SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 125
GLY C 227
PHE C 165
LEU C  52
PHE C 102
 None
 1.24A 1pj7A-5a53C:
undetectable		 1pj7A-5a53C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 VAL C 135
THR C 134
GLN C 179
ILE C 226
 None
 1.34A 1ss4A-5a53C:
undetectable		 1ss4A-5a53C:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 PHE C 102
LEU C 230
MET C  90
SER C  92
 None
 1.35A 1wrkB-5a53C:
undetectable		 1wrkB-5a53C:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 160
PHE C 102
ARG C 202
 None
 0.85A 1xdkF-5a53C:
undetectable		 1xdkF-5a53C:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		3 / 3 LEU C  86
LEU C  89
MET C  90
 None
 0.86A 2itzA-5a53C:
undetectable		 2itzA-5a53C:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 PHE C 164
PHE C 165
PHE C 201
VAL C  88
 None
 1.20A 2lh6A-5a53C:
undetectable		 2lh6A-5a53C:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER C 159
ASP A  22
ASP B  98
 None
 0.74A 2plwA-5a53C:
undetectable		 2plwA-5a53C:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		5 / 12 ILE C  33
SER C  50
LEU C  31
ALA C  30
CYH C  38
 None
 1.06A 3dzyA-5a53C:
undetectable		 3dzyA-5a53C:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 8 LYS A  51
TYR C 204
LEU C 206
SER C 183
 None
 1.03A 3lm8A-5a53A:
undetectable
3lm8C-5a53A:
undetectable		 3lm8A-5a53A:
18.06
3lm8C-5a53A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 4 LYS C 138
LEU C  86
MET C 184
ARG B 101
 None
 1.31A 4bkjA-5a53C:
undetectable		 4bkjA-5a53C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 LYS C 138
LEU C  86
MET C 184
ARG B 101
 None
 1.33A 4bkjB-5a53C:
undetectable		 4bkjB-5a53C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 0.91A 4d39A-5a53C:
undetectable		 4d39A-5a53C:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 0.94A 4d39B-5a53C:
undetectable		 4d39B-5a53C:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		5 / 12 GLY C  35
ILE C 182
PHE C 232
THR C  91
MET C 100
 None
 1.17A 4zdyA-5a53C:
undetectable		 4zdyA-5a53C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		5 / 12 GLY C  35
ILE C 182
PHE C 232
THR C  91
MET C 100
 None
 1.22A 5eslA-5a53C:
undetectable		 5eslA-5a53C:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 ALA C 147
VAL C 153
PHE C 190
ILE C 234
 None
 1.01A 5of1A-5a53C:
undetectable		 5of1A-5a53C:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 ALA C 147
VAL C 153
PHE C 190
ILE C 234
 None
 0.93A 5of1B-5a53C:
undetectable		 5of1B-5a53C:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 1.04A 5vunA-5a53C:
undetectable		 5vunA-5a53C:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 1.01A 5vuoB-5a53C:
undetectable		 5vuoB-5a53C:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 0.96A 6auuB-5a53C:
undetectable		 6auuB-5a53C:
19.53