SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 12 LEU A  53
VAL A  36
ILE A   5
LEU A 115
LEU A  99
None
1.12A 1s19A-5a6dA:
undetectable
1s19A-5a6dA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 12 LEU A 243
SER A  44
ALA A 244
LEU A  23
ARG A 246
None
1.23A 2japB-5a6dA:
undetectable
2japB-5a6dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 12 LEU A 243
SER A  44
ALA A 244
LEU A  23
ARG A 246
None
1.27A 2japD-5a6dA:
undetectable
2japD-5a6dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
4 / 8 ILE A 145
TYR A 199
LEU A 219
VAL A 134
None
0.90A 2w98B-5a6dA:
undetectable
2w98B-5a6dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 12 ILE A 145
ALA A 205
VAL A  47
LEU A 242
LEU A 227
None
1.15A 3s79A-5a6dA:
undetectable
3s79A-5a6dA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
4 / 6 MET A  41
LEU A  48
PRO A 126
PRO A 226
None
0.92A 3vkxA-5a6dA:
31.0
3vkxA-5a6dA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 12 ILE A 101
THR A 102
ILE A   5
GLU A  62
GLU A  64
None
1.30A 4i41A-5a6dA:
undetectable
4i41A-5a6dA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
3 / 3 ARG A  82
LYS A  78
LYS A  81
None
1.30A 4k50I-5a6dA:
undetectable
4k50I-5a6dA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 10 LEU A 155
VAL A 140
LEU A 136
LEU A 179
VAL A 134
None
1.08A 4po0A-5a6dA:
undetectable
4po0A-5a6dA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 12 ILE A 145
ALA A 205
VAL A  47
LEU A 242
LEU A 227
None
1.13A 5jkvA-5a6dA:
undetectable
5jkvA-5a6dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
4 / 8 LEU A 179
ILE A 177
PHE A 164
ALA A 144
None
0.72A 5m0oC-5a6dA:
undetectable
5m0oC-5a6dA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 10 ASP A 215
GLY A 212
ASP A  50
THR A 240
THR A  19
None
0.83A 6mn1A-5a6dA:
undetectable
6mn1A-5a6dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans)
5 / 10 ASP A 215
GLY A 212
ASP A  50
THR A 240
THR A  19
None
0.87A 6mn1B-5a6dA:
undetectable
6mn1B-5a6dA:
18.22