SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 LEU A 428
ALA A 376
THR A 369
VAL A 365
 None
 1.02A 1dvxB-5a5gA:
undetectable		 1dvxB-5a5gA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 ASP A  43
ASP A 251
ASP A  30
 None
 0.69A 1eizA-5a5gA:
undetectable		 1eizA-5a5gA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 ASP A  43
ASP A 251
ASP A  30
 None
 0.69A 1ej0A-5a5gA:
undetectable		 1ej0A-5a5gA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 GLY A  87
ALA A  82
ALA A  79
THR A  90
ILE A  58
 None
 0.89A 1gtnL-5a5gA:
undetectable
1gtnV-5a5gA:
undetectable		 1gtnL-5a5gA:
10.41
1gtnV-5a5gA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 9 ALA A 379
VAL A 410
GLY A 418
ILE A  58
ILE A 327
 None
 0.81A 1hshB-5a5gA:
undetectable		 1hshB-5a5gA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 278
ALA A 277
PHE A 273
GLY A 279
 None
 1.42A 1mj2B-5a5gA:
undetectable		 1mj2B-5a5gA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 278
ALA A 277
PHE A 273
GLY A 279
 None
 1.34A 1mj2D-5a5gA:
undetectable		 1mj2D-5a5gA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 278
ALA A 277
PHE A 273
GLY A 279
 None
 1.39A 1mjoB-5a5gA:
undetectable		 1mjoB-5a5gA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 278
ALA A 277
PHE A 273
GLY A 279
 None
 1.38A 1mjoA-5a5gA:
undetectable		 1mjoA-5a5gA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 HIS A 278
ALA A 277
PHE A 273
GLY A 279
 None
 1.39A 1mjoD-5a5gA:
undetectable		 1mjoD-5a5gA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 11 ALA A 115
VAL A 410
VAL A 297
LEU A  86
ALA A 422
 None
 1.17A 1n4hA-5a5gA:
undetectable		 1n4hA-5a5gA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 PRO A 233
ASP A 228
ASP A 238
 None
 0.80A 1sqfA-5a5gA:
undetectable		 1sqfA-5a5gA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 ALA A  79
THR A  90
ILE A  58
GLY A  87
ALA A  82
 None
 0.91A 1utdL-5a5gA:
undetectable
1utdM-5a5gA:
undetectable		 1utdL-5a5gA:
10.41
1utdM-5a5gA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 ALA A  79
THR A  90
ILE A  58
GLY A  87
ALA A  82
 None
 0.91A 1utdO-5a5gA:
undetectable
1utdP-5a5gA:
undetectable		 1utdO-5a5gA:
10.41
1utdP-5a5gA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 11 ALA A  79
THR A  90
ILE A  58
GLY A  87
ALA A  82
 None
 0.91A 1utdP-5a5gA:
undetectable
1utdQ-5a5gA:
undetectable		 1utdP-5a5gA:
10.41
1utdQ-5a5gA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 10 GLU A 388
LEU A 391
GLU A 423
ILE A 419
LEU A 407
 None
 1.18A 1wopA-5a5gA:
undetectable		 1wopA-5a5gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 11 GLY A  78
THR A  76
LEU A 425
TYR A 295
VAL A 297
 None
 1.45A 2uvnB-5a5gA:
undetectable		 2uvnB-5a5gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 10 LEU A 421
GLY A 417
LEU A 425
LEU A  83
ALA A  79
 None
 0.98A 2v3kA-5a5gA:
undetectable		 2v3kA-5a5gA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 8 TYR A 337
LEU A 341
LEU A 346
ALA A 344
 None
 0.97A 2wekA-5a5gA:
undetectable		 2wekA-5a5gA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 8 VAL A 377
LEU A  86
GLY A 418
ALA A  82
 None
 0.93A 2xfsA-5a5gA:
undetectable		 2xfsA-5a5gA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 4 VAL A 199
ARG A  95
HIS A 278
PHE A 273
 None
 1.43A 3apwA-5a5gA:
0.0		 3apwA-5a5gA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 8 GLY A 462
ALA A 463
ASP A 464
THR A 531
ILE A 513
 None
 1.42A 3el0A-5a5gA:
undetectable		 3el0A-5a5gA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 MET A 537
MET A 204
PHE A 195
 None
 1.32A 3gn8A-5a5gA:
undetectable		 3gn8A-5a5gA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		3 / 3 THR A 469
LYS A 310
GLU A 475
 None
 0.86A 3ijdB-5a5gA:
3.2		 3ijdB-5a5gA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 GLU A 309
ARG A 454
VAL A 466
ILE A 453
GLU A 450
 None
 1.20A 3jb2A-5a5gA:
undetectable		 3jb2A-5a5gA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 ASN A 360
GLY A 506
ASN A 367
VAL A 371
GLY A 462
 None
 1.26A 3k13B-5a5gA:
undetectable		 3k13B-5a5gA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 12 GLY A 506
ASN A 367
VAL A 371
GLY A 462
SER A 509
 None
 1.19A 3k13B-5a5gA:
undetectable		 3k13B-5a5gA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 LEU A 428
ALA A 376
THR A 369
VAL A 365
 None
 1.03A 3ozkB-5a5gA:
undetectable		 3ozkB-5a5gA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 LEU A 253
GLY A 129
GLU A  96
ALA A 133
 None
None
K  A1562 (-4.0A)
None
 0.85A 3tehB-5a5gA:
undetectable		 3tehB-5a5gA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 PRO A 384
GLU A 388
LEU A 391
LEU A 407
 None
 0.93A 4iomA-5a5gA:
60.0		 4iomA-5a5gA:
66.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 PRO A 384
GLU A 388
LEU A 391
TRP A 411
 None
 0.44A 4iomA-5a5gA:
60.0		 4iomA-5a5gA:
66.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 8 MET A 204
ALA A 205
PHE A 311
THR A 298
 None
 0.97A 4ltwA-5a5gA:
undetectable		 4ltwA-5a5gA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 5 TYR A  44
LYS A 254
PRO A 255
LEU A  46
 None
 1.40A 4w5qA-5a5gA:
5.7		 4w5qA-5a5gA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 9 ALA A  82
LEU A 428
LEU A 421
LEU A 425
ARG A 427
 None
 1.12A 4x30A-5a5gA:
undetectable		 4x30A-5a5gA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 6 TYR A  44
LYS A 254
PRO A 255
LEU A  46
 None
 1.35A 4z4cA-5a5gA:
undetectable		 4z4cA-5a5gA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 5 ASP A 193
TRP A 164
VAL A 163
ALA A 226
 None
 1.49A 5dl9A-5a5gA:
undetectable		 5dl9A-5a5gA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 6 SER A 282
HIS A 269
MET A 204
LEU A 216
 None
 0.93A 5dzke-5a5gA:
undetectable
5dzks-5a5gA:
undetectable		 5dzke-5a5gA:
15.89
5dzks-5a5gA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		6 / 12 GLY A 104
ARG A  95
GLY A 271
VAL A 199
GLY A 108
GLY A 107
 None
 1.11A 5koxA-5a5gA:
undetectable		 5koxA-5a5gA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		4 / 7 VAL A 489
ILE A 491
VAL A 518
ALA A 529
 None
 0.64A 5osrA-5a5gA:
undetectable		 5osrA-5a5gA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 11 VAL A 225
SER A 521
ALA A 236
LEU A 141
ASN A 138
 None
 1.22A 5x6yA-5a5gA:
undetectable		 5x6yA-5a5gA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5a5g FORMATE--TETRAHYDROF
OLATE LIGASE
(Tepidanaerobacte
r
acetatoxydans) 		5 / 11 VAL A 225
SER A 521
ALA A 236
LEU A 141
ASN A 138
 None
 1.19A 5x6yC-5a5gA:
undetectable		 5x6yC-5a5gA:
21.90