A 3fwfA-5a2rA:
undetectable		 3fwfA-5a2rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.04A 3fwfB-5a2rA:
undetectable		 3fwfB-5a2rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 3fwgA-5a2rA:
undetectable		 3fwgA-5a2rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.06A 3fwgB-5a2rA:
undetectable		 3fwgB-5a2rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.03A 3fwjA-5a2rA:
undetectable		 3fwjA-5a2rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 HIS A 367
GLU A 368
HIS A 371
 ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
 0.16A 3kecB-5a2rA:
3.5		 3kecB-5a2rA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.02A 3l63A-5a2rA:
undetectable		 3l63A-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 11 PRO A 382
ASN A  33
LEU A  32
VAL A  76
ALA A  77
 None
 1.37A 3n23C-5a2rA:
undetectable		 3n23C-5a2rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 12 GLY A 174
ALA A 176
SER A 179
ALA A 492
ASP A 171
 None
 1.34A 3nmuA-5a2rA:
2.5
3nmuF-5a2rA:
undetectable		 3nmuA-5a2rA:
22.62
3nmuF-5a2rA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 TYR A 507
ASP A 399
ASP A 437
 MLT  A1615 (-4.0A)
None
None
 0.99A 3ou7B-5a2rA:
undetectable		 3ou7B-5a2rA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 TYR A 165
ASP A 142
ASP A 134
 None
 0.75A 3r24A-5a2rA:
undetectable		 3r24A-5a2rA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 ASN A 429
ALA A 426
LYS A 280
 None
 0.92A 3runA-5a2rA:
undetectable		 3runA-5a2rA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 HIS A 497
SER A 510
GLU A 395
 MLT  A1615 (-4.0A)
None
ZN  A1616 (-2.4A)
 0.80A 3s8pA-5a2rA:
undetectable		 3s8pA-5a2rA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 5 LEU A 556
ALA A 567
PHE A 393
ASN A 572
 None
 1.25A 3uq6A-5a2rA:
undetectable		 3uq6A-5a2rA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 4 LEU A 556
ALA A 567
PHE A 393
ASN A 572
 None
 1.37A 3vaqA-5a2rA:
1.8		 3vaqA-5a2rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 4 LEU A 556
ALA A 567
PHE A 393
ASN A 572
 None
 1.30A 3vasA-5a2rA:
undetectable		 3vasA-5a2rA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.04A 3wrhE-5a2rA:
undetectable		 3wrhE-5a2rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 3wrjE-5a2rA:
undetectable		 3wrjE-5a2rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.00A 3wrlE-5a2rA:
undetectable		 3wrlE-5a2rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 3wrmA-5a2rA:
undetectable		 3wrmA-5a2rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.04A 3wrmF-5a2rA:
undetectable		 3wrmF-5a2rA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 HIS A 371
GLU A 395
ASP A 399
SER A 510
 ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
None
None
 0.30A 4apjA-5a2rA:
49.7
4apjP-5a2rA:
undetectable		 4apjA-5a2rA:
44.76
4apjP-5a2rA:
2.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		11 / 11 GLN A 265
HIS A 337
HIS A 367
GLU A 368
HIS A 371
GLU A 395
PHE A 441
LYS A 495
HIS A 497
TYR A 504
TYR A 507
 MLT  A1615 (-3.2A)
MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 ( 4.8A)
MLT  A1615 (-2.7A)
MLT  A1615 (-4.0A)
MLT  A1615 (-4.7A)
MLT  A1615 (-4.0A)
 0.36A 4c2pA-5a2rA:
52.0		 4c2pA-5a2rA:
44.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 11 GLN A 265
HIS A 367
HIS A 371
GLU A 395
HIS A 337
 MLT  A1615 (-3.2A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-3.8A)
 1.44A 4c2pA-5a2rA:
52.0		 4c2pA-5a2rA:
44.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		6 / 11 HIS A 337
HIS A 367
GLU A 368
HIS A 371
PHE A 511
TYR A 507
 MLT  A1615 (-3.8A)
ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
None
MLT  A1615 (-4.0A)
 1.32A 4c2pA-5a2rA:
52.0		 4c2pA-5a2rA:
44.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 GLU A 425
ILE A 428
ASN A 429
VAL A 602
 None
 0.89A 4ejwB-5a2rA:
undetectable		 4ejwB-5a2rA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.04A 4ek1A-5a2rA:
undetectable		 4ek1A-5a2rA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.09A 4g3rA-5a2rA:
undetectable		 4g3rA-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.09A 4g3rB-5a2rA:
undetectable		 4g3rB-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 11 GLY A 174
VAL A 177
GLN A 180
MET A 123
ILE A 498
 None
 1.38A 4j4vA-5a2rA:
undetectable		 4j4vA-5a2rA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.06A 4kkyX-5a2rA:
undetectable		 4kkyX-5a2rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.05A 4l4bA-5a2rA:
undetectable		 4l4bA-5a2rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.08A 4l4cA-5a2rA:
undetectable		 4l4cA-5a2rA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.03A 4l4dA-5a2rA:
undetectable		 4l4dA-5a2rA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.04A 4l4eA-5a2rA:
undetectable		 4l4eA-5a2rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.03A 4l4fA-5a2rA:
undetectable		 4l4fA-5a2rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 ASP A 437
ASP A 360
SER A 154
ALA A 271
 None
 1.22A 4nedA-5a2rA:
undetectable		 4nedA-5a2rA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 THR A  40
GLU A  43
THR A  44
HIS A 394
 None
 0.99A 4pgfA-5a2rA:
undetectable		 4pgfA-5a2rA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 12 HIS A 367
GLU A 368
HIS A 371
GLU A 395
TYR A 507
 ZN  A1616 (-3.2A)
MLT  A1615 (-4.3A)
ZN  A1616 (-3.3A)
ZN  A1616 (-2.4A)
MLT  A1615 (-4.0A)
 0.65A 4r7lA-5a2rA:
3.7		 4r7lA-5a2rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 5 PHE A 306
SER A 339
HIS A 337
ASP A 399
 None
None
MLT  A1615 (-3.8A)
None
 1.13A 4rzvB-5a2rA:
undetectable		 4rzvB-5a2rA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 11 ASN A 390
ASP A 210
ARG A 575
MET A 577
ILE A 513
 None
 1.45A 4urnC-5a2rA:
undetectable		 4urnC-5a2rA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		5 / 10 PHE A 307
VAL A 405
GLY A 370
GLY A 303
MET A 302
 None
 1.41A 4xpbA-5a2rA:
0.0		 4xpbA-5a2rA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 306
ASP A 541
ILE A 542
TYR A 518
 None
 1.35A 5a06B-5a2rA:
undetectable		 5a06B-5a2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 TYR A 507
SER A 510
GLU A 395
PHE A 441
 MLT  A1615 (-4.0A)
None
ZN  A1616 (-2.4A)
MLT  A1615 ( 4.8A)
 1.02A 5aclA-5a2rA:
undetectable		 5aclA-5a2rA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 TYR A 234
SER A 275
TRP A 592
 None
 0.98A 5n8jB-5a2rA:
undetectable		 5n8jB-5a2rA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 TYR A 234
SER A 275
TRP A 592
 None
 1.00A 5n8jA-5a2rA:
undetectable		 5n8jA-5a2rA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 TYR A 234
SER A 275
TRP A 592
 None
 0.98A 5n8jD-5a2rA:
undetectable		 5n8jD-5a2rA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 6 HIS A 232
LEU A 239
PRO A 255
SER A 249
 None
 1.42A 5syjB-5a2rA:
undetectable		 5syjB-5a2rA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 7 PHE A 490
ARG A 485
ASP A 491
SER A 499
 None
 1.17A 5uxcA-5a2rA:
0.7		 5uxcA-5a2rA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 5 LEU A 505
LYS A 450
LEU A 217
GLU A 218
 None
 1.06A 5weaA-5a2rA:
undetectable		 5weaA-5a2rA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		4 / 8 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.06A 6cp4A-5a2rA:
undetectable		 6cp4A-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 ARG A 473
LYS A 495
TYR A 170
 None
MLT  A1615 (-2.7A)
None
 1.17A 6gnaA-5a2rA:
undetectable		 6gnaA-5a2rA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5a2r ANGIOTENSIN-CONVERTI
NG ENZYME
(Drosophila
melanogaster) 		3 / 3 ARG A 473
LYS A 495
TYR A 170
 None
MLT  A1615 (-2.7A)
None
 1.17A 6gnbA-5a2rA:
undetectable		 6gnbA-5a2rA:
18.99