SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		5 / 11 VAL A 481
ILE A 461
GLY A 463
ALA A 464
LEU A 468
 None
 1.18A 3n8yA-5a4aA:
undetectable		 3n8yA-5a4aA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		5 / 11 VAL A 456
TRP A 588
GLY A 484
ASN A 540
ILE A 461
 None
 1.12A 3owxA-5a4aA:
undetectable
3owxB-5a4aA:
2.7		 3owxA-5a4aA:
24.21
3owxB-5a4aA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		4 / 9 CYH A 533
HIS A 528
PHE A 568
ILE A 560
 None
 1.33A 4jvlA-5a4aA:
undetectable		 4jvlA-5a4aA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		4 / 8 PHE A 568
HIS A 556
PRO A 522
ILE A 560
 None
 1.10A 5vkqB-5a4aA:
undetectable
5vkqC-5a4aA:
undetectable		 5vkqB-5a4aA:
8.04
5vkqC-5a4aA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		3 / 3 ILE A 461
ASN A 482
CYH A 455
 None
 0.92A 6bp4A-5a4aA:
undetectable		 6bp4A-5a4aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		4 / 4 GLN A 598
THR A 602
THR A 518
LEU A 420
 None
 1.40A 6f3mA-5a4aA:
2.4		 6f3mA-5a4aA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		4 / 4 GLN A 598
THR A 602
THR A 518
LEU A 420
 None
 1.39A 6f3mC-5a4aA:
2.5		 6f3mC-5a4aA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		4 / 5 GLN A 598
THR A 602
THR A 518
LEU A 420
 None
 1.42A 6gbnB-5a4aA:
undetectable		 6gbnB-5a4aA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		5 / 12 VAL A 599
VAL A 596
TRP A 588
ASN A 519
VAL A 481
 None
 1.28A 6iblA-5a4aA:
undetectable		 6iblA-5a4aA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5a4a MATERNAL EFFECT
PROTEIN OSKAR
(Drosophila
melanogaster) 		5 / 12 VAL A 599
VAL A 596
TRP A 588
ASN A 519
VAL A 481
 None
 1.32A 6iblB-5a4aA:
undetectable		 6iblB-5a4aA:
18.53