SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5a40 PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Bordetella
pertussis) 		4 / 5 TRP A  66
ILE A  67
LEU A   7
ALA A  11
 None
 1.21A 1xvaA-5a40A:
undetectable
1xvaB-5a40A:
undetectable		 1xvaA-5a40A:
19.03
1xvaB-5a40A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5a40 MONOBODIES
PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Bordetella
pertussis;
Homo
sapiens) 		3 / 3 GLU A  88
HIS E  78
THR A  39
 None
 0.85A 3hkuA-5a40A:
undetectable		 3hkuA-5a40A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5a40 PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Bordetella
pertussis) 		4 / 6 LEU A  40
ASN A  31
SER A 108
PHE A  85
 None
 1.42A 3i9jB-5a40A:
undetectable		 3i9jB-5a40A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5a40 PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Bordetella
pertussis) 		5 / 12 TYR A 104
ALA A  42
GLY A  47
SER A 112
LEU A  79
 None
 1.45A 3ou6D-5a40A:
undetectable		 3ou6D-5a40A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5a40 PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Bordetella
pertussis) 		5 / 12 GLY A  46
ILE A  12
GLY A  19
ALA A  71
ALA A  70
 None
 0.99A 3sufB-5a40A:
undetectable		 3sufB-5a40A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5a40 PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Bordetella
pertussis) 		4 / 6 SER A  59
ALA A  58
HIS A  60
LEU A  56
 None
 1.14A 5dzkB-5a40A:
undetectable
5dzkP-5a40A:
undetectable		 5dzkB-5a40A:
19.82
5dzkP-5a40A:
28.57