SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a3y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 6 TYR A  76
ASP A 138
VAL A 140
GLY A 136
 None
CA  A1318 (-3.2A)
None
None
 1.26A 1ekjC-5a3yA:
undetectable
1ekjD-5a3yA:
undetectable		 1ekjC-5a3yA:
17.10
1ekjD-5a3yA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 6 ASP A 138
VAL A 140
GLY A 136
TYR A  76
 CA  A1318 (-3.2A)
None
None
None
 1.21A 1ekjC-5a3yA:
undetectable
1ekjD-5a3yA:
undetectable		 1ekjC-5a3yA:
17.10
1ekjD-5a3yA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		3 / 3 ALA A  73
VAL A  71
TRP A  55
 None
 0.82A 1grmA-5a3yA:
undetectable		 1grmA-5a3yA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		3 / 3 ALA A  73
VAL A  71
TRP A  55
 None
 0.82A 1grmB-5a3yA:
undetectable		 1grmB-5a3yA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 7 GLY A 162
ALA A 167
THR A 149
SER A 169
 None
None
None
ZN  A1317 ( 4.6A)
 0.87A 1gtfL-5a3yA:
undetectable
1gtfM-5a3yA:
undetectable		 1gtfL-5a3yA:
7.66
1gtfM-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 GLY A 162
ALA A 167
THR A 149
SER A 169
 None
None
None
ZN  A1317 ( 4.6A)
 0.85A 1gtfN-5a3yA:
undetectable
1gtfO-5a3yA:
undetectable		 1gtfN-5a3yA:
7.66
1gtfO-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		3 / 3 ALA A  73
VAL A  71
TRP A  55
 None
 0.92A 1jo4A-5a3yA:
undetectable		 1jo4A-5a3yA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		3 / 3 ALA A  73
VAL A  71
TRP A  55
 None
 0.92A 1jo4B-5a3yA:
undetectable		 1jo4B-5a3yA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 4 ASP A 170
HIS A 142
ARG A 203
GLU A 166
 None
ZN  A1317 (-3.2A)
VAL  A1322 (-2.6A)
ZN  A1317 (-2.3A)
 0.90A 1lqtA-5a3yA:
1.1		 1lqtA-5a3yA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 9 TYR A  81
ILE A 100
GLY A  36
ILE A  39
ALA A  77
 None
 1.13A 1mrgA-5a3yA:
undetectable		 1mrgA-5a3yA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		3 / 3 ALA A  73
VAL A  71
TRP A  55
 None
 0.91A 1nrmA-5a3yA:
undetectable		 1nrmA-5a3yA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		3 / 3 ALA A  73
VAL A  71
TRP A  55
 None
 0.91A 1nrmB-5a3yA:
undetectable		 1nrmB-5a3yA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 GLU A 177
ASN A 183
ASP A  72
GLY A 136
ILE A 137
 CA  A1318 ( 2.3A)
None
None
None
None
 1.36A 1q8jA-5a3yA:
undetectable		 1q8jA-5a3yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ALA A 309
ILE A 244
ALA A 286
LEU A 275
PHE A 267
 None
 1.03A 1udtA-5a3yA:
undetectable		 1udtA-5a3yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ALA A 309
ILE A 244
ALA A 286
LEU A 275
PHE A 267
 None
 1.10A 1uduB-5a3yA:
undetectable		 1uduB-5a3yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.23A 1v7zA-5a3yA:
undetectable		 1v7zA-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.23A 1v7zB-5a3yA:
undetectable		 1v7zB-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.24A 1v7zC-5a3yA:
undetectable		 1v7zC-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.24A 1v7zD-5a3yA:
undetectable		 1v7zD-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.23A 1v7zE-5a3yA:
undetectable		 1v7zE-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.24A 1v7zF-5a3yA:
undetectable		 1v7zF-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 11 ILE A 237
ALA A 240
ALA A 241
LEU A 263
ALA A 309
 None
 1.08A 2aclE-5a3yA:
undetectable		 2aclE-5a3yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ALA A 113
HIS A 142
GLU A 143
HIS A 146
GLU A 166
 VAL  A1322 (-4.8A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
ZN  A1317 (-3.2A)
ZN  A1317 (-2.3A)
 0.51A 2c6nA-5a3yA:
6.0		 2c6nA-5a3yA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ALA A 309
ILE A 244
ALA A 286
LEU A 275
PHE A 267
 None
 1.12A 2h42B-5a3yA:
undetectable		 2h42B-5a3yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ILE A 164
ILE A 168
ALA A 167
ALA A 240
ILE A 244
 None
 0.91A 2h79A-5a3yA:
undetectable		 2h79A-5a3yA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ALA A  68
SER A  65
ALA A  70
GLY A  10
GLY A  12
 None
 0.93A 2igtA-5a3yA:
undetectable		 2igtA-5a3yA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ALA A  68
SER A  65
ALA A  70
GLY A  10
GLY A  12
 None
 0.93A 2igtB-5a3yA:
undetectable		 2igtB-5a3yA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.20A 3a6jA-5a3yA:
undetectable		 3a6jA-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 7 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.19A 3a6jB-5a3yA:
undetectable		 3a6jB-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.19A 3a6jC-5a3yA:
undetectable		 3a6jC-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.20A 3a6jE-5a3yA:
undetectable		 3a6jE-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 8 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.19A 3a6jF-5a3yA:
undetectable		 3a6jF-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 7 SER A 234
SER A 204
GLU A 187
ASP A 185
 None
None
None
CA  A1319 ( 2.8A)
 1.32A 3bc9A-5a3yA:
undetectable		 3bc9A-5a3yA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 10 ALA A 287
LEU A 284
ALA A 167
ILE A 171
LEU A 263
 None
 1.23A 3fl9A-5a3yA:
undetectable		 3fl9A-5a3yA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ILE A 164
ILE A 168
ALA A 167
ALA A 240
ILE A 244
 None
 0.88A 3gwsX-5a3yA:
undetectable		 3gwsX-5a3yA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 9 ILE A 100
ASP A  82
THR A  41
SER A 102
ILE A  20
 None
 1.32A 3hbbB-5a3yA:
undetectable		 3hbbB-5a3yA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 ASN A  60
GLY A   8
ALA A  68
LEU A  30
ILE A  20
 None
 1.13A 3ku1G-5a3yA:
undetectable		 3ku1G-5a3yA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 11 ILE A 164
ALA A 153
SER A 291
ILE A 266
LEU A 284
 None
 1.26A 3qg2B-5a3yA:
undetectable		 3qg2B-5a3yA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 ASP A 138
ASP A 126
GLU A 143
GLU A 190
 CA  A1318 (-3.2A)
None
VAL  A1322 (-3.2A)
CA  A1318 ( 2.2A)
 0.88A 4feuD-5a3yA:
undetectable		 4feuD-5a3yA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 7 TRP A 115
SER A 103
TYR A  42
ARG A 101
 None
 1.37A 4l64A-5a3yA:
undetectable		 4l64A-5a3yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 9 ILE A  39
ILE A  20
THR A  80
ILE A 137
VAL A 140
 None
 1.15A 4nptA-5a3yA:
undetectable		 4nptA-5a3yA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 6 HIS A 142
HIS A 146
TYR A 157
GLU A 166
 ZN  A1317 (-3.2A)
ZN  A1317 (-3.2A)
None
ZN  A1317 (-2.3A)
 0.86A 4pahA-5a3yA:
undetectable		 4pahA-5a3yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 6 LEU A 271
HIS A 146
HIS A 142
GLU A 166
 None
ZN  A1317 (-3.2A)
ZN  A1317 (-3.2A)
ZN  A1317 (-2.3A)
 1.03A 4pahA-5a3yA:
undetectable		 4pahA-5a3yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 GLY A 223
ILE A 236
SER A 234
GLY A 229
 None
 0.83A 5alcL-5a3yA:
undetectable		 5alcL-5a3yA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 12 GLY A 259
ILE A 258
ILE A 168
ALA A 270
LEU A 284
 None
 0.98A 5e72A-5a3yA:
undetectable		 5e72A-5a3yA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.6A)
None
None
 0.86A 5eevL-5a3yA:
undetectable
5eevV-5a3yA:
undetectable		 5eevL-5a3yA:
7.66
5eevV-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.6A)
None
None
 0.86A 5eewL-5a3yA:
undetectable
5eewV-5a3yA:
undetectable		 5eewL-5a3yA:
7.66
5eewV-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.6A)
None
None
 0.86A 5eezL-5a3yA:
undetectable
5eezV-5a3yA:
undetectable		 5eezL-5a3yA:
7.66
5eezV-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.6A)
None
None
 0.86A 5ef1L-5a3yA:
undetectable
5ef1V-5a3yA:
undetectable		 5ef1L-5a3yA:
7.66
5ef1V-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.6A)
None
None
 0.86A 5ef2L-5a3yA:
undetectable
5ef2V-5a3yA:
undetectable		 5ef2L-5a3yA:
7.66
5ef2V-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 THR A 149
SER A 169
GLY A 162
ALA A 167
 None
ZN  A1317 ( 4.6A)
None
None
 0.86A 5ef3L-5a3yA:
undetectable
5ef3V-5a3yA:
undetectable		 5ef3L-5a3yA:
7.66
5ef3V-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		5 / 7 PHE A 267
ILE A 168
ASP A 138
GLY A 173
PHE A 172
 None
None
CA  A1318 (-3.2A)
None
None
 1.21A 5h3aA-5a3yA:
undetectable		 5h3aA-5a3yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 8 GLN A 246
ALA A 309
GLN A 308
SER A 305
 None
 0.94A 5km8A-5a3yA:
undetectable
5km8B-5a3yA:
undetectable		 5km8A-5a3yA:
14.07
5km8B-5a3yA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 4 SER A 134
ALA A  73
GLN A 119
THR A  41
 None
 1.22A 5n0rA-5a3yA:
undetectable		 5n0rA-5a3yA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 4 SER A 134
ALA A  73
GLN A 119
THR A  41
 None
 1.23A 5n0sA-5a3yA:
undetectable		 5n0sA-5a3yA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 5 SER A 134
ALA A  73
GLN A 119
THR A  41
 None
 1.20A 5n0tA-5a3yA:
undetectable		 5n0tA-5a3yA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 4 SER A 134
ALA A  73
GLN A 119
THR A  41
 None
 1.24A 5n0wA-5a3yA:
undetectable		 5n0wA-5a3yA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 5 SER A 134
ALA A  73
GLN A 119
THR A  41
 None
 1.27A 5n0wB-5a3yA:
undetectable		 5n0wB-5a3yA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 4 SER A 134
ALA A  73
GLN A 119
THR A  41
 None
 1.24A 5n0xA-5a3yA:
undetectable		 5n0xA-5a3yA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 5 SER A 134
ALA A  73
GLN A 119
THR A  41
 None
 1.26A 5n4iA-5a3yA:
undetectable		 5n4iA-5a3yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 4 HIS A 142
HIS A 146
TYR A 157
GLU A 166
 ZN  A1317 (-3.2A)
ZN  A1317 (-3.2A)
None
ZN  A1317 (-2.3A)
 0.88A 5pahA-5a3yA:
undetectable		 5pahA-5a3yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 7 GLN A 308
VAL A 306
ALA A 292
THR A 293
 None
 0.94A 6cduH-5a3yA:
undetectable
6cduI-5a3yA:
undetectable		 6cduH-5a3yA:
21.50
6cduI-5a3yA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		3 / 3 PHE A  63
ARG A  11
GLN A  17
 None
 1.02A 6g1pB-5a3yA:
undetectable		 6g1pB-5a3yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5a3y THERMOLYSIN
(Bacillus
thermoproteolyti
cus) 		4 / 6 HIS A 142
HIS A 146
TYR A 157
GLU A 166
 ZN  A1317 (-3.2A)
ZN  A1317 (-3.2A)
None
ZN  A1317 (-2.3A)
 0.87A 6pahA-5a3yA:
undetectable		 6pahA-5a3yA:
19.07