SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5a4b HUMAN
ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 183
SER A 179
ALA A 188
ASN A 170
TYR A 200
 None
 1.14A 4ymgA-5a4bA:
undetectable		 4ymgA-5a4bA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5a4b HUMAN
ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 12 GLY A 183
SER A 179
ALA A 188
ASN A 170
TYR A 200
 None
 1.14A 4ymgB-5a4bA:
undetectable		 4ymgB-5a4bA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5a4b HUMAN
ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 5 ILE A 190
GLY A 183
ILE A 198
LEU A 186
 None
 0.88A 5dzki-5a4bA:
undetectable
5dzkj-5a4bA:
undetectable
5dzkx-5a4bA:
undetectable		 5dzki-5a4bA:
23.40
5dzkj-5a4bA:
23.40
5dzkx-5a4bA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5a4b HUMAN
ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 8 PHE A  66
GLY A  69
THR A  45
PHE A 141
 None
 0.94A 5flcB-5a4bA:
undetectable		 5flcB-5a4bA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5a4b HUMAN
ALPHA-ACTININ-2
(Homo
sapiens) 		4 / 8 PHE A  66
GLY A  69
THR A  45
PHE A 141
 None
 0.94A 5flcF-5a4bA:
undetectable		 5flcF-5a4bA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a4b HUMAN
ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 10 ILE A 134
ILE A 138
LEU A 139
ILE A 122
ASN A 126
 None
 1.24A 5vkqA-5a4bA:
undetectable
5vkqD-5a4bA:
undetectable		 5vkqA-5a4bA:
8.38
5vkqD-5a4bA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a4b HUMAN
ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 10 ILE A 122
ASN A 126
ILE A 134
ILE A 138
LEU A 139
 None
 1.25A 5vkqA-5a4bA:
undetectable
5vkqB-5a4bA:
undetectable		 5vkqA-5a4bA:
8.38
5vkqB-5a4bA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a4b HUMAN
ALPHA-ACTININ-2
(Homo
sapiens) 		5 / 10 ILE A 122
ASN A 126
ILE A 134
ILE A 138
LEU A 139
 None
 1.24A 5vkqC-5a4bA:
undetectable
5vkqD-5a4bA:
undetectable		 5vkqC-5a4bA:
8.38
5vkqD-5a4bA:
8.38