SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		4 / 6 LEU A 313
TYR A 310
ARG A 245
ILE A 249
 PEG  A1332 (-4.9A)
None
None
None
 0.97A 2q8hA-5a4pA:
undetectable		 2q8hA-5a4pA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		3 / 3 ARG A 103
ILE A 160
TRP A 200
 None
 1.17A 3e68A-5a4pA:
undetectable		 3e68A-5a4pA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		5 / 12 LEU A 167
PHE A 181
ILE A 135
ALA A 133
ILE A 206
 None
 1.02A 3nxuA-5a4pA:
undetectable		 3nxuA-5a4pA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		5 / 12 LEU A 167
PHE A 181
ILE A 135
ALA A 133
ILE A 206
 None
 1.04A 3nxuB-5a4pA:
undetectable		 3nxuB-5a4pA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		5 / 12 MET A 217
LEU A 167
PHE A 181
ILE A 135
ALA A 133
 None
 0.73A 3nxuB-5a4pA:
undetectable		 3nxuB-5a4pA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		5 / 12 MET A 217
LEU A 167
PHE A 181
ILE A 135
ILE A 131
 None
 0.91A 3nxuB-5a4pA:
undetectable		 3nxuB-5a4pA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		5 / 10 THR A 218
PRO A 179
ASN A 220
HIS A 223
TYR A 240
 None
 1.42A 3pp7B-5a4pA:
undetectable		 3pp7B-5a4pA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		4 / 7 VAL A 165
ILE A 213
THR A 169
THR A 170
 None
 0.78A 3tneB-5a4pA:
undetectable		 3tneB-5a4pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		4 / 8 VAL A 187
LEU A 189
LEU A 192
MET A 119
 None
 0.84A 3u5kA-5a4pA:
undetectable		 3u5kA-5a4pA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		4 / 8 VAL A 187
LEU A 189
LEU A 192
MET A 119
 None
 0.88A 3u5kD-5a4pA:
undetectable		 3u5kD-5a4pA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		5 / 12 LEU A 192
ILE A 104
ILE A 206
VAL A 209
LEU A 210
 None
 0.98A 3w67B-5a4pA:
undetectable		 3w67B-5a4pA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z
(Homo
sapiens) 		5 / 12 LEU A 192
ILE A 104
ILE A 206
VAL A 209
LEU A 210
 None
 0.88A 3w68D-5a4pA:
undetectable		 3w68D-5a4pA:
22.73