SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		3 / 3 GLY A 101
GLU A 100
ASN A 103
 VTB  A1339 ( 4.3A)
VTB  A1339 (-2.9A)
None
 0.68A 1zq9A-5a5lA:
undetectable		 1zq9A-5a5lA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		4 / 5 LEU A 217
ALA A 206
SER A 202
LYS A 134
 None
None
None
VTB  A1339 (-3.6A)
 1.11A 2othA-5a5lA:
1.3		 2othA-5a5lA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		4 / 7 ALA A  36
ALA A  35
ALA A  39
CYH A 105
 None
 0.89A 3a2qA-5a5lA:
undetectable		 3a2qA-5a5lA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		5 / 11 VAL A 320
GLY A   6
ILE A   5
LYS A   0
THR A 323
 None
 1.31A 3bjwB-5a5lA:
1.3		 3bjwB-5a5lA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		3 / 3 MET A  44
VAL A  13
GLU A   8
 None
 0.71A 3c6gA-5a5lA:
undetectable		 3c6gA-5a5lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		5 / 12 LEU A  66
VAL A  54
ILE A  47
VAL A  96
ILE A  53
 None
 1.06A 3d20A-5a5lA:
undetectable		 3d20A-5a5lA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		4 / 8 ARG A 178
ASP A 129
GLU A  57
GLU A 225
 VTB  A1339 (-3.2A)
None
MG  A1341 (-2.8A)
MG  A1342 (-3.0A)
 1.42A 3dh0A-5a5lA:
undetectable		 3dh0A-5a5lA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		4 / 4 ILE A  92
ARG A  43
ILE A  94
THR A 290
 None
 1.04A 3ia4C-5a5lA:
undetectable		 3ia4C-5a5lA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		3 / 3 ARG A  43
ILE A  94
THR A 290
 None
 0.42A 3ia4D-5a5lA:
undetectable		 3ia4D-5a5lA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		5 / 9 ALA A 232
ALA A 231
LEU A 285
LEU A 205
VAL A 201
 None
 1.17A 4or0A-5a5lA:
undetectable		 4or0A-5a5lA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		4 / 6 GLY A  56
GLU A  57
ASP A 129
ASP A  97
 None
MG  A1341 (-2.8A)
None
MG  A1342 (-2.6A)
 0.89A 4uckB-5a5lA:
undetectable		 4uckB-5a5lA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE A  53
ASP A  33
ALA A  17
ALA A  16
VAL A  12
 None
MG  A1341 (-3.3A)
None
None
None
 1.08A 5igjA-5a5lA:
undetectable		 5igjA-5a5lA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Thermosynechococ
cus
elongatus) 		5 / 12 TYR A 280
LEU A 285
ILE A 228
MET A 132
LEU A 268
 None
 1.31A 5ycpA-5a5lA:
undetectable		 5ycpA-5a5lA:
15.81