SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5a2t COAT PROTEIN
(Bamboo
mosaic
virus) 		3 / 3 ALA A 138
VAL A 133
TRP A  68
 None
 0.79A 1micA-5a2tA:
undetectable
1micB-5a2tA:
undetectable		 1micA-5a2tA:
11.43
1micB-5a2tA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 5a2t COAT PROTEIN
(Bamboo
mosaic
virus) 		5 / 12 ASP A 173
PRO A 129
THR A 105
GLY A 100
ALA A 171
 None
U  Z  87 ( 3.8A)
None
U  Z  85 ( 4.8A)
None
 1.21A 1nw5A-5a2tA:
undetectable		 1nw5A-5a2tA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 5a2t COAT PROTEIN
(Bamboo
mosaic
virus) 		5 / 9 ALA A  96
ASP A  98
GLY A  91
LEU A  90
ILE A 130
 None
 1.07A 3em4B-5a2tA:
undetectable		 3em4B-5a2tA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5a2t COAT PROTEIN
(Bamboo
mosaic
virus) 		4 / 6 ASP A 194
TYR A 176
PHE A 142
TYR A 187
 None
 1.45A 5e2iA-5a2tA:
undetectable		 5e2iA-5a2tA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5a2t COAT PROTEIN
(Bamboo
mosaic
virus) 		5 / 12 ASP A 194
ALA A 189
THR A 134
PHE A 142
GLY A 174
 None
 1.28A 5hfjF-5a2tA:
undetectable		 5hfjF-5a2tA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5a2t COAT PROTEIN
(Bamboo
mosaic
virus) 		6 / 11 LEU A 185
PRO A 190
GLY A 174
ARG A 145
THR A 141
ALA A 143
 None
 1.45A 5o96A-5a2tA:
undetectable
5o96B-5a2tA:
undetectable		 5o96A-5a2tA:
20.08
5o96B-5a2tA:
20.08