SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 ASP A  43
ASP A 252
ASP A  30
 EDO  A1562 (-2.9A)
None
None
 0.71A 1eizA-5a4jA:
2.3		 1eizA-5a4jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 ASP A  43
ASP A 252
ASP A  30
 EDO  A1562 (-2.9A)
None
None
 0.70A 1ej0A-5a4jA:
2.2		 1ej0A-5a4jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 279
ALA A 278
PHE A 274
GLY A 280
 None
 1.43A 1mj2B-5a4jA:
undetectable		 1mj2B-5a4jA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 279
ALA A 278
PHE A 274
GLY A 280
 None
 1.35A 1mj2D-5a4jA:
undetectable		 1mj2D-5a4jA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 279
ALA A 278
PHE A 274
GLY A 280
 None
 1.41A 1mjoA-5a4jA:
undetectable		 1mjoA-5a4jA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 279
ALA A 278
PHE A 274
GLY A 280
 None
 1.40A 1mjoD-5a4jA:
undetectable		 1mjoD-5a4jA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 ILE A  64
VAL A 395
ILE A 429
LEU A 422
VAL A 426
 None
None
PEG  A1563 ( 4.6A)
None
None
 1.01A 1oipA-5a4jA:
undetectable		 1oipA-5a4jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 THR A  61
GLY A  81
ASP A  82
ALA A 267
 None
 1.20A 1sg9A-5a4jA:
undetectable		 1sg9A-5a4jA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 6 ILE A  93
VAL A 298
VAL A 366
ILE A  64
 None
 0.80A 1uwhA-5a4jA:
undetectable		 1uwhA-5a4jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 ARG A 505
ASN A 405
THR A 370
 None
None
PEG  A1563 (-4.0A)
 0.79A 2q63A-5a4jA:
undetectable		 2q63A-5a4jA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 ASP A 197
ASN A 276
ILE A 226
ILE A 163
TRP A 165
 None
 1.35A 2qmjA-5a4jA:
2.7		 2qmjA-5a4jA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 5 GLN A 117
ALA A  10
GLN A  11
ILE A   9
 None
 1.34A 2z0aA-5a4jA:
undetectable		 2z0aA-5a4jA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 9 GLY A 418
GLY A 415
LEU A  87
LEU A  84
ALA A 423
 None
 0.99A 2z0yA-5a4jA:
undetectable		 2z0yA-5a4jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 9 GLY A 418
GLY A 415
LEU A  87
LEU A  84
ALA A 423
 None
 0.95A 2z0yB-5a4jA:
undetectable		 2z0yB-5a4jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 PHE A 274
ASN A 276
PHE A 303
 None
None
EDO  A1560 ( 4.2A)
 1.01A 2zbuD-5a4jA:
2.6		 2zbuD-5a4jA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 VAL A 200
ARG A  96
HIS A 279
PHE A 274
 None
EDO  A1560 (-3.0A)
None
None
 1.30A 3apwA-5a4jA:
0.0		 3apwA-5a4jA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.05A 3ln1A-5a4jA:
undetectable		 3ln1A-5a4jA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.04A 3ln1B-5a4jA:
undetectable		 3ln1B-5a4jA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.05A 3ln1C-5a4jA:
undetectable		 3ln1C-5a4jA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.03A 3ln1D-5a4jA:
undetectable		 3ln1D-5a4jA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 5 GLU A 310
LEU A 307
HIS A 365
GLY A 304
 None
 1.16A 3pp1A-5a4jA:
undetectable		 3pp1A-5a4jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 HIS A 279
GLY A 280
ILE A 285
GLY A 271
ALA A 211
 None
 0.96A 3sudC-5a4jA:
undetectable		 3sudC-5a4jA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 HIS A 279
GLY A 280
ILE A 285
GLY A 271
ALA A 211
 None
 0.92A 3sufB-5a4jA:
undetectable		 3sufB-5a4jA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 GLY A  70
GLU A 300
LEU A  95
GLN A 117
ALA A 110
 None
GOL  A1565 ( 4.5A)
None
None
None
 1.19A 3t7vA-5a4jA:
2.2		 3t7vA-5a4jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 11 THR A 236
ALA A 237
PHE A 482
VAL A 485
ILE A 518
 None
 1.15A 4claA-5a4jA:
undetectable		 4claA-5a4jA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 8 HIS A 365
ASN A 361
ARG A 505
ASN A  65
 None
 1.02A 4l7iA-5a4jA:
undetectable		 4l7iA-5a4jA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 8 MET A 205
ALA A 206
PHE A 312
THR A 299
 None
 1.03A 4ltwA-5a4jA:
undetectable		 4ltwA-5a4jA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 8 ALA A  83
ILE A 430
THR A  61
VAL A 330
 None
 0.83A 4r20A-5a4jA:
undetectable		 4r20A-5a4jA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 SER A 283
GLY A 272
GLY A 271
ALA A 286
ASP A 131
 None
 1.31A 4ubeA-5a4jA:
undetectable		 4ubeA-5a4jA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 5 TYR A  44
LYS A 255
PRO A 256
GLU A  33
 EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
 0.76A 4w5tA-5a4jA:
undetectable		 4w5tA-5a4jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 CYH A 399
ALA A 331
VAL A 379
ALA A 406
ILE A  64
 None
 1.02A 4x1yD-5a4jA:
4.4		 4x1yD-5a4jA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 LEU A 336
ALA A 331
VAL A 379
ALA A 406
ILE A  64
 None
 1.07A 4x1yD-5a4jA:
4.4		 4x1yD-5a4jA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 GLU A 300
LEU A  80
THR A  77
THR A  76
VAL A 426
 GOL  A1565 ( 4.5A)
None
None
None
None
 1.11A 4xiwB-5a4jA:
undetectable
4xiwE-5a4jA:
undetectable		 4xiwB-5a4jA:
16.85
4xiwE-5a4jA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 ALA A 267
THR A 265
LEU A  95
MET A 121
PRO A 120
 None
 0.92A 4ypmA-5a4jA:
undetectable		 4ypmA-5a4jA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 6 TYR A  44
LYS A 255
PRO A 256
GLU A  33
 EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
 0.83A 4z4cA-5a4jA:
6.6		 4z4cA-5a4jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 TYR A  44
LYS A 255
PRO A 256
GLU A  33
 EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
 0.70A 4z4fA-5a4jA:
6.5		 4z4fA-5a4jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 6 TYR A  44
LYS A 255
PRO A 256
GLU A  33
 EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
 0.79A 4z4gA-5a4jA:
3.9		 4z4gA-5a4jA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 PHE A 132
ASP A 170
GLY A 272
THR A 199
 None
 0.99A 4zxiA-5a4jA:
3.5		 4zxiA-5a4jA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 6 SER A 283
HIS A 270
MET A 205
LEU A 217
 None
 0.98A 5dzke-5a4jA:
undetectable
5dzks-5a4jA:
undetectable		 5dzke-5a4jA:
18.66
5dzks-5a4jA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.06A 5kirA-5a4jA:
undetectable		 5kirA-5a4jA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 VAL A 327
ALA A 331
GLY A 308
ALA A 309
LEU A 313
 None
 1.12A 5kirB-5a4jA:
undetectable		 5kirB-5a4jA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		6 / 12 GLY A 105
ARG A  96
GLY A 272
VAL A 200
GLY A 109
GLY A 108
 None
EDO  A1560 (-3.0A)
None
None
None
None
 1.11A 5koxA-5a4jA:
undetectable		 5koxA-5a4jA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 9 GLY A 418
GLY A 415
LEU A  87
LEU A  84
ALA A 423
 None
 1.02A 5o96A-5a4jA:
undetectable
5o96B-5a4jA:
undetectable		 5o96A-5a4jA:
17.53
5o96B-5a4jA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 VAL A 487
ILE A 489
VAL A 516
ALA A 527
 None
 0.70A 5osrA-5a4jA:
undetectable		 5osrA-5a4jA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 TYR A  44
LYS A 255
PRO A 256
GLU A  33
 EDO  A1562 (-4.5A)
EDO  A1562 (-3.2A)
None
None
 0.62A 5t7bA-5a4jA:
6.4		 5t7bA-5a4jA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 5 ASN A 257
VAL A 297
LEU A 291
SER A 283
 None
 1.23A 6a7pA-5a4jA:
undetectable		 6a7pA-5a4jA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 ALA A 354
LEU A 336
VAL A 407
LEU A 347
ALA A  69
 None
 1.13A 6djzC-5a4jA:
undetectable		 6djzC-5a4jA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 5a4j FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 11 VAL A 269
PHE A 132
ILE A 198
VAL A 200
MET A 205
 None
 1.38A 6hcoA-5a4jA:
undetectable
6hcoB-5a4jA:
1.1		 6hcoA-5a4jA:
22.96
6hcoB-5a4jA:
22.96