SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Streptococcus
pyogenes) 		3 / 3 THR A  77
PRO A  80
THR A  79
 None
 0.94A 1dscC-5a35A:
undetectable		 1dscC-5a35A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Streptococcus
pyogenes) 		4 / 4 LEU A  50
LEU A  62
SER A  63
LEU A  43
 None
 1.15A 1ya3A-5a35A:
undetectable		 1ya3A-5a35A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Streptococcus
pyogenes) 		3 / 3 LYS A   2
LEU A   9
ALA A 110
 None
 0.65A 4iizA-5a35A:
undetectable		 4iizA-5a35A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Streptococcus
pyogenes) 		4 / 6 ASN A   6
ILE A  93
ILE A  19
VAL A  94
 None
 0.83A 4olmA-5a35A:
undetectable		 4olmA-5a35A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Streptococcus
pyogenes) 		5 / 9 SER A  63
ILE A  49
ASP A  41
ALA A  68
THR A  97
 None
 1.09A 4r1zA-5a35A:
undetectable		 4r1zA-5a35A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Streptococcus
pyogenes) 		5 / 9 ILE A  19
THR A  38
LEU A  43
ASN A   6
LEU A  62
 None
 1.14A 5fhzB-5a35A:
undetectable		 5fhzB-5a35A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Streptococcus
pyogenes) 		5 / 10 ILE A  19
THR A  38
LEU A  43
ASN A   6
LEU A  62
 None
 1.18A 5fhzC-5a35A:
undetectable		 5fhzC-5a35A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Streptococcus
pyogenes) 		3 / 3 SER A  63
LEU A  83
MET A  21
 None
 0.76A 5ikrB-5a35A:
undetectable		 5ikrB-5a35A:
11.52