SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
5 / 10 GLU M  47
ALA M  43
LEU M  42
GLU M  35
GLU M  32
None
1.39A 1a29A-5a5tM:
undetectable
1a29A-5a5tM:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
3 / 3 ASP A 337
ARG A 340
ILE A 348
None
0.64A 1a4gB-5a5tA:
undetectable
1a4gB-5a5tA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 5 PHE A 250
SER A 294
THR A 295
PHE A 291
None
1.40A 1icvA-5a5tA:
undetectable
1icvB-5a5tA:
undetectable
1icvA-5a5tA:
8.82
1icvB-5a5tA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 7 ILE F 272
GLU H 217
LEU F 119
LEU H  44
GLY H  43
None
1.49A 1mt1H-5a5tF:
undetectable
1mt1K-5a5tF:
undetectable
1mt1H-5a5tF:
14.72
1mt1K-5a5tF:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus)
4 / 5 LEU C 675
CYH C 571
ALA C 568
CYH C 567
None
0.84A 1mz9D-5a5tC:
undetectable
1mz9D-5a5tC:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 5 GLU A 421
ARG A 307
LEU A 324
LEU A 299
None
1.11A 1n13B-5a5tA:
undetectable
1n13C-5a5tA:
undetectable
1n13B-5a5tA:
5.60
1n13C-5a5tA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6A_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 10 ILE A 329
ALA A 325
GLU A 423
ASN A 274
HIS A 297
None
1.23A 1n6aA-5a5tA:
undetectable
1n6aA-5a5tA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6A_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 10 ILE A 329
ALA A 325
GLU A 423
LYS A 278
HIS A 297
None
1.44A 1n6aA-5a5tA:
undetectable
1n6aA-5a5tA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
LYS A 278
HIS A 297
None
1.40A 1n6cA-5a5tA:
undetectable
1n6cA-5a5tA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 LYS M 331
VAL A 443
ILE M 325
MET M 277
None
1.15A 1opjA-5a5tM:
undetectable
1opjA-5a5tM:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
3 / 3 VAL A 253
ALA A 252
HIS A 204
None
0.55A 1q23G-5a5tA:
undetectable
1q23G-5a5tA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
3 / 3 VAL A 253
ALA A 252
HIS A 204
None
0.71A 1q23L-5a5tA:
undetectable
1q23L-5a5tA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
3 / 3 VAL A 253
ALA A 252
HIS A 204
None
0.50A 1q23J-5a5tA:
undetectable
1q23J-5a5tA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 8 HIS M 339
ASP M 221
SER M 337
THR M 318
None
1.15A 1rg9A-5a5tM:
undetectable
1rg9A-5a5tM:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 8 HIS M 339
ASP M 221
SER M 337
THR M 318
None
1.14A 1rg9B-5a5tM:
undetectable
1rg9B-5a5tM:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
3 / 3 LYS E 359
ASP C 814
ASP E 306
None
0.97A 2br4D-5a5tE:
undetectable
2br4D-5a5tE:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 9 LEU A 455
PHE A 452
LEU A 440
LEU A 480
ALA A 470
None
1.35A 2bxeA-5a5tA:
undetectable
2bxeA-5a5tA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 10 LEU A 455
PHE A 452
LEU A 440
ILE A 484
ALA A 470
None
1.14A 2bxeB-5a5tA:
2.1
2bxeB-5a5tA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus)
5 / 10 LEU C 594
HIS E  12
LEU C 588
ILE C 573
ALA C 568
None
1.12A 2bxeB-5a5tC:
2.6
2bxeB-5a5tC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.92A 2eijN-5a5tA:
undetectable
2eijW-5a5tA:
undetectable
2eijN-5a5tA:
13.37
2eijW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.92A 2eikN-5a5tA:
undetectable
2eikW-5a5tA:
undetectable
2eikN-5a5tA:
13.37
2eikW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.89A 2eilN-5a5tA:
2.0
2eilW-5a5tA:
undetectable
2eilN-5a5tA:
13.37
2eilW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 11 ILE F 118
GLU F 187
GLU F 265
HIS H  52
THR F 152
None
1.16A 2fn1B-5a5tF:
undetectable
2fn1B-5a5tF:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
5 / 12 ALA H 344
GLN A 522
LEU F 285
LEU M 369
SER M 370
None
1.37A 2nv4B-5a5tH:
undetectable
2nv4B-5a5tH:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus)
5 / 12 ILE E 177
LEU E 173
GLY E 171
ALA E 184
ALA E 185
None
1.00A 2oc8A-5a5tE:
undetectable
2oc8A-5a5tE:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 6 ALA M  43
ASP M  41
GLU M  47
ARG M  19
None
1.19A 2ouzA-5a5tM:
undetectable
2ouzA-5a5tM:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
5 / 12 LEU H 214
ILE H 211
ALA F 120
VAL F 117
ASP H  42
None
1.19A 2qo4A-5a5tH:
undetectable
2qo4A-5a5tH:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
5 / 12 LEU H 214
ILE H 211
ALA F 120
VAL F 117
ASP H  42
None
1.17A 2qo6A-5a5tH:
undetectable
2qo6A-5a5tH:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus)
3 / 3 GLU E  96
GLN E 103
ARG E 102
None
1.00A 2w3bB-5a5tE:
undetectable
2w3bB-5a5tE:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 LEU A  12
LYS A  13
ASN A  16
LEU A  19
None
0.56A 2xn3A-5a5tA:
undetectable
2xn3B-5a5tA:
undetectable
2xn3A-5a5tA:
11.63
2xn3B-5a5tA:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus)
4 / 8 GLN C 648
LEU C 646
LEU C 682
ASN C 678
None
1.17A 2xn3A-5a5tC:
undetectable
2xn3B-5a5tC:
undetectable
2xn3A-5a5tC:
16.67
2xn3B-5a5tC:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
4 / 8 SER F 156
TYR F 259
VAL H 213
VAL F 222
None
0.91A 2y05A-5a5tF:
undetectable
2y05B-5a5tF:
undetectable
2y05A-5a5tF:
21.70
2y05B-5a5tF:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.88A 3ablN-5a5tA:
undetectable
3ablW-5a5tA:
undetectable
3ablN-5a5tA:
13.37
3ablW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.87A 3ag3N-5a5tA:
undetectable
3ag3W-5a5tA:
undetectable
3ag3N-5a5tA:
13.37
3ag3W-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.91A 3asnN-5a5tA:
undetectable
3asnW-5a5tA:
undetectable
3asnN-5a5tA:
13.37
3asnW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 12 MET H 264
ASN H 261
GLY C 864
LEU F 374
ARG C 872
None
1.40A 3cldA-5a5tH:
undetectable
3cldA-5a5tH:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus)
4 / 8 ALA E 245
GLN E 239
TYR E 242
ILE E 253
None
0.88A 3cldB-5a5tE:
undetectable
3cldB-5a5tE:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
3 / 3 ASN M 273
MET M 297
PHE M 311
None
0.82A 3g4lD-5a5tM:
undetectable
3g4lD-5a5tM:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 LYS M 331
VAL A 443
ILE M 325
MET M 277
None
1.15A 3gvuA-5a5tM:
undetectable
3gvuA-5a5tM:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 11 ILE F 272
ILE H  41
LEU H 150
ILE H  49
THR F 264
None
1.08A 3hbbC-5a5tF:
undetectable
3hbbC-5a5tF:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
3 / 3 ARG A 476
ASP A 479
ASP A 473
None
0.82A 3jb2A-5a5tA:
2.0
3jb2A-5a5tA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
3 / 3 ARG A 476
ASP A 479
ASP A 473
None
0.87A 3jb3A-5a5tA:
undetectable
3jb3A-5a5tA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 12 TYR H 263
LEU H 133
VAL H 129
GLN H 137
LEU H 169
None
1.32A 3m7rA-5a5tH:
undetectable
3m7rA-5a5tH:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
5 / 12 ASN M 355
TYR M 351
GLU H 349
ASN H 352
TYR H 350
None
1.28A 3mekA-5a5tM:
4.4
3mekA-5a5tM:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 10 LEU F 328
ALA A 531
VAL F 335
GLY F 293
LEU F 331
None
0.99A 3ogqA-5a5tF:
undetectable
3ogqA-5a5tF:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus)
6 / 9 ILE A 471
ILE A 484
TYR C 795
LEU A 491
LEU A 480
ALA A 474
None
1.32A 3ozvB-5a5tA:
undetectable
3ozvB-5a5tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 LYS M 331
VAL A 443
ILE M 325
MET M 277
None
1.17A 3pyyB-5a5tM:
undetectable
3pyyB-5a5tM:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 SER F 211
GLY F 245
GLU M  12
GLU M  11
None
1.48A 3raeB-5a5tF:
undetectable
3raeD-5a5tF:
undetectable
3raeB-5a5tF:
20.40
3raeD-5a5tF:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus)
4 / 5 ILE K  99
THR K  66
THR K  64
PHE K  61
None
1.09A 3snfA-5a5tK:
undetectable
3snfA-5a5tK:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
5 / 12 GLY A 287
GLU C 722
ARG A 340
LEU C 718
ALA C 740
None
1.25A 3t7vA-5a5tA:
undetectable
3t7vA-5a5tA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus)
4 / 8 TYR C 556
TYR C 503
HIS C 572
LEU C 594
None
0.98A 3uzzB-5a5tC:
undetectable
3uzzB-5a5tC:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
4 / 8 LEU H 134
VAL H 149
TYR H 167
LEU H 169
None
1.04A 3v81C-5a5tH:
undetectable
3v81C-5a5tH:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 6 MET A 306
LEU A 271
GLN A 226
TYR A 275
None
1.40A 3vkxA-5a5tA:
undetectable
3vkxA-5a5tA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus)
4 / 5 GLU E 149
GLY E 146
TYR E 150
ASP E 115
None
1.14A 3w9tD-5a5tE:
undetectable
3w9tD-5a5tE:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 THR A 295
TYR A 300
ARG A 298
LEU A 361
None
1.31A 3wipG-5a5tA:
undetectable
3wipH-5a5tA:
undetectable
3wipG-5a5tA:
9.98
3wipH-5a5tA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 5 THR A 320
LEU A 324
GLU A 423
LYS A 278
None
1.31A 4a3pA-5a5tA:
undetectable
4a3pA-5a5tA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 ILE M 243
ALA M 211
HIS M 339
ARG M 278
None
1.18A 4ac9B-5a5tM:
undetectable
4ac9C-5a5tM:
undetectable
4ac9B-5a5tM:
23.18
4ac9C-5a5tM:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 ILE M 243
ALA M 211
HIS M 339
ARG M 278
None
1.22A 4acaB-5a5tM:
undetectable
4acaC-5a5tM:
undetectable
4acaB-5a5tM:
23.18
4acaC-5a5tM:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
4 / 7 LEU H 134
VAL H 149
TYR H 167
LEU H 169
None
1.00A 4b3qA-5a5tH:
undetectable
4b3qA-5a5tH:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus)
5 / 10 LEU K 165
LEU K 162
GLY K 163
ASP K 136
VAL K 138
None
1.31A 4c9nB-5a5tK:
undetectable
4c9nB-5a5tK:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
3 / 3 LYS H 156
THR H 157
ILE H 330
None
0.93A 4e0fB-5a5tH:
undetectable
4e0fB-5a5tH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
ASN A 274
HIS A 297
None
1.24A 4e47A-5a5tA:
undetectable
4e47A-5a5tA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
ASN A 274
HIS A 297
None
1.19A 4e47B-5a5tA:
undetectable
4e47B-5a5tA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
ASN A 274
HIS A 297
None
1.27A 4e47C-5a5tA:
undetectable
4e47C-5a5tA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_D_SAMD800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 10 ILE A 329
ALA A 325
GLU A 423
LYS A 278
HIS A 297
None
1.40A 4e47D-5a5tA:
undetectable
4e47D-5a5tA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
5 / 11 HIS F 115
ILE H  50
LEU H 150
ASP H  42
GLY H  43
None
1.27A 4fogA-5a5tF:
undetectable
4fogA-5a5tF:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 11 HIS F 115
ILE H  50
LEU H 150
ASP H  42
GLY H  43
None
1.25A 4foxF-5a5tF:
undetectable
4foxF-5a5tF:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus)
3 / 3 LEU C 726
MET A 243
ASP A 255
None
0.77A 4j7xB-5a5tC:
undetectable
4j7xB-5a5tC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
ASN A 274
HIS A 297
None
1.19A 4j83A-5a5tA:
undetectable
4j83A-5a5tA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
LYS A 278
HIS A 297
None
1.37A 4j83A-5a5tA:
undetectable
4j83A-5a5tA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
ASN A 274
HIS A 297
None
1.20A 4jdsA-5a5tA:
undetectable
4jdsA-5a5tA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
ASN A 274
HIS A 297
None
1.20A 4jdsB-5a5tA:
undetectable
4jdsB-5a5tA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
LYS A 278
HIS A 297
None
1.40A 4jdsD-5a5tA:
undetectable
4jdsD-5a5tA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 11 ILE A 329
ALA A 325
GLU A 423
LYS A 278
HIS A 297
None
1.34A 4jlgB-5a5tA:
undetectable
4jlgB-5a5tA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 5 GLN A  79
THR A  42
LEU A  55
LEU A  52
None
1.02A 4lvcB-5a5tA:
undetectable
4lvcB-5a5tA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus)
4 / 5 LEU C 718
ASP A 337
ARG A 340
ILE A 348
None
1.29A 4mwrA-5a5tC:
undetectable
4mwrA-5a5tC:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 12 MET H 264
ASN H 261
GLY C 864
LEU F 374
ARG C 872
None
1.44A 4p6xA-5a5tH:
undetectable
4p6xA-5a5tH:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 143
ASN F 153
HIS F 180
SER F 148
ASN F 186
None
1.25A 4pooB-5a5tF:
undetectable
4pooB-5a5tF:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
4 / 8 LEU H 134
VAL H 149
TYR H 167
LEU H 169
None
1.06A 4q0bA-5a5tH:
undetectable
4q0bA-5a5tH:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus)
4 / 8 ILE K 131
LEU K  71
LEU K 121
PHE K 117
None
0.86A 4qopC-5a5tK:
undetectable
4qopC-5a5tK:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.13A 4qvnH-5a5tF:
undetectable
4qvnI-5a5tF:
undetectable
4qvnH-5a5tF:
20.33
4qvnI-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 10 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.14A 4qvnV-5a5tF:
undetectable
4qvnW-5a5tF:
undetectable
4qvnV-5a5tF:
20.33
4qvnW-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.13A 4qvpH-5a5tF:
undetectable
4qvpI-5a5tF:
undetectable
4qvpH-5a5tF:
20.33
4qvpI-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.14A 4qvpV-5a5tF:
undetectable
4qvpW-5a5tF:
undetectable
4qvpV-5a5tF:
20.33
4qvpW-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.13A 4qvqH-5a5tF:
undetectable
4qvqI-5a5tF:
undetectable
4qvqH-5a5tF:
20.33
4qvqI-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.15A 4qvqV-5a5tF:
undetectable
4qvqW-5a5tF:
undetectable
4qvqV-5a5tF:
20.33
4qvqW-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.13A 4qvvH-5a5tF:
undetectable
4qvvH-5a5tF:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.14A 4qvvV-5a5tF:
undetectable
4qvvV-5a5tF:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.09A 4qvyH-5a5tF:
undetectable
4qvyH-5a5tF:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.10A 4qvyV-5a5tF:
undetectable
4qvyW-5a5tF:
undetectable
4qvyV-5a5tF:
20.33
4qvyW-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.12A 4qw0H-5a5tF:
undetectable
4qw0I-5a5tF:
undetectable
4qw0H-5a5tF:
20.33
4qw0I-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.12A 4qw0V-5a5tF:
undetectable
4qw0W-5a5tF:
undetectable
4qw0V-5a5tF:
20.33
4qw0W-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.12A 4qw1H-5a5tF:
undetectable
4qw1I-5a5tF:
undetectable
4qw1H-5a5tF:
20.33
4qw1I-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.13A 4qw1V-5a5tF:
undetectable
4qw1W-5a5tF:
undetectable
4qw1V-5a5tF:
20.33
4qw1W-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.13A 4qwuH-5a5tF:
undetectable
4qwuI-5a5tF:
0.8
4qwuH-5a5tF:
20.33
4qwuI-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.14A 4qwuV-5a5tF:
0.0
4qwuW-5a5tF:
undetectable
4qwuV-5a5tF:
20.33
4qwuW-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 12 PHE A 152
ALA A 181
GLN A 180
TYR A 174
SER A 227
None
1.31A 4qztC-5a5tA:
undetectable
4qztC-5a5tA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 12 VAL H  39
LEU H  76
VAL H 117
GLY H 118
LEU H 150
None
1.06A 4rrwD-5a5tH:
undetectable
4rrwD-5a5tH:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
5 / 12 VAL H  39
LEU H  76
VAL H 117
GLY H 118
LEU H 150
None
1.06A 4rrzD-5a5tH:
undetectable
4rrzD-5a5tH:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus)
4 / 7 PHE H 194
ARG H 313
ASP H 315
ILE H 319
None
1.33A 5a06B-5a5tH:
undetectable
5a06B-5a5tH:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus)
3 / 3 TYR K  32
THR K  28
THR K  35
None
0.83A 5aoxE-5a5tK:
undetectable
5aoxE-5a5tK:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.13A 5bxnH-5a5tF:
undetectable
5bxnI-5a5tF:
undetectable
5bxnH-5a5tF:
20.33
5bxnI-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
5 / 12 ASN M 355
TYR M 351
GLU H 349
ASN H 352
TYR H 350
None
1.23A 5ccmA-5a5tM:
4.4
5ccmA-5a5tM:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.13A 5cz7V-5a5tF:
undetectable
5cz7W-5a5tF:
undetectable
5cz7V-5a5tF:
20.33
5cz7W-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 11 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.12A 5d0xV-5a5tF:
undetectable
5d0xV-5a5tF:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus)
3 / 3 ARG C 789
LYS C 782
GLU C 785
None
0.83A 5d0yA-5a5tC:
undetectable
5d0yA-5a5tC:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 4 LEU M 241
ILE M 243
GLY M 234
ILE M 208
None
0.88A 5dzk3-5a5tM:
undetectable
5dzkm-5a5tM:
undetectable
5dzk3-5a5tM:
2.82
5dzkm-5a5tM:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
4 / 4 ILE F 206
ILE F 137
ARG F 135
LEU F 205
None
1.40A 5dzkh-5a5tF:
undetectable
5dzkn-5a5tF:
undetectable
5dzkv-5a5tF:
undetectable
5dzkh-5a5tF:
17.98
5dzkn-5a5tF:
17.98
5dzkv-5a5tF:
0.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 ILE M 243
GLY M 234
ILE M 208
LEU M 241
None
0.78A 5dzkB-5a5tM:
undetectable
5dzkI-5a5tM:
undetectable
5dzkW-5a5tM:
undetectable
5dzkB-5a5tM:
22.13
5dzkI-5a5tM:
21.97
5dzkW-5a5tM:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 ILE M 243
GLY M 234
ILE M 208
LEU M 241
None
0.82A 5dzki-5a5tM:
undetectable
5dzkj-5a5tM:
undetectable
5dzkx-5a5tM:
undetectable
5dzki-5a5tM:
21.97
5dzkj-5a5tM:
21.97
5dzkx-5a5tM:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 5 ILE M 243
GLY M 234
ILE M 208
LEU M 241
None
0.76A 5dzkd-5a5tM:
1.5
5dzkk-5a5tM:
undetectable
5dzky-5a5tM:
undetectable
5dzkd-5a5tM:
22.13
5dzkk-5a5tM:
21.97
5dzky-5a5tM:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 4 ILE M 243
GLY M 234
ILE M 208
LEU M 241
None
0.74A 5dzkl-5a5tM:
undetectable
5dzkz-5a5tM:
undetectable
5dzkl-5a5tM:
21.97
5dzkz-5a5tM:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 6 ILE A 446
PHE A 493
PHE A 398
THR A 435
None
1.30A 5g08A-5a5tA:
undetectable
5g08A-5a5tA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus)
3 / 3 ALA K  73
ASN K  76
LEU K  77
None
0.34A 5i1nB-5a5tK:
undetectable
5i1nB-5a5tK:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus)
3 / 3 ALA K  73
ASN K  76
LEU K  77
None
0.36A 5i1oC-5a5tK:
undetectable
5i1oC-5a5tK:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.10A 5l5fH-5a5tF:
undetectable
5l5fI-5a5tF:
undetectable
5l5fH-5a5tF:
20.33
5l5fI-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.11A 5l5fV-5a5tF:
undetectable
5l5fW-5a5tF:
undetectable
5l5fV-5a5tF:
20.33
5l5fW-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.11A 5l66H-5a5tF:
undetectable
5l66I-5a5tF:
undetectable
5l66H-5a5tF:
20.33
5l66I-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus)
5 / 12 THR F 200
GLY F 196
THR F 195
ALA F 194
THR F 221
None
1.11A 5l66V-5a5tF:
undetectable
5l66W-5a5tF:
undetectable
5l66V-5a5tF:
20.33
5l66W-5a5tF:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus)
4 / 5 PHE E 137
THR E 101
MET E 104
GLN E 105
None
0.75A 5m35A-5a5tE:
5.5
5m35A-5a5tE:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 4 GLN A  79
THR A  42
LEU A  55
LEU A  52
None
1.02A 5m5kB-5a5tA:
undetectable
5m5kB-5a5tA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
5 / 12 LEU A 411
VAL A 387
LEU A 390
ILE A 331
LEU A 324
None
1.15A 5og9B-5a5tA:
undetectable
5og9B-5a5tA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
4 / 8 HIS M 339
ASP M 221
SER M 337
THR M 318
None
1.13A 5t8sB-5a5tM:
undetectable
5t8sB-5a5tM:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
3 / 3 ARG F 110
PRO F 254
TYR M 139
None
0.92A 5tzoB-5a5tF:
undetectable
5tzoB-5a5tF:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus)
4 / 9 HIS C 845
TYR C 795
ILE C 826
ILE C 827
None
0.78A 5vkqB-5a5tC:
3.2
5vkqC-5a5tC:
3.1
5vkqB-5a5tC:
18.88
5vkqC-5a5tC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
5 / 12 GLY F 325
ASN F 322
HIS M 339
PHE M 282
GLN M 345
None
1.48A 5vseA-5a5tF:
undetectable
5vseA-5a5tF:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus)
5 / 11 VAL M 130
GLY M  96
GLU M  95
SER M 100
LEU M 103
None
1.09A 5x6yC-5a5tM:
undetectable
5x6yC-5a5tM:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 6 HIS A 204
ASN A 222
VAL A 170
LEU A 173
None
1.14A 5xdhA-5a5tA:
undetectable
5xdhC-5a5tA:
undetectable
5xdhA-5a5tA:
4.18
5xdhC-5a5tA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.92A 5xdxN-5a5tA:
undetectable
5xdxW-5a5tA:
undetectable
5xdxN-5a5tA:
13.37
5xdxW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.91A 5zcoA-5a5tA:
1.9
5zcoJ-5a5tA:
undetectable
5zcoA-5a5tA:
13.37
5zcoJ-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 8 ILE A 484
LEU A 491
PHE A 452
LEU A 440
None
0.91A 5zcqN-5a5tA:
undetectable
5zcqW-5a5tA:
undetectable
5zcqN-5a5tA:
13.37
5zcqW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus)
5 / 12 SER E  46
TRP E 170
THR E 190
LEU E 178
PHE E 220
None
1.41A 6a93A-5a5tE:
undetectable
6a93A-5a5tE:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
3 / 3 ALA M 131
PHE F 106
GLN M 138
None
0.69A 6eceA-5a5tM:
undetectable
6eceA-5a5tM:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
4 / 8 HIS H 238
ARG F 266
HIS H 228
ASP F 263
None
1.17A 6mn4D-5a5tH:
undetectable
6mn4D-5a5tH:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus)
4 / 7 TRP E 170
ARG E 191
ASP E 188
GLU E 149
None
1.32A 6mn4F-5a5tE:
undetectable
6mn4F-5a5tE:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus)
4 / 7 HIS H 238
ARG F 266
HIS H 228
ASP F 263
None
1.32A 6mn4F-5a5tH:
undetectable
6mn4F-5a5tH:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 7 ASP A 162
ARG A 158
ASP A  88
GLU A  56
None
1.34A 6mn5B-5a5tA:
undetectable
6mn5B-5a5tA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus)
4 / 6 ASP A 162
ARG A 158
ASP A  88
GLU A  56
None
1.41A 6mn5D-5a5tA:
undetectable
6mn5D-5a5tA:
5.02