SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 9 LEU A 561
LEU A 541
GLU A 544
VAL A 568
PHE A 582
 None
 1.29A 1gx8A-5a3fA:
undetectable		 1gx8A-5a3fA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5a3f DYNAMIN 3
(Homo
sapiens) 		3 / 4 LYS A 325
ALA A 328
MET A 705
 None
 1.06A 1hk3A-5a3fA:
undetectable		 1hk3A-5a3fA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5a3f DYNAMIN 3
(Homo
sapiens) 		4 / 7 PHE A 372
VAL A 568
VAL A 609
ASP A 610
 None
 0.98A 1p7rA-5a3fA:
undetectable		 1p7rA-5a3fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		3 / 3 ASP A 241
GLU A  79
ARG A  98
 None
 0.80A 1wopA-5a3fA:
undetectable		 1wopA-5a3fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5a3f DYNAMIN 3
(Homo
sapiens) 		3 / 3 LEU A 617
PHE A 372
ARG A 569
 None
 0.63A 1xdkF-5a3fA:
undetectable		 1xdkF-5a3fA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		4 / 8 LYS A 376
LYS A 472
ARG A 369
GLU A 468
 None
 1.47A 1xr2B-5a3fA:
undetectable		 1xr2B-5a3fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5a3f DYNAMIN 3
(Homo
sapiens) 		4 / 4 GLN A 155
GLU A 153
ILE A 152
PRO A 149
 None
 1.48A 2fcnA-5a3fA:
undetectable		 2fcnA-5a3fA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 12 LEU A  29
ALA A 724
GLY A 730
ILE A 731
LEU A  31
 None
 0.97A 2o4nA-5a3fA:
undetectable		 2o4nA-5a3fA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 5a3f DYNAMIN 3
(Homo
sapiens) 		4 / 4 GLU A  82
ARG A 123
ASN A 121
ASP A  18
 None
 1.16A 2zq9A-5a3fA:
undetectable		 2zq9A-5a3fA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5a3f DYNAMIN 3
(Homo
sapiens) 		3 / 3 TRP A 612
VAL A 592
ARG A 590
 None
 0.83A 3b0wA-5a3fA:
undetectable		 3b0wA-5a3fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 11 ALA A 186
ALA A 173
VAL A 232
LEU A 281
GLN A 284
 None
 1.31A 3bszE-5a3fA:
undetectable		 3bszE-5a3fA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 11 LEU A  69
LEU A  71
LEU A  57
GLY A 139
LEU A 137
 None
 1.33A 3hm1B-5a3fA:
undetectable		 3hm1B-5a3fA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		3 / 3 SER A 661
ASP A 657
ASP A 492
 None
 0.38A 3iv6A-5a3fA:
undetectable		 3iv6A-5a3fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		3 / 3 SER A 661
ASP A 657
ASP A 492
 None
 0.37A 3iv6C-5a3fA:
undetectable		 3iv6C-5a3fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		4 / 6 ILE A 581
PHE A 598
ALA A 583
ASN A 526
 None
 1.09A 3pgyA-5a3fA:
undetectable
3pgyB-5a3fA:
undetectable		 3pgyA-5a3fA:
20.73
3pgyB-5a3fA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 9 VAL A 124
GLY A  53
ILE A 248
PRO A 127
THR A  75
 None
 1.35A 3spkA-5a3fA:
undetectable		 3spkA-5a3fA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 12 GLN A  40
GLY A  38
GLY A 139
SER A 184
ALA A  42
 None
 1.38A 3t7sC-5a3fA:
undetectable		 3t7sC-5a3fA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5a3f DYNAMIN 3
(Homo
sapiens) 		4 / 5 HIS A 288
LEU A  16
LEU A  29
ASP A  18
 None
 1.16A 4aqlA-5a3fA:
undetectable		 4aqlA-5a3fA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 12 PRO A 623
ALA A 614
ILE A 581
LEU A 584
LEU A 599
 None
 0.95A 4l9qB-5a3fA:
1.5		 4l9qB-5a3fA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5a3f DYNAMIN 3
(Homo
sapiens) 		3 / 3 MET A 676
ASP A 685
PHE A 686
 None
 1.04A 4xeyB-5a3fA:
undetectable		 4xeyB-5a3fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5a3f DYNAMIN 3
(Homo
sapiens) 		3 / 3 PRO A  68
LEU A  29
SER A 117
 None
 0.77A 5fsaB-5a3fA:
0.1		 5fsaB-5a3fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 12 VAL A 592
LEU A 546
LEU A 522
THR A 523
ARG A 597
 None
 1.30A 5hnxB-5a3fA:
undetectable		 5hnxB-5a3fA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 5a3f DYNAMIN 3
(Homo
sapiens) 		4 / 7 VAL A 124
ALA A  81
LEU A  71
LEU A  69
 None
 0.57A 5jq7A-5a3fA:
undetectable		 5jq7A-5a3fA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a3f DYNAMIN 3
(Homo
sapiens) 		4 / 4 LEU A 435
ARG A 343
ILE A 344
PHE A 340
 None
 1.34A 5kirB-5a3fA:
undetectable		 5kirB-5a3fA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5a3f DYNAMIN 3
(Homo
sapiens) 		5 / 10 ILE A 675
ILE A 680
MET A 679
ILE A 432
ILE A 464
 None
 0.90A 5murE-5a3fA:
3.2		 5murE-5a3fA:
8.43