SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		4 / 6 ALA A  34
SER A  37
ASN A 118
ASP A 120
 NAD  A1294 (-3.3A)
NAD  A1294 ( 4.1A)
NAD  A1294 (-3.9A)
NAD  A1294 (-3.9A)
 0.27A 1yc2A-5a3cA:
13.7		 1yc2A-5a3cA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		4 / 7 ALA A  34
SER A  37
ASN A 118
ASP A 120
 NAD  A1294 (-3.3A)
NAD  A1294 ( 4.1A)
NAD  A1294 (-3.9A)
NAD  A1294 (-3.9A)
 0.31A 1yc5A-5a3cA:
13.1		 1yc5A-5a3cA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		3 / 3 CYH A 180
CYH A 149
HIS A 150
 ZN  A1293 (-2.0A)
ZN  A1293 (-2.3A)
None
 0.78A 2iwkA-5a3cA:
undetectable		 2iwkA-5a3cA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		3 / 3 CYH A 180
CYH A 149
HIS A 150
 ZN  A1293 (-2.0A)
ZN  A1293 (-2.3A)
None
 0.74A 2iwkB-5a3cA:
undetectable		 2iwkB-5a3cA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		3 / 3 CYH A 180
CYH A 149
HIS A 150
 ZN  A1293 (-2.0A)
ZN  A1293 (-2.3A)
None
 0.78A 3dtuB-5a3cA:
undetectable		 3dtuB-5a3cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		3 / 3 CYH A 180
CYH A 149
HIS A 150
 ZN  A1293 (-2.0A)
ZN  A1293 (-2.3A)
None
 0.77A 3dtuD-5a3cA:
undetectable		 3dtuD-5a3cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		3 / 3 SER A  84
GLN A  83
PHE A  86
 None
EDO  A1295 ( 4.9A)
None
 0.85A 3g4lC-5a3cA:
undetectable		 3g4lC-5a3cA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		4 / 7 VAL A 172
ILE A 160
ILE A 164
GLN A 167
 None
 0.91A 3hgxA-5a3cA:
undetectable		 3hgxA-5a3cA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		3 / 3 GLN A  17
THR A   6
THR A   5
 None
 0.60A 4fu9A-5a3cA:
undetectable		 4fu9A-5a3cA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		3 / 3 GLN A  17
THR A   6
THR A   5
 None
 0.59A 4fufA-5a3cA:
undetectable		 4fufA-5a3cA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		4 / 7 ASP A 120
ASN A 118
ILE A 133
TRP A 124
 NAD  A1294 (-3.9A)
NAD  A1294 (-3.9A)
None
None
 1.26A 4ii8A-5a3cA:
undetectable		 4ii8A-5a3cA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		5 / 12 LEU A 142
GLY A 138
MET A 198
VAL A 199
HIS A 205
 None
 1.32A 4olmA-5a3cA:
undetectable		 4olmA-5a3cA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		4 / 8 THR A 116
GLY A  35
GLY A 229
VAL A 230
 None
NAD  A1294 (-3.3A)
NAD  A1294 (-3.4A)
NAD  A1294 (-3.8A)
 0.70A 4qvvK-5a3cA:
undetectable
4qvvL-5a3cA:
undetectable		 4qvvK-5a3cA:
18.90
4qvvL-5a3cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		4 / 8 THR A 116
GLY A  35
GLY A 229
VAL A 230
 None
NAD  A1294 (-3.3A)
NAD  A1294 (-3.4A)
NAD  A1294 (-3.8A)
 0.70A 4qvvY-5a3cA:
undetectable
4qvvZ-5a3cA:
undetectable		 4qvvY-5a3cA:
18.90
4qvvZ-5a3cA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		4 / 7 PHE A 214
ALA A  27
ILE A  22
LEU A 107
 GLY  A1299 (-4.7A)
None
None
None
 1.07A 4uymA-5a3cA:
undetectable		 4uymA-5a3cA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		5 / 12 GLY A  41
TYR A  44
GLU A 139
ILE A  32
TYR A 100
 None
NAD  A1294 (-3.5A)
None
None
None
 1.32A 5igwA-5a3cA:
undetectable		 5igwA-5a3cA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 5a3c SIR2 FAMILY PROTEIN
(Streptococcus
pyogenes) 		4 / 8 ILE A 136
ASP A 201
ASP A 203
HIS A 205
 None
 0.93A 6ag0A-5a3cA:
undetectable		 6ag0A-5a3cA:
13.53