SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		3 / 3 ARG A 220
THR A 249
VAL A 244
 None
 1.00A 2qakA-5a3kA:
undetectable		 2qakA-5a3kA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		4 / 7 GLY A 153
THR A 107
PHE A 158
PHE A 168
 None
 1.20A 2qx4A-5a3kA:
undetectable
2qx4B-5a3kA:
undetectable		 2qx4A-5a3kA:
20.46
2qx4B-5a3kA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		5 / 12 MET A  56
GLU A 334
VAL A 146
ILE A 133
ASN A 131
 None
None
None
None
3HB  A1341 (-4.3A)
 1.20A 3jayA-5a3kA:
undetectable		 3jayA-5a3kA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		5 / 9 TYR A 184
LEU A 322
VAL A  34
PHE A  64
VAL A 320
 None
 1.46A 3jwqA-5a3kA:
undetectable		 3jwqA-5a3kA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		5 / 10 TYR A 111
LEU A 118
VAL A 126
PRO A 169
ALA A 171
 None
None
None
None
3HB  A1341 (-3.5A)
 1.40A 3nuvB-5a3kA:
undetectable		 3nuvB-5a3kA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		3 / 3 ARG A 290
TYR A  36
ASN A  17
 None
 0.96A 4ffwB-5a3kA:
undetectable		 4ffwB-5a3kA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		3 / 3 TYR A 147
ARG A 328
SER A 327
 3HB  A1341 (-3.9A)
None
3HB  A1341 (-3.0A)
 1.01A 4khpI-5a3kA:
undetectable
4khpJ-5a3kA:
undetectable		 4khpI-5a3kA:
18.73
4khpJ-5a3kA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		5 / 10 ALA A 312
ILE A 292
VAL A 294
ALA A 262
ILE A 335
 None
 0.95A 4lbgA-5a3kA:
undetectable		 4lbgA-5a3kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		5 / 9 ALA A 312
ILE A 292
VAL A 294
ALA A 262
ILE A 335
 None
 0.90A 4lbgB-5a3kA:
undetectable		 4lbgB-5a3kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		4 / 5 GLY A 240
THR A 241
GLY A 337
GLU A 334
 3HB  A1341 ( 4.2A)
None
None
None
 0.73A 4v20A-5a3kA:
undetectable		 4v20A-5a3kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		5 / 10 GLY A  32
ALA A  65
VAL A  67
GLU A  66
ILE A  30
 None
 1.21A 5i3cB-5a3kA:
undetectable		 5i3cB-5a3kA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		5 / 7 HIS A 195
HIS A 193
LEU A 224
VAL A 126
SER A 125
 None
 1.46A 5m8rA-5a3kA:
undetectable		 5m8rA-5a3kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		5 / 8 HIS A 195
HIS A 193
LEU A 224
VAL A 126
SER A 125
 None
 1.44A 5m8rD-5a3kA:
undetectable		 5m8rD-5a3kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		4 / 6 ASN A   9
THR A  12
ARG A  28
GLU A  89
 None
 1.30A 5uigA-5a3kA:
undetectable		 5uigA-5a3kA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE
(Streptomyces
hygroscopicus) 		4 / 6 LEU A 185
PRO A 169
HIS A 195
HIS A 193
 None
 1.11A 6pahA-5a3kA:
undetectable		 6pahA-5a3kA:
21.25