SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5a65 THIAMINE
TRIPHOSPHATASE
(Mus
musculus) 		5 / 12 SER A 127
GLY A 156
ALA A 190
ASP A 147
ARG A 125
 None
None
None
None
PO4  A1001 (-3.0A)
 1.36A 2avdB-5a65A:
undetectable		 2avdB-5a65A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 5a65 THIAMINE
TRIPHOSPHATASE
(Mus
musculus) 		5 / 12 TYR A  39
PHE A 121
ALA A 149
ARG A 125
PHE A  35
 None
None
None
PO4  A1001 (-3.0A)
None
 1.20A 2noaA-5a65A:
undetectable		 2noaA-5a65A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5a65 THIAMINE
TRIPHOSPHATASE
(Mus
musculus) 		5 / 12 ALA A  87
LEU A  64
SER A  50
LEU A  47
LEU A  92
 None
 1.16A 3k2hA-5a65A:
undetectable		 3k2hA-5a65A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 5a65 THIAMINE
TRIPHOSPHATASE
(Mus
musculus) 		4 / 8 TYR A  39
PHE A 121
ARG A 125
PHE A  35
 None
None
PO4  A1001 (-3.0A)
None
 0.84A 3mjrD-5a65A:
undetectable		 3mjrD-5a65A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 5a65 THIAMINE
TRIPHOSPHATASE
(Mus
musculus) 		4 / 5 GLU A 157
ARG A  55
LYS A 193
GLU A 159
 MG  A 500 (-2.7A)
TPP  A1000 (-3.2A)
TPP  A1000 (-2.8A)
MG  A 501 (-1.9A)
 1.11A 3tj7C-5a65A:
11.1		 3tj7C-5a65A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 5a65 THIAMINE
TRIPHOSPHATASE
(Mus
musculus) 		4 / 5 GLU A 157
ARG A  57
LYS A 193
GLU A 159
 MG  A 500 (-2.7A)
TPP  A1000 ( 3.2A)
TPP  A1000 (-2.8A)
MG  A 501 (-1.9A)
 1.10A 3tj7C-5a65A:
11.1		 3tj7C-5a65A:
26.11