SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 4 HIS A 162
LEU O 307
LEU O 275
LEU A  37
 None
 1.24A 1a4lD-5a31A:
undetectable		 1a4lD-5a31A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 7 LEU O 590
TYR O 591
HIS O 561
ASN A 776
 None
 1.09A 1afsA-5a31O:
undetectable		 1afsA-5a31O:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 7 LEU O 590
TYR O 591
HIS O 561
ASN A 776
 None
 1.09A 1afsB-5a31O:
undetectable		 1afsB-5a31O:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY A1258
ILE A1232
ALA A1298
GLY A1299
ALA A1297
 None
 0.94A 1bx4A-5a31A:
undetectable		 1bx4A-5a31A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 ASP A1625
ASP A1623
ARG A1702
TYR A1673
 None
 1.43A 1ceaA-5a31A:
undetectable
1ceaB-5a31A:
undetectable		 1ceaA-5a31A:
5.13
1ceaB-5a31A:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ASP A1625
ASP A1623
ARG A1702
TYR A1673
 None
 1.47A 1ceaB-5a31A:
undetectable		 1ceaB-5a31A:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.01A 1ddsA-5a31A:
undetectable		 1ddsA-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.94A 1dyiA-5a31A:
undetectable		 1dyiA-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.04A 1dyiB-5a31A:
undetectable		 1dyiB-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 ALA A1079
GLN A1075
TYR A1552
LEU A1105
 None
 1.17A 1e6wC-5a31A:
undetectable		 1e6wC-5a31A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 LEU A1307
LEU A1612
VAL A1255
GLY A1256
ALA A1301
 None
 1.19A 1e7aA-5a31A:
2.6		 1e7aA-5a31A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 5 ARG R 286
ALA R 272
ASP R 269
GLY R 248
 None
 1.11A 1e7bA-5a31R:
undetectable		 1e7bA-5a31R:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens;
Homo
sapiens) 		5 / 11 SER A1205
LEU A1208
HIS A1231
LEU R 100
LEU A1227
 None
 1.15A 1ee2A-5a31A:
undetectable		 1ee2A-5a31A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens;
Homo
sapiens) 		5 / 11 SER A1205
LEU A1208
HIS A1231
LEU R 100
LEU A1227
 None
 1.16A 1ee2B-5a31A:
undetectable		 1ee2B-5a31A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		6 / 12 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.47A 1eizA-5a31A:
undetectable		 1eizA-5a31A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		6 / 12 ALA A1484
GLY A1478
GLY A1473
LEU A1567
LEU A1564
LEU A1656
 None
 1.45A 1ej0A-5a31A:
undetectable		 1ej0A-5a31A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 LEU O 307
GLU O 326
ALA O 320
LEU O 310
 None
 0.99A 1eta1-5a31O:
undetectable		 1eta1-5a31O:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 LEU O 307
GLU O 326
ALA O 320
LEU O 310
 None
 1.02A 1eta2-5a31O:
undetectable		 1eta2-5a31O:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 6 LEU O 307
GLU O 326
ALA O 320
LEU O 310
 None
 0.96A 1etb1-5a31O:
undetectable		 1etb1-5a31O:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY A1144
LEU A1145
GLY A1174
TYR A1610
LEU A1609
 None
 1.11A 1fduA-5a31A:
undetectable		 1fduA-5a31A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 11 LEU O 473
LEU O 470
ALA O 469
LEU O 445
MET O 444
 None
 1.25A 1g50A-5a31O:
undetectable		 1g50A-5a31O:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 ALA A1561
TRP A1028
ARG A1033
LEU A1562
 None
 1.23A 1gahA-5a31A:
undetectable		 1gahA-5a31A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 THR A 433
VAL A 490
ILE A 587
VAL A 595
ILE A 609
 None
 1.33A 1gebA-5a31A:
undetectable		 1gebA-5a31A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 TYR A 642
THR A 487
LEU A 499
VAL A 509
ILE A 607
 None
 1.32A 1gebA-5a31A:
undetectable		 1gebA-5a31A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		3 / 3 TRP R 359
VAL R 402
TRP R 403
 None
 1.09A 1gmkC-5a31R:
undetectable
1gmkD-5a31R:
undetectable		 1gmkC-5a31R:
4.15
1gmkD-5a31R:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		5 / 9 LEU R 201
ALA R 202
LEU R 232
HIS R 221
LEU R 222
 None
 1.40A 1gwrB-5a31R:
undetectable		 1gwrB-5a31R:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 11 ALA O 630
LEU O 634
LEU O 601
LEU A1787
ALA A1792
 None
 0.97A 1h9zA-5a31O:
2.1		 1h9zA-5a31O:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 11 ALA O 630
LEU O 634
LEU O 601
LEU A1787
ALA A1792
 None
 0.90A 1ha2A-5a31O:
2.9		 1ha2A-5a31O:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		3 / 4 LYS R 316
ALA R 325
MET R 357
 None
 0.77A 1hk3A-5a31R:
undetectable		 1hk3A-5a31R:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 GLU A1480
LEU A1651
ALA A1653
LEU A1634
LEU A1619
 None
 1.46A 1hwiA-5a31A:
undetectable		 1hwiA-5a31A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		4 / 8 ARG N 816
SER N 767
VAL N 814
SER N 811
 None
 1.22A 1hwiB-5a31N:
undetectable		 1hwiB-5a31N:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1374
LEU A1274
GLY A1310
ASN A1312
CYH A1306
 None
 1.07A 1likA-5a31A:
undetectable		 1likA-5a31A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 PHE A1403
ASP A1361
GLU A1292
SER A1295
ALA A1370
 None
 1.45A 1m4dA-5a31A:
undetectable		 1m4dA-5a31A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 PHE A1474
LEU A1585
MET A1304
 None
 0.89A 1mx1D-5a31A:
undetectable		 1mx1D-5a31A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 11 THR O 598
PHE A 949
LEU A1770
PHE A1844
VAL A1774
 None
 1.38A 1q23J-5a31O:
undetectable		 1q23J-5a31O:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 TYR A1172
PHE A1175
ILE A1158
TYR A1196
 None
 1.38A 1qltA-5a31A:
undetectable		 1qltA-5a31A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 TYR A1172
PHE A1175
ILE A1158
TYR A1196
 None
 1.38A 1qltB-5a31A:
undetectable		 1qltB-5a31A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		3 / 3 GLU A1782
TRP A1674
LYS N 320
 None
 1.36A 1qu2A-5a31A:
3.8		 1qu2A-5a31A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 GLU A  91
TRP A 128
LYS O 573
 None
 1.32A 1qu2A-5a31A:
3.8		 1qu2A-5a31A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.90A 1ra8A-5a31A:
undetectable		 1ra8A-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.84A 1rd7A-5a31A:
undetectable		 1rd7A-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.91A 1rd7B-5a31A:
undetectable		 1rd7B-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.00A 1tdrA-5a31A:
undetectable		 1tdrA-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 7 TYR R  91
HIS A1231
LEU A1209
ILE A1193
 None
 0.98A 1tuvA-5a31R:
undetectable		 1tuvA-5a31R:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 TYR A1172
PHE A1175
ILE A1158
TYR A1196
 None
 1.47A 1vaoA-5a31A:
undetectable		 1vaoA-5a31A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 TYR A1172
PHE A1175
ILE A1158
TYR A1196
 None
 1.47A 1vaoB-5a31A:
undetectable		 1vaoB-5a31A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 4 LEU O 402
LEU O 384
SER O 383
LEU O 379
 None
 1.03A 1ya3A-5a31O:
undetectable		 1ya3A-5a31O:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ARG A1607
GLN A1604
PHE A1592
SER A1133
PRO A1128
 None
 1.34A 2a68C-5a31A:
0.0
2a68F-5a31A:
0.2		 2a68C-5a31A:
21.79
2a68F-5a31A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS O 566
ASP A  90
ASP A  86
 None
 0.88A 2br4D-5a31O:
undetectable		 2br4D-5a31O:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.96A 2d0kB-5a31A:
undetectable		 2d0kB-5a31A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 VAL A 123
VAL A 119
LEU A 154
ASP A 120
 None
 0.94A 2ddwA-5a31A:
undetectable		 2ddwA-5a31A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER A1772
THR A1758
GLN O 639
 None
 0.79A 2fk8A-5a31A:
undetectable		 2fk8A-5a31A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 12 PHE O 112
LEU O  38
VAL O  37
VAL O 132
LEU O  60
 None
 1.38A 2hc4A-5a31O:
undetectable		 2hc4A-5a31O:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 5 ASP R 287
SER R 285
GLY R 248
ARG R 293
 None
 0.88A 2j2pA-5a31R:
undetectable
2j2pB-5a31R:
undetectable		 2j2pA-5a31R:
21.41
2j2pB-5a31R:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 6 ARG R 293
ASP R 287
SER R 285
GLY R 248
 None
 1.00A 2j2pA-5a31R:
undetectable
2j2pC-5a31R:
undetectable		 2j2pA-5a31R:
21.41
2j2pC-5a31R:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1814
MET A1840
ALA A 952
PHE A 949
MET A1786
 None
 1.48A 2jj8C-5a31A:
undetectable		 2jj8C-5a31A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 12 LEU O 244
ASN A  36
LEU A  35
ALA A  34
LEU O 236
 None
 1.42A 2oaxD-5a31O:
undetectable		 2oaxD-5a31O:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 GLY O 433
ARG O 434
TYR O 618
 None
 0.77A 2opxA-5a31O:
undetectable		 2opxA-5a31O:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 PRO A  32
ASN O 260
ARG O 263
 None
 0.82A 2qeuB-5a31A:
undetectable		 2qeuB-5a31A:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 6 LEU O 307
GLU O 326
ALA O 320
LEU O 310
 None
 1.08A 2roxB-5a31O:
undetectable		 2roxB-5a31O:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A1473
SER A1483
ALA A1484
CYH A1487
 None
 0.83A 2vh3B-5a31A:
3.1		 2vh3B-5a31A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ILE A 609
ALA A  13
LEU A  17
ILE A 607
ILE A 584
 None
 1.08A 2w9sA-5a31A:
undetectable		 2w9sA-5a31A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ILE A 609
ALA A  13
LEU A  17
ILE A 607
ILE A 584
 None
 1.08A 2w9sB-5a31A:
undetectable		 2w9sB-5a31A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 HIS A 162
TRP A 102
ILE A 164
HIS O 316
 None
 1.02A 2xadA-5a31A:
undetectable		 2xadA-5a31A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 HIS A 162
TRP A 102
ILE A 164
HIS O 316
 None
 1.05A 2xadB-5a31A:
undetectable		 2xadB-5a31A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 HIS A 162
TRP A 102
ILE A 164
HIS O 316
 None
 1.04A 2xadC-5a31A:
undetectable		 2xadC-5a31A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 HIS A 162
TRP A 102
ILE A 164
HIS O 316
 None
 1.01A 2xadD-5a31A:
undetectable		 2xadD-5a31A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 ALA A1605
LEU A1612
LEU A1259
LEU A1210
LEU A1609
 None
 1.17A 2xn6A-5a31A:
undetectable
2xn6B-5a31A:
undetectable		 2xn6A-5a31A:
13.19
2xn6B-5a31A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 LEU A1302
MET A1304
VAL A1254
ILE A1374
ALA A1370
 None
 1.13A 2yy8A-5a31A:
undetectable
2yy8B-5a31A:
undetectable		 2yy8A-5a31A:
9.30
2yy8B-5a31A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		5 / 11 LEU R 232
VAL R 243
GLY R 244
VAL R 271
ALA R 204
 None
 1.05A 2yy8A-5a31R:
undetectable
2yy8B-5a31R:
undetectable		 2yy8A-5a31R:
18.39
2yy8B-5a31R:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 ASP O 165
PHE O 162
LEU O 158
 None
 0.36A 2zi9A-5a31O:
undetectable		 2zi9A-5a31O:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ALA A1298
ALA A1297
ALA A1301
GLN A1250
 None
 0.80A 3a2qA-5a31A:
undetectable		 3a2qA-5a31A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 LEU A1585
ALA A1410
ALA A1372
MET A1373
LEU A1307
 None
 1.17A 3bszE-5a31A:
undetectable		 3bszE-5a31A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 5 LEU R  99
THR A1190
HIS A1231
LEU A1209
 None
 1.19A 3ce6D-5a31R:
undetectable		 3ce6D-5a31R:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		4 / 5 LEU N 428
GLN N 437
THR N 434
LEU N 386
 None
 1.21A 3ce6D-5a31N:
undetectable		 3ce6D-5a31N:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ILE A  12
ILE A 511
PRO A 512
LEU A 597
THR A 487
 None
 0.96A 3clbA-5a31A:
undetectable		 3clbA-5a31A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1609
GLY A1256
GLN A1262
ALA A1252
LEU A1273
 None
 1.12A 3dh0B-5a31A:
undetectable		 3dh0B-5a31A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 8 PRO R 343
HIS R 288
VAL R 312
GLY R 328
 None
 0.82A 3em0B-5a31R:
undetectable		 3em0B-5a31R:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 MET A1550
ALA A1557
LEU A1520
LEU A1521
LEU A1542
 None
 1.49A 3erdB-5a31A:
undetectable		 3erdB-5a31A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 ASN A1532
MET A1024
PHE A1566
 None
 0.71A 3g4lD-5a31A:
undetectable		 3g4lD-5a31A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA A1477
LEU A1406
LEU A1409
HIS A1602
LEU A1588
 None
 0.91A 3gcsA-5a31A:
undetectable		 3gcsA-5a31A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 VAL O 713
GLN O 717
ILE O 648
GLY O 661
 None
 0.77A 3hjoA-5a31O:
3.1		 3hjoA-5a31O:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 ARG A 871
THR A 946
THR A 620
 None
 0.78A 3k2hB-5a31A:
undetectable		 3k2hB-5a31A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ALA A1252
ILE A1206
GLY A1207
LEU A1603
ALA A1605
 None
 1.16A 3kw2A-5a31A:
undetectable		 3kw2A-5a31A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ALA A1252
ILE A1206
GLY A1207
LEU A1603
ALA A1605
 None
 1.20A 3kw2B-5a31A:
undetectable		 3kw2B-5a31A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 LEU A1413
LEU A1585
SER A1579
ASN A1578
 None
 0.97A 3lm8B-5a31A:
undetectable
3lm8D-5a31A:
undetectable		 3lm8B-5a31A:
9.85
3lm8D-5a31A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 ARG O 280
HIS O 276
ALA O 251
HIS O 254
 None
 1.27A 3mbgB-5a31O:
2.2
3mbgC-5a31O:
2.2		 3mbgB-5a31O:
10.33
3mbgC-5a31O:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 HIS O 254
ARG O 280
HIS O 276
ALA O 251
 None
 1.27A 3mbgB-5a31O:
2.2
3mbgC-5a31O:
2.2		 3mbgB-5a31O:
10.33
3mbgC-5a31O:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 SER A1423
VAL A1426
TRP A1425
PHE A1476
 None
 1.36A 3n5tA-5a31A:
undetectable
3n5tB-5a31A:
undetectable		 3n5tA-5a31A:
15.42
3n5tB-5a31A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.28A 3n61A-5a31A:
undetectable
3n61B-5a31A:
undetectable		 3n61A-5a31A:
14.10
3n61B-5a31A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 PHE A 431
ASP A 478
ILE A 587
SER A 586
LEU A 445
 None
 1.24A 3o1cA-5a31A:
undetectable		 3o1cA-5a31A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ALA A 112
VAL A 113
GLN O 265
 None
 0.62A 3of4B-5a31A:
undetectable		 3of4B-5a31A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		3 / 3 GLN N 437
THR N 434
LEU N 386
 None
 0.68A 3ondA-5a31N:
undetectable		 3ondA-5a31N:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens) 		3 / 3 GLN N 437
THR N 434
LEU N 386
 None
 0.68A 3ondB-5a31N:
undetectable		 3ondB-5a31N:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA A1297
GLY A1299
MET A1304
ALA A1252
HIS A1602
 None
 1.33A 3ou7C-5a31A:
undetectable		 3ou7C-5a31A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.74A 3p50A-5a31A:
5.2		 3p50A-5a31A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.75A 3p50B-5a31A:
5.2		 3p50B-5a31A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.74A 3p50C-5a31A:
5.3		 3p50C-5a31A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.75A 3p50D-5a31A:
5.2		 3p50D-5a31A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.76A 3p50E-5a31A:
5.2		 3p50E-5a31A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 TYR O 700
PHE O 665
ARG O 709
LEU O 658
 None
 1.45A 3qelC-5a31O:
undetectable		 3qelC-5a31O:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.48A 3qpkA-5a31A:
undetectable		 3qpkA-5a31A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.49A 3qpkB-5a31A:
undetectable		 3qpkB-5a31A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 HIS A  31
HIS A  27
ILE A 101
 None
 0.70A 3u52A-5a31A:
undetectable
3u52C-5a31A:
undetectable		 3u52A-5a31A:
15.00
3u52C-5a31A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 LEU A1585
TYR A1326
MET A1329
ARG A1475
 None
 1.47A 4bkjB-5a31A:
undetectable		 4bkjB-5a31A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 LYS A1700
LEU A1747
TYR A1708
ARG A 956
 None
 1.29A 4bkjB-5a31A:
undetectable		 4bkjB-5a31A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 SER A1428
LEU A1405
GLY A1467
SER A1471
LEU A1472
 None
 1.17A 4coxB-5a31A:
undetectable		 4coxB-5a31A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 SER A1428
LEU A1405
GLY A1467
SER A1471
LEU A1472
 None
 1.15A 4coxD-5a31A:
undetectable		 4coxD-5a31A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A1488
GLY A1531
ALA A1528
VAL A1535
GLY A1563
 None
 0.93A 4dc3A-5a31A:
undetectable		 4dc3A-5a31A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.03A 4dfrA-5a31A:
undetectable		 4dfrA-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ALA A1389
ALA A1468
GLY A1467
ILE A1465
 None
 0.57A 4eatA-5a31A:
undetectable		 4eatA-5a31A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.97A 4ej1A-5a31A:
undetectable		 4ej1A-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ASN O 261
ASP O 266
LEU A  35
HIS A  31
 None
 1.14A 4f5zA-5a31O:
undetectable		 4f5zA-5a31O:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.00A 4fhbA-5a31A:
undetectable		 4fhbA-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 SER A1295
ILE A1277
LEU A1319
GLY A1303
TYR A1375
 None
 1.26A 4fogA-5a31A:
undetectable		 4fogA-5a31A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 SER A1295
ILE A1277
LEU A1319
GLY A1303
TYR A1375
 None
 1.27A 4fogC-5a31A:
undetectable		 4fogC-5a31A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.34A 4k5jA-5a31A:
undetectable
4k5jB-5a31A:
undetectable		 4k5jA-5a31A:
15.28
4k5jB-5a31A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 VAL A1526
ALA A1528
LEU A1588
SER A1580
ILE A1581
 None
 1.10A 4ky8B-5a31A:
undetectable		 4ky8B-5a31A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 5 GLY R 284
SER R 285
ALA R 272
GLU R 311
 None
 0.99A 4m93B-5a31R:
undetectable
4m93C-5a31R:
undetectable		 4m93B-5a31R:
21.35
4m93C-5a31R:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 PHE A1137
HIS A1138
TYR A1552
ASN A1248
 None
 1.49A 4o7gB-5a31A:
undetectable		 4o7gB-5a31A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.97A 4p3rA-5a31A:
undetectable		 4p3rA-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.95A 4pssA-5a31A:
undetectable		 4pssA-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 12 LEU O 473
LEU O 470
ALA O 469
LEU O 445
MET O 444
 None
 1.12A 4pxmA-5a31O:
undetectable		 4pxmA-5a31O:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.91A 4qleA-5a31A:
undetectable		 4qleA-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.97A 4qlgB-5a31A:
undetectable		 4qlgB-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 ILE A 485
VAL A 482
PHE A  20
HIS A 645
 None
 1.33A 4rzvA-5a31A:
undetectable		 4rzvA-5a31A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 8 LEU R 264
ILE R 252
LEU R 274
SER R 231
 None
 0.57A 4wboB-5a31R:
undetectable		 4wboB-5a31R:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.92A 4x5fA-5a31A:
undetectable		 4x5fA-5a31A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.93A 4x5fB-5a31A:
undetectable		 4x5fB-5a31A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.90A 4x5gA-5a31A:
undetectable		 4x5gA-5a31A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.94A 4x5gB-5a31A:
undetectable		 4x5gB-5a31A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.98A 4x5hA-5a31A:
undetectable		 4x5hA-5a31A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 LEU A1100
GLU A1171
LEU A1145
HIS A1184
 None
 1.34A 4xi3B-5a31A:
undetectable		 4xi3B-5a31A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.31A 5adlA-5a31A:
undetectable
5adlB-5a31A:
undetectable		 5adlA-5a31A:
15.28
5adlB-5a31A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 6 ARG O 298
GLY O 297
SER O 299
LEU O 283
 None
 1.25A 5bphA-5a31O:
undetectable		 5bphA-5a31O:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 6 ARG O 298
GLY O 297
SER O 299
LEU O 283
 None
 1.26A 5bphD-5a31O:
undetectable		 5bphD-5a31O:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 ILE A1414
GLY A1308
ILE A1383
LEU A1376
 None
 0.81A 5dzkB-5a31A:
undetectable
5dzkI-5a31A:
undetectable
5dzkW-5a31A:
undetectable		 5dzkB-5a31A:
9.87
5dzkI-5a31A:
8.84
5dzkW-5a31A:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 ILE A1414
GLY A1308
ILE A1383
LEU A1376
 None
 0.86A 5dzki-5a31A:
undetectable
5dzkj-5a31A:
undetectable
5dzkx-5a31A:
undetectable		 5dzki-5a31A:
8.84
5dzkj-5a31A:
8.84
5dzkx-5a31A:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 ILE A1414
GLY A1308
ILE A1383
LEU A1376
 None
 0.92A 5dzkd-5a31A:
undetectable
5dzkk-5a31A:
undetectable
5dzky-5a31A:
undetectable		 5dzkd-5a31A:
9.87
5dzkk-5a31A:
8.84
5dzky-5a31A:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.02A 5e8qB-5a31A:
undetectable		 5e8qB-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.02A 5eajB-5a31A:
undetectable		 5eajB-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 10 ALA A1275
ALA A1234
LEU A1302
VAL A1254
TYR A1294
 None
 1.26A 5eb5B-5a31A:
undetectable		 5eb5B-5a31A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 8 LEU A1405
GLY A1467
ALA A1468
SER A1471
 None
 0.79A 5f1aA-5a31A:
undetectable		 5f1aA-5a31A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 LEU A1405
GLY A1467
ALA A1468
SER A1471
 None
 0.77A 5f1aB-5a31A:
undetectable		 5f1aB-5a31A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL O 267
ILE A 153
LEU A 187
CYH A 129
ALA A 171
 None
 1.44A 5fctB-5a31O:
undetectable		 5fctB-5a31O:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.29A 5fj3A-5a31A:
undetectable
5fj3B-5a31A:
3.2		 5fj3A-5a31A:
15.28
5fj3B-5a31A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 6 LEU R 205
LEU R 232
LEU R 201
HIS R 444
 None
 1.00A 5gs4A-5a31R:
undetectable		 5gs4A-5a31R:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		4 / 5 LEU R 205
LEU R 232
LEU R 201
HIS R 444
 None
 0.98A 5gtrA-5a31R:
undetectable		 5gtrA-5a31R:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		5 / 11 LEU R 201
ALA R 202
LEU R 232
HIS R 221
LEU R 222
 None
 1.43A 5hyrB-5a31R:
undetectable		 5hyrB-5a31R:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 9 ARG A1279
ALA A1297
VAL A1251
GLU A1276
ILE A1206
 None
 1.39A 5i3cA-5a31A:
undetectable		 5i3cA-5a31A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 VAL A1047
GLN A1072
CYH A1074
 None
 0.80A 5icxA-5a31A:
undetectable
5icxE-5a31A:
undetectable		 5icxA-5a31A:
9.48
5icxE-5a31A:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 VAL A1047
GLN A1072
CYH A1074
 None
 0.89A 5icxC-5a31A:
undetectable
5icxF-5a31A:
undetectable		 5icxC-5a31A:
9.48
5icxF-5a31A:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 MET A1177
TYR A1294
GLU A1276
ALA A1297
LEU A1603
 None
 1.03A 5ienB-5a31A:
2.5		 5ienB-5a31A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PRO R 152
ALA A1270
VAL A1272
LEU A1319
GLY A1315
 None
 1.03A 5igtA-5a31R:
2.7		 5igtA-5a31R:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 7 LEU O 567
TYR O 545
ASP O 517
LEU O 563
 None
 1.02A 5jq7B-5a31O:
undetectable		 5jq7B-5a31O:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 LYS O 397
ASP O 400
ARG O 388
 None
 1.05A 5jwaA-5a31O:
undetectable
5jwaH-5a31O:
undetectable		 5jwaA-5a31O:
21.98
5jwaH-5a31O:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 PHE O 215
SER O 217
ASN O 247
ASP O 249
 None
 1.42A 5kpcA-5a31O:
undetectable		 5kpcA-5a31O:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 ASN A1627
TYR A1698
CYH A1630
 None
 1.03A 5lsuB-5a31A:
undetectable		 5lsuB-5a31A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA504_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mejA-5a31A:
undetectable		 5mejA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA504_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mewA-5a31A:
undetectable		 5mewA-5a31A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA504_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mhuA-5a31A:
undetectable		 5mhuA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA504_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mhvA-5a31A:
undetectable		 5mhvA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mhwA-5a31A:
undetectable		 5mhwA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5mhxA-5a31A:
undetectable		 5mhxA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5mhyA-5a31A:
undetectable		 5mhyA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5mhzA-5a31A:
undetectable		 5mhzA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5mi1A-5a31A:
undetectable		 5mi1A-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5mi2A-5a31A:
undetectable		 5mi2A-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5miaA-5a31A:
undetectable		 5miaA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5mibA-5a31A:
undetectable		 5mibA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5micA-5a31A:
undetectable		 5micA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5midA-5a31A:
undetectable		 5midA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5mieA-5a31A:
undetectable		 5mieA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA604_0
(LACCASE 2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5migA-5a31A:
undetectable		 5migA-5a31A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 LYS O  34
LYS O  27
SER O 208
 None
 1.49A 5odiA-5a31O:
undetectable		 5odiA-5a31O:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 TYR A1601
PRO A1401
LEU A1404
PHE A1403
 None
 1.11A 5tl8A-5a31A:
0.3		 5tl8A-5a31A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 LEU A1609
LEU A1612
MET A1373
TYR A1589
 None
 1.17A 5uc3A-5a31A:
undetectable		 5uc3A-5a31A:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 1.01A 5ujxB-5a31A:
undetectable		 5ujxB-5a31A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 ARG A 588
ASP A 589
LEU A  76
SER A 103
 None
 1.00A 5uxcA-5a31A:
2.2		 5uxcA-5a31A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 4 GLU O 622
THR O 623
THR O 577
LEU O 431
 None
 1.35A 5v96C-5a31O:
undetectable		 5v96C-5a31O:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 LYS O 660
ALA O 663
LEU O 666
LEU O 652
 None
 0.80A 5vkqA-5a31O:
5.0
5vkqD-5a31O:
4.2		 5vkqA-5a31O:
18.91
5vkqD-5a31O:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 LEU O 652
LYS O 660
ALA O 663
LEU O 666
 None
 0.81A 5vkqA-5a31O:
5.0
5vkqB-5a31O:
5.0		 5vkqA-5a31O:
18.91
5vkqB-5a31O:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 LEU O 652
LYS O 660
ALA O 663
LEU O 666
 None
 0.78A 5vkqB-5a31O:
5.0
5vkqC-5a31O:
5.0		 5vkqB-5a31O:
18.91
5vkqC-5a31O:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 5 LEU O 652
LYS O 660
ALA O 663
LEU O 666
 None
 0.82A 5vkqC-5a31O:
5.0
5vkqD-5a31O:
4.2		 5vkqC-5a31O:
18.91
5vkqD-5a31O:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 GLY O 661
GLU O 696
ILE O 648
GLN O 617
 None
 0.88A 5vlmD-5a31O:
2.2		 5vlmD-5a31O:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLN O 639
ALA O 640
LEU A1768
ILE A1767
ARG A1798
 None
 1.25A 5vlmG-5a31O:
undetectable		 5vlmG-5a31O:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.32A 5vv7A-5a31A:
undetectable
5vv7B-5a31A:
3.3		 5vv7A-5a31A:
15.28
5vv7B-5a31A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.28A 5vvnA-5a31A:
undetectable
5vvnB-5a31A:
undetectable		 5vvnA-5a31A:
15.28
5vvnB-5a31A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
MET A1525
LEU A1470
THR A1576
ILE A1581
 None
 1.32A 5z6fA-5a31A:
undetectable		 5z6fA-5a31A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.92A 5z6jA-5a31A:
undetectable		 5z6jA-5a31A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1419
LEU A1409
THR A1576
ILE A1581
LEU A1376
 None
 0.92A 5z6kA-5a31A:
undetectable		 5z6kA-5a31A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		6 / 12 ILE A1257
GLY A1303
ALA A1301
TYR A1261
ALA A1372
ALA A1367
 None
 1.35A 5zw4A-5a31A:
undetectable		 5zw4A-5a31A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 SER A1423
VAL A1426
TRP A1425
PHE A1476
 None
 1.31A 6av6A-5a31A:
undetectable
6av6B-5a31A:
undetectable		 6av6A-5a31A:
4.67
6av6B-5a31A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 PHE A1476
SER A1423
VAL A1426
TRP A1425
 None
 1.28A 6av6C-5a31A:
undetectable
6av6D-5a31A:
undetectable		 6av6C-5a31A:
4.67
6av6D-5a31A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 7 SER A1423
VAL A1426
TRP A1425
PHE A1476
 None
 1.32A 6av7A-5a31A:
0.0
6av7B-5a31A:
undetectable		 6av7A-5a31A:
4.67
6av7B-5a31A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		4 / 8 HIS A 645
ARG A  15
HIS O 526
GLU A 611
 None
 1.14A 6b94A-5a31A:
undetectable		 6b94A-5a31A:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens) 		5 / 9 LEU O 446
ARG O 430
ALA O 469
VAL O 468
SER O 465
 None
 1.10A 6c2mB-5a31O:
undetectable		 6c2mB-5a31O:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 4 VAL A1462
ALA A1466
PHE A1495
PHE A1491
 None
 1.44A 6cbdA-5a31A:
undetectable		 6cbdA-5a31A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens) 		5 / 10 LEU R 201
ALA R 202
LEU R 232
HIS R 221
LEU R 222
 None
 1.41A 6cbzB-5a31R:
undetectable		 6cbzB-5a31R:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL A1848
CYH A1850
THR A1851
PHE N 163
THR N 155
 None
 1.41A 6cm4A-5a31A:
undetectable		 6cm4A-5a31A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 ASP A1154
ASN A1192
LEU A1176
PHE A1175
 None
 1.08A 6ekuA-5a31A:
8.4		 6ekuA-5a31A:
19.94