SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 12 GLY I 291
GLY I 271
GLY I 294
GLU I 270
LYS I   5
 None
 0.99A 2oxtC-5a5uI:
undetectable		 2oxtC-5a5uI:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 6 ILE I 253
TYR I 234
LYS I 280
ILE I 286
 None
 1.14A 3eteA-5a5uI:
undetectable
3eteE-5a5uI:
undetectable		 3eteA-5a5uI:
22.20
3eteE-5a5uI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 7 LYS I 280
ILE I 286
ILE I 253
TYR I 234
 None
 1.13A 3eteD-5a5uI:
undetectable
3eteF-5a5uI:
undetectable		 3eteD-5a5uI:
22.20
3eteF-5a5uI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 5 GLU I 313
LEU I  13
HIS I 292
GLY I 311
 None
 0.99A 3pp1A-5a5uI:
undetectable		 3pp1A-5a5uI:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 ALA I 170
GLY I 171
GLY I 120
ASN I 114
HIS I 150
 None
 1.26A 4e47A-5a5uI:
undetectable		 4e47A-5a5uI:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 ALA I 170
GLY I 171
GLY I 120
ASN I 114
HIS I 150
 None
 1.25A 4e47B-5a5uI:
undetectable		 4e47B-5a5uI:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 ALA I 170
GLY I 171
GLY I 120
ASN I 114
HIS I 150
 None
 1.27A 4e47C-5a5uI:
undetectable		 4e47C-5a5uI:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 12 GLY I 311
GLY I 312
GLY I 315
LEU I   6
ALA I 309
 None
 0.99A 4htfB-5a5uI:
undetectable		 4htfB-5a5uI:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 ALA I 170
GLY I 171
GLY I 120
ASN I 114
HIS I 150
 None
 1.22A 4jdsA-5a5uI:
undetectable		 4jdsA-5a5uI:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 ALA I 170
GLY I 171
GLY I 120
ASN I 114
HIS I 150
 None
 1.21A 4jdsB-5a5uI:
undetectable		 4jdsB-5a5uI:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 ALA I 170
GLY I 171
GLY I 120
ASN I 114
HIS I 150
 None
 1.23A 4jdsC-5a5uI:
undetectable		 4jdsC-5a5uI:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 12 ALA I 170
GLY I 171
GLY I 120
ASN I 114
HIS I 150
 None
 1.22A 4jlgA-5a5uI:
2.1		 4jlgA-5a5uI:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 GLY I 255
GLY I 256
GLY I 257
ALA I 275
GLU I 274
 None
 1.01A 4l8fB-5a5uI:
undetectable		 4l8fB-5a5uI:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 GLY I 255
GLY I 256
GLY I 257
ALA I 275
GLU I 274
 None
 1.01A 4l8fD-5a5uI:
undetectable		 4l8fD-5a5uI:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 6 ASP I 201
ALA I 300
LYS I  17
THR I 298
 None
 1.48A 4w5tA-5a5uI:
undetectable		 4w5tA-5a5uI:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 6 ASP I 201
ALA I 300
LYS I  17
THR I 298
 None
 1.46A 4z4cA-5a5uI:
undetectable		 4z4cA-5a5uI:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 6 ASP I 201
ALA I 300
LYS I  17
THR I 298
 None
 1.43A 4z4iA-5a5uI:
undetectable		 4z4iA-5a5uI:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 5 ALA I 309
HIS I 279
PRO I 247
PHE I 277
 None
 1.38A 4ze2A-5a5uI:
undetectable		 4ze2A-5a5uI:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 11 ALA I 170
GLY I 171
GLY I 120
ASN I 114
HIS I 150
 None
 1.27A 5ayfA-5a5uI:
undetectable		 5ayfA-5a5uI:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 12 GLY I 311
THR I 298
ALA I 309
PHE I 277
LEU I 319
 None
 1.20A 5hw4A-5a5uI:
undetectable		 5hw4A-5a5uI:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 12 GLY I 311
THR I 298
ALA I 309
PHE I 277
LEU I 319
 None
 1.20A 5hw4C-5a5uI:
undetectable		 5hw4C-5a5uI:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 12 ALA I  88
PHE I 108
LEU I 136
GLY I  70
VAL I  99
 None
 1.36A 5i71A-5a5uI:
undetectable		 5i71A-5a5uI:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		5 / 12 GLY I 171
GLY I 175
SER I 215
ASP I 201
ALA I 155
 None
 1.17A 5kpcB-5a5uI:
undetectable		 5kpcB-5a5uI:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		3 / 3 THR I 213
HIS I 195
ASN I 219
 None
 0.94A 5n4tA-5a5uI:
undetectable		 5n4tA-5a5uI:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_2
(RIBOFLAVIN LYASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 4 ASN I  83
GLN I  85
ASP I  80
THR I 133
 None
 1.46A 5w4zB-5a5uI:
undetectable		 5w4zB-5a5uI:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I
(Oryctolagus
cuniculus) 		4 / 8 SER I 310
TYR I 308
HIS I 292
MET I   1
 None
 1.46A 5wqpA-5a5uI:
undetectable		 5wqpA-5a5uI:
20.99