SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5a5c LRRTM
(synthetic
construct) 		4 / 8 LEU A 152
PHE A 154
LEU A 179
LEU A 176
 None
 0.88A 1e7cA-5a5cA:
undetectable		 1e7cA-5a5cA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5a5c LRRTM
(synthetic
construct) 		5 / 12 LEU A  83
LEU A  59
LEU A  35
LEU A  69
LEU A  66
 None
 1.07A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5a5c LRRTM
(synthetic
construct) 		5 / 12 LEU A 107
LEU A  83
LEU A  59
LEU A  93
LEU A  90
 None
 1.02A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5a5c LRRTM
(synthetic
construct) 		5 / 12 LEU A 131
LEU A 107
LEU A  83
LEU A 117
LEU A 114
 None
 1.07A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5a5c LRRTM
(synthetic
construct) 		5 / 12 LEU A 155
LEU A 131
LEU A 107
LEU A 141
LEU A 138
 None
 1.07A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5a5c LRRTM
(synthetic
construct) 		5 / 12 LEU A 251
LEU A 227
LEU A 203
LEU A 237
LEU A 234
 None
 1.01A 1sqnB-5a5cA:
undetectable		 1sqnB-5a5cA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5a5c LRRTM
(synthetic
construct) 		5 / 9 LEU A 157
LEU A 141
VAL A 121
LEU A 128
PHE A 146
 None
 1.18A 1tbfA-5a5cA:
undetectable		 1tbfA-5a5cA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5a5c LRRTM
(synthetic
construct) 		5 / 9 LEU A 229
LEU A 213
VAL A 193
LEU A 200
PHE A 218
 None
 1.24A 1tbfA-5a5cA:
undetectable		 1tbfA-5a5cA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5a5c LRRTM
(synthetic
construct) 		4 / 7 THR A  97
LEU A 107
LEU A  85
LEU A  83
 None
 0.93A 3bgdB-5a5cA:
undetectable		 3bgdB-5a5cA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5a5c LRRTM
(synthetic
construct) 		5 / 12 LEU A  42
VAL A  24
PHE A  74
LEU A  56
VAL A  73
 None
 1.21A 4ib4A-5a5cA:
undetectable		 4ib4A-5a5cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5a5c LRRTM
(synthetic
construct) 		4 / 5 ASN A  64
LEU A  66
SER A  87
ASN A 136
 None
 1.12A 4n09C-5a5cA:
undetectable		 4n09C-5a5cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5a5c LRRTM
(synthetic
construct) 		5 / 12 LEU A  42
VAL A  24
PHE A  74
LEU A  56
VAL A  73
 None
 1.20A 4nc3A-5a5cA:
undetectable		 4nc3A-5a5cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5a5c LRRTM
(synthetic
construct) 		4 / 8 SER A 305
LEU A 307
ASP A 318
ASP A 321
 None
 1.01A 4umjA-5a5cA:
undetectable		 4umjA-5a5cA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMW_A_PNNA305_0
(BETA-LACTAMASE
TOHO-1)		 5a5c LRRTM
(synthetic
construct) 		4 / 4 ASN A 119
PRO A 142
ASN A 143
ASP A 147
 None
 1.25A 5kmwA-5a5cA:
0.0		 5kmwA-5a5cA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMW_A_PNNA305_0
(BETA-LACTAMASE
TOHO-1)		 5a5c LRRTM
(synthetic
construct) 		4 / 4 ASN A 215
PRO A 238
ASN A 239
ASP A 243
 None
 1.25A 5kmwA-5a5cA:
0.0		 5kmwA-5a5cA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5a5c LRRTM
(synthetic
construct) 		5 / 12 LEU A  42
VAL A  24
PHE A  74
LEU A  56
VAL A  73
 None
 1.16A 5tudA-5a5cA:
undetectable		 5tudA-5a5cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a5c LRRTM
(synthetic
construct) 		4 / 5 TRP A 207
THR A 230
ASN A 255
LEU A 237
 None
 1.46A 5vkqA-5a5cA:
undetectable
5vkqB-5a5cA:
undetectable		 5vkqA-5a5cA:
12.51
5vkqB-5a5cA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a5c LRRTM
(synthetic
construct) 		4 / 5 TRP A 207
THR A 230
ASN A 255
LEU A 237
 None
 1.45A 5vkqB-5a5cA:
undetectable
5vkqC-5a5cA:
undetectable		 5vkqB-5a5cA:
12.51
5vkqC-5a5cA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a5c LRRTM
(synthetic
construct) 		4 / 5 TRP A 207
THR A 230
ASN A 255
LEU A 237
 None
 1.44A 5vkqC-5a5cA:
undetectable
5vkqD-5a5cA:
undetectable		 5vkqC-5a5cA:
12.51
5vkqD-5a5cA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5a5c LRRTM
(synthetic
construct) 		4 / 4 ASN A 255
LEU A 237
TRP A 207
THR A 230
 None
 1.45A 5vkqA-5a5cA:
0.0
5vkqD-5a5cA:
0.0		 5vkqA-5a5cA:
12.51
5vkqD-5a5cA:
12.51