SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 11 VAL A 221
TYR A 385
GLY A 224
HIS A 349
PHE A 268
 None
None
None
EDO  A2002 (-4.2A)
None
 1.43A 1iolA-5a60A:
undetectable		 1iolA-5a60A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 11 ALA A 294
THR A 306
VAL A 254
ALA A 250
THR A 299
 None
 0.94A 1jinA-5a60A:
undetectable		 1jinA-5a60A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 12 ALA A 294
THR A 306
VAL A 254
ALA A 250
THR A 299
 None
 0.95A 1jipA-5a60A:
undetectable		 1jipA-5a60A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		4 / 6 LEU A 161
LEU A   7
LEU A 184
LEU A 142
 None
 0.90A 2ab2A-5a60A:
undetectable		 2ab2A-5a60A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A 189
VAL A  74
TYR A 238
GLY A  76
GLU A 241
 None
 1.04A 3medA-5a60A:
1.5
3medB-5a60A:
undetectable		 3medA-5a60A:
20.42
3medB-5a60A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		3 / 3 ALA A  87
VAL A  86
GLN A  97
 None
 0.68A 3of4B-5a60A:
undetectable		 3of4B-5a60A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 5 GLU A   6
ARG A  58
LYS A  69
ARG A 126
GLU A 160
 MG  A 501 (-2.6A)
3PO  A1000 (-2.9A)
3PO  A1000 (-2.8A)
3PO  A1000 (-2.8A)
MG  A 500 ( 2.0A)
 0.89A 3tj7C-5a60A:
15.6		 3tj7C-5a60A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		4 / 5 GLU A 162
ARG A  58
LYS A  69
ARG A 126
 MG  A 501 (-3.0A)
3PO  A1000 (-2.9A)
3PO  A1000 (-2.8A)
3PO  A1000 (-2.8A)
 1.17A 3tj7C-5a60A:
15.6		 3tj7C-5a60A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		4 / 6 ARG A  58
GLU A 162
ARG A  81
GLU A   6
 3PO  A1000 (-2.9A)
MG  A 501 (-3.0A)
3PO  A1000 (-2.9A)
MG  A 501 (-2.6A)
 1.43A 4kr3A-5a60A:
undetectable		 4kr3A-5a60A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		4 / 6 GLU A   6
ARG A  81
GLU A 162
ARG A 126
 MG  A 501 (-2.6A)
3PO  A1000 (-2.9A)
MG  A 501 (-3.0A)
3PO  A1000 (-2.8A)
 1.45A 4kr3A-5a60A:
undetectable		 4kr3A-5a60A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		4 / 5 LYS A   8
GLU A 158
PHE A 124
VAL A 147
 3PO  A1000 (-2.8A)
None
3PO  A1000 (-4.8A)
None
 1.31A 4tvtA-5a60A:
undetectable		 4tvtA-5a60A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		4 / 5 LEU A 255
GLU A 240
LEU A 284
HIS A 263
 None
 0.98A 4xi3B-5a60A:
undetectable		 4xi3B-5a60A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 12 GLY A  76
ALA A 234
ALA A 257
ILE A 258
LEU A 311
 None
 1.22A 5bw4B-5a60A:
undetectable		 5bw4B-5a60A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 11 LEU A 178
ALA A 175
LEU A 311
GLY A  76
LEU A  78
 None
 1.20A 5dxgB-5a60A:
undetectable		 5dxgB-5a60A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 11 LEU A 178
ALA A 175
LEU A 311
HIS A  79
LEU A  78
 None
 1.44A 5hyrB-5a60A:
undetectable		 5hyrB-5a60A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 12 MET A  68
ALA A 192
VAL A 102
LEU A 112
VAL A 116
 None
 1.19A 5tudD-5a60A:
undetectable		 5tudD-5a60A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A  23
ASN A  24
LEU A  26
GLY A  28
LEU A 161
 None
 1.14A 5uc1B-5a60A:
undetectable		 5uc1B-5a60A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 12 GLY A 400
GLN A 399
LEU A 369
ILE A 413
LEU A 380
 None
 1.20A 5y2tA-5a60A:
undetectable		 5y2tA-5a60A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A 313
HIS A 263
THR A 373
LEU A 225
ALA A 228
 None
 1.20A 6djzA-5a60A:
undetectable		 6djzA-5a60A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 5a60 INORGANIC
TRIPHOSPHATASE
(Escherichia
coli) 		4 / 8 ALA A 264
GLY A 259
LEU A 260
ALA A 232
 None
 0.76A 6mdqA-5a60A:
3.2		 6mdqA-5a60A:
11.40