SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 11 GLY A 101
HIS A  98
HIS A  61
ILE A 103
GLY A  33
 None
 1.11A 1c9sP-5a62A:
undetectable
1c9sQ-5a62A:
undetectable		 1c9sP-5a62A:
17.15
1c9sQ-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 11 ILE A 120
ALA A 118
ILE A 268
PHE A 265
THR A  94
 None
 0.88A 1dyrA-5a62A:
undetectable		 1dyrA-5a62A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 1gtfJ-5a62A:
undetectable
1gtfK-5a62A:
undetectable		 1gtfJ-5a62A:
17.15
1gtfK-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 11 GLY A 101
HIS A  98
HIS A  61
ILE A 103
GLY A  33
 None
 1.13A 1gtfQ-5a62A:
undetectable
1gtfR-5a62A:
undetectable		 1gtfQ-5a62A:
17.15
1gtfR-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 11 GLY A 101
HIS A  98
HIS A  61
ILE A 103
GLY A  33
 None
 1.12A 1gtfS-5a62A:
undetectable
1gtfT-5a62A:
undetectable		 1gtfS-5a62A:
17.15
1gtfT-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 11 GLY A 101
HIS A  98
HIS A  61
ILE A 103
GLY A  33
 None
 1.11A 1gtnT-5a62A:
undetectable
1gtnU-5a62A:
undetectable		 1gtnT-5a62A:
17.15
1gtnU-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		4 / 6 PHE A 265
GLU A 239
LEU A 240
VAL A 217
 None
 0.96A 1hk1A-5a62A:
undetectable		 1hk1A-5a62A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		4 / 7 PHE A 265
GLU A 239
LEU A 240
VAL A 217
 None
 0.96A 1hk3A-5a62A:
undetectable		 1hk3A-5a62A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A 101
HIS A  98
HIS A  61
ILE A 103
GLY A  33
 None
 1.09A 1utdE-5a62A:
undetectable
1utdF-5a62A:
undetectable		 1utdE-5a62A:
17.15
1utdF-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A 101
HIS A  98
HIS A  61
ILE A 103
GLY A  33
 None
 1.08A 1utdH-5a62A:
undetectable
1utdI-5a62A:
undetectable		 1utdH-5a62A:
17.15
1utdI-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 11 GLY A 101
HIS A  98
HIS A  61
ILE A 103
GLY A  33
 None
 1.08A 1utdS-5a62A:
undetectable
1utdT-5a62A:
undetectable		 1utdS-5a62A:
17.15
1utdT-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 11 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.13A 1utdL-5a62A:
undetectable
1utdV-5a62A:
undetectable		 1utdL-5a62A:
17.15
1utdV-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ILE A 268
THR A  94
LEU A  26
PHE A  51
LEU A  46
 None
 1.50A 2mjiA-5a62A:
undetectable		 2mjiA-5a62A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 241
ILE A 103
GLY A 101
GLY A  97
ILE A  96
 None
 1.00A 2o4kA-5a62A:
undetectable		 2o4kA-5a62A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		4 / 8 SER A   8
THR A  13
LEU A  88
THR A  69
 None
 1.12A 2v0zO-5a62A:
undetectable		 2v0zO-5a62A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		4 / 5 ILE A  32
ARG A  59
MET A  74
THR A  73
 ACT  A 484 (-3.8A)
None
None
None
 1.03A 3abkN-5a62A:
undetectable
3abkW-5a62A:
undetectable		 3abkN-5a62A:
19.92
3abkW-5a62A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLU A 239
ILE A 261
GLY A 264
LEU A  46
ILE A 120
 None
 1.41A 3adsA-5a62A:
undetectable		 3adsA-5a62A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 GLY A  33
GLY A  34
VAL A 179
LEU A 152
ILE A 252
 None
 1.11A 3h52B-5a62A:
undetectable		 3h52B-5a62A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.93A 3nt1A-5a62A:
undetectable		 3nt1A-5a62A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.93A 3nt1B-5a62A:
undetectable		 3nt1B-5a62A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.86A 3pghD-5a62A:
undetectable		 3pghD-5a62A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.94A 3rr3A-5a62A:
undetectable		 3rr3A-5a62A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.93A 3rr3B-5a62A:
undetectable		 3rr3B-5a62A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.94A 3rr3C-5a62A:
undetectable		 3rr3C-5a62A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.94A 3rr3D-5a62A:
undetectable		 3rr3D-5a62A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		4 / 6 TYR A 196
ARG A 141
ASP A 133
GLN A 130
 None
 1.23A 4azvA-5a62A:
2.6		 4azvA-5a62A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 GLY A 102
GLY A 124
ILE A 100
ILE A  29
SER A 106
 None
None
ACT  A 484 (-3.8A)
None
None
 1.15A 4iv0B-5a62A:
undetectable		 4iv0B-5a62A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 VAL A 250
GLY A  97
ILE A 119
ILE A 104
SER A 106
 None
 1.20A 4xudA-5a62A:
3.1		 4xudA-5a62A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		4 / 7 MET A 258
HIS A 248
GLY A 124
ASN A 123
 None
ACT  A 484 ( 4.8A)
None
None
 1.29A 5a5zC-5a62A:
undetectable		 5a5zC-5a62A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5eevA-5a62A:
undetectable
5eevB-5a62A:
undetectable		 5eevA-5a62A:
17.15
5eevB-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5eewA-5a62A:
undetectable
5eewB-5a62A:
undetectable		 5eewA-5a62A:
17.15
5eewB-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5eexA-5a62A:
undetectable
5eexB-5a62A:
undetectable		 5eexA-5a62A:
17.15
5eexB-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5eeyA-5a62A:
undetectable
5eeyB-5a62A:
undetectable		 5eeyA-5a62A:
17.15
5eeyB-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5eezA-5a62A:
undetectable
5eezB-5a62A:
undetectable		 5eezA-5a62A:
17.15
5eezB-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5ef0A-5a62A:
undetectable
5ef0B-5a62A:
undetectable		 5ef0A-5a62A:
17.15
5ef0B-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5ef1A-5a62A:
undetectable
5ef1B-5a62A:
undetectable		 5ef1A-5a62A:
17.15
5ef1B-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5ef2A-5a62A:
undetectable
5ef2B-5a62A:
undetectable		 5ef2A-5a62A:
17.15
5ef2B-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 GLY A  33
GLY A 101
HIS A  98
HIS A  61
ILE A 103
 None
 1.08A 5ef3A-5a62A:
undetectable
5ef3B-5a62A:
undetectable		 5ef3A-5a62A:
17.15
5ef3B-5a62A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		4 / 8 LEU A  85
PRO A  25
ILE A  54
LEU A  84
 None
 0.80A 5g48A-5a62A:
undetectable		 5g48A-5a62A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.95A 5ikqA-5a62A:
undetectable		 5ikqA-5a62A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.94A 5ikqB-5a62A:
undetectable		 5ikqB-5a62A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.98A 5ikrA-5a62A:
undetectable		 5ikrA-5a62A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 1.01A 5ikrB-5a62A:
undetectable		 5ikrB-5a62A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 12 ARG A 207
VAL A 213
VAL A 203
GLY A 205
SER A 209
 None
 0.98A 5jvzA-5a62A:
undetectable		 5jvzA-5a62A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 9 VAL A 251
ILE A 122
GLY A  97
ILE A  29
ILE A  38
 None
 1.08A 5kqxB-5a62A:
undetectable		 5kqxB-5a62A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		3 / 3 THR A 231
SER A 125
ASP A 133
 None
 0.64A 5kvaA-5a62A:
undetectable		 5kvaA-5a62A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		3 / 3 THR A 231
SER A 125
ASP A 133
 None
 0.63A 5kvaB-5a62A:
undetectable		 5kvaB-5a62A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 TYR A 196
MET A  74
ILE A 103
ILE A 100
ILE A 104
 None
None
None
ACT  A 484 (-3.8A)
None
 1.06A 5murE-5a62A:
undetectable		 5murE-5a62A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN
(Candidatus
Nitrososphaera
gargensis) 		5 / 10 LEU A  28
HIS A  30
ILE A  96
GLY A  97
GLY A 101
 None
 0.90A 5o96C-5a62A:
2.2
5o96D-5a62A:
2.3		 5o96C-5a62A:
21.33
5o96D-5a62A:
21.33