SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 5 GLU S  22
THR S  18
HIS S  13
LEU S  48
 None
 1.29A 1d4fC-5a4mS:
3.5		 1d4fC-5a4mS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 5 ILE S  12
ILE S 160
ILE S 109
LEU S  48
 None
 0.90A 1zgyA-5a4mS:
undetectable		 1zgyA-5a4mS:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 6 ARG S 174
ASN S 228
PRO S 147
ALA S 253
 None
F3S  S 402 (-4.5A)
None
F3S  S 402 ( 4.3A)
 1.27A 2ejfB-5a4mS:
undetectable		 2ejfB-5a4mS:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 8 ALA S 158
ILE S 159
PRO S 170
PRO S 178
 None
 0.81A 3fxrA-5a4mS:
undetectable		 3fxrA-5a4mS:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 VAL S 146
ALA S 253
ILE S 186
THR S 233
SER S 232
 None
F3S  S 402 ( 4.3A)
F3S  S 402 ( 4.7A)
None
None
 1.39A 3hbbB-5a4mS:
undetectable		 3hbbB-5a4mS:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 7 ILE S 110
LEU S  42
THR S  18
ARG S  26
 None
 1.19A 3nxuA-5a4mS:
undetectable		 3nxuA-5a4mS:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
 None
 1.06A 3p4wB-5a4mS:
undetectable		 3p4wB-5a4mS:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 10 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
 None
 1.05A 3p4wD-5a4mS:
undetectable		 3p4wD-5a4mS:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 10 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
 None
 1.05A 3p4wE-5a4mS:
undetectable		 3p4wE-5a4mS:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 5 ALA S 116
GLU S  76
ALA S  74
MET S 156
 None
SF3  S 404 ( 4.7A)
None
None
 1.42A 3r9tC-5a4mS:
undetectable		 3r9tC-5a4mS:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 8 ILE S 138
ASP S 135
ILE S 134
SER S  90
GLY S  14
 None
 1.46A 4acbC-5a4mS:
5.1		 4acbC-5a4mS:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 12 ASP S 188
HIS S 187
PRO S 224
PHE S 196
TYR S 217
 None
SF4  S 401 (-3.0A)
SF4  S 401 ( 4.5A)
None
None
 1.44A 5ef8A-5a4mS:
undetectable		 5ef8A-5a4mS:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5a4m HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 7 ILE S 159
ILE S 160
MET S 163
ILE S  72
 None
 0.84A 5murB-5a4mS:
undetectable		 5murB-5a4mS:
11.87