SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		4 / 6 THR A 204
LEU A 201
GLY A 199
TYR A 178
 None
 1.10A 1gtiC-5a6cA:
undetectable		 1gtiC-5a6cA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		4 / 5 ASP A  81
SER A  55
LEU A  92
GLY A  93
 None
 0.97A 2j2pA-5a6cA:
undetectable
2j2pB-5a6cA:
undetectable		 2j2pA-5a6cA:
22.87
2j2pB-5a6cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		4 / 6 ASP A  81
SER A  55
LEU A  92
GLY A  93
 None
 1.00A 2j2pA-5a6cA:
undetectable
2j2pC-5a6cA:
undetectable		 2j2pA-5a6cA:
22.87
2j2pC-5a6cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		4 / 6 ASP A  81
SER A  55
LEU A  92
GLY A  93
 None
 0.98A 2j2pD-5a6cA:
undetectable
2j2pF-5a6cA:
undetectable		 2j2pD-5a6cA:
22.87
2j2pF-5a6cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		5 / 12 LEU A 287
THR A 286
PHE A 372
SER A 320
HIS A 298
 None
 0.97A 2ydoA-5a6cA:
undetectable		 2ydoA-5a6cA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		4 / 7 TYR A 375
ARG A 316
HIS A 301
ALA A 275
 None
 1.44A 3frqB-5a6cA:
undetectable		 3frqB-5a6cA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		4 / 6 GLY A 202
THR A 204
LEU A 208
ASP A 213
 None
 0.99A 3ps9A-5a6cA:
undetectable		 3ps9A-5a6cA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		3 / 3 GLY A 102
THR A 104
ASN A 100
 None
 0.70A 3v4tD-5a6cA:
undetectable		 3v4tD-5a6cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		4 / 5 ALA A 225
ARG A 236
ALA A 192
GLU A 377
 None
 1.46A 5a06C-5a6cA:
undetectable
5a06D-5a6cA:
undetectable		 5a06C-5a6cA:
22.62
5a06D-5a6cA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		5 / 9 ASP A 213
LEU A 201
GLY A 202
LEU A 171
GLU A 179
 None
 1.20A 5dqfA-5a6cA:
undetectable		 5dqfA-5a6cA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		3 / 3 GLY A  31
CYH A  33
CYH A  28
 None
 0.97A 5inzB-5a6cA:
undetectable		 5inzB-5a6cA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens) 		4 / 7 LEU A  68
ASP A  70
ALA A  72
LEU A  75
 None
 0.91A 5nwvA-5a6cA:
undetectable		 5nwvA-5a6cA:
7.12