SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 TYR C 467
ASP C 483
PHE C 956
VAL C 353
PHE C 433
 None
 1.09A 1c9hA-5a6fC:
undetectable		 1c9hA-5a6fC:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		3 / 3 THR C 974
THR C 973
PRO C 975
 None
 0.86A 1i3wF-5a6fC:
undetectable		 1i3wF-5a6fC:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 LEU C 496
SER C 946
GLN C 469
THR C 950
 None
 1.14A 1ig3A-5a6fC:
3.1
1ig3B-5a6fC:
4.1		 1ig3A-5a6fC:
15.76
1ig3B-5a6fC:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		3 / 3 THR C 973
PRO C 975
THR C 974
 None
 0.84A 1mnvD-5a6fC:
undetectable		 1mnvD-5a6fC:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 5 VAL C 357
SER C 359
ASP C 447
GLN C 469
 None
 1.44A 1n2xB-5a6fC:
6.5		 1n2xB-5a6fC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		3 / 3 THR C 974
THR C 973
PRO C 975
 None
 0.85A 1qfiA-5a6fC:
undetectable		 1qfiA-5a6fC:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		3 / 3 THR C 973
PRO C 975
THR C 974
 None
 0.85A 1unjF-5a6fC:
undetectable		 1unjF-5a6fC:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		3 / 3 THR C 974
THR C 973
PRO C 975
 None
 0.82A 1unjF-5a6fC:
undetectable		 1unjF-5a6fC:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 11 TYR C 467
ASP C 483
PHE C 956
VAL C 353
PHE C 433
 None
 1.12A 2dg4A-5a6fC:
undetectable		 2dg4A-5a6fC:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 11 LEU C 512
LEU C 508
ILE C 575
ASN C 588
LEU C 951
 None
 1.15A 2ft9A-5a6fC:
undetectable		 2ft9A-5a6fC:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 7 LEU C 809
ILE C 891
SER C 889
TYR C 493
 None
 1.14A 2hc4A-5a6fC:
undetectable		 2hc4A-5a6fC:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 6 HIS C 593
PHE C 559
ARG C 578
GLY C 576
 None
 1.05A 2i30A-5a6fC:
undetectable		 2i30A-5a6fC:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 ALA C 431
VAL C 353
LEU C 378
HIS C 375
 None
 0.91A 2it4A-5a6fC:
undetectable		 2it4A-5a6fC:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 5 LEU C 587
GLY C 576
ILE C1009
ILE C1165
 None
 0.69A 2q9rA-5a6fC:
undetectable		 2q9rA-5a6fC:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 LEU C 809
LEU C 811
ALA C 780
VAL C 856
LEU C 948
 None
 1.19A 3b0wA-5a6fC:
undetectable		 3b0wA-5a6fC:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 11 TYR C 532
GLN C 529
TYR C 995
ILE C1013
PRO C 503
 None
 1.47A 3ganA-5a6fC:
undetectable		 3ganA-5a6fC:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 TYR C 788
GLY C 786
PHE C 790
PHE C 826
CYH C 825
 None
 1.46A 3s8pA-5a6fC:
undetectable		 3s8pA-5a6fC:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 TYR C 788
GLY C 786
PHE C 790
PHE C 826
CYH C 825
 None
 1.45A 3s8pB-5a6fC:
undetectable		 3s8pB-5a6fC:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		3 / 3 TYR C 868
MET C 391
LEU C 365
 None
 0.88A 3vw1D-5a6fC:
undetectable		 3vw1D-5a6fC:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 TYR C 788
GLY C 786
PHE C 790
PHE C 826
CYH C 825
 None
 1.46A 4bupB-5a6fC:
undetectable		 4bupB-5a6fC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		3 / 3 ASP C 871
ARG C 923
ARG C 934
 None
 0.87A 4x5iA-5a6fC:
0.7		 4x5iA-5a6fC:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 7 SER C 536
TYR C 532
PHE C 933
GLU C 520
 None
 1.26A 4xzkA-5a6fC:
undetectable		 4xzkA-5a6fC:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 TYR C 995
GLY C 996
LEU C 574
PHE C 559
GLY C 590
 None
 1.28A 4ze1A-5a6fC:
undetectable		 4ze1A-5a6fC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 TYR C 788
GLY C 786
PHE C 790
PHE C 826
CYH C 825
 None
 1.50A 5cprB-5a6fC:
undetectable		 5cprB-5a6fC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 TYR C 467
ASP C 483
PHE C 956
VAL C 353
PHE C 433
 None
 1.06A 5hkgA-5a6fC:
undetectable		 5hkgA-5a6fC:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 5 ASN C 838
ASP C 837
ASN C 877
ASP C 857
 None
 1.34A 5vooE-5a6fC:
undetectable		 5vooE-5a6fC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 TYR C 788
GLY C 786
PHE C 790
PHE C 826
CYH C 825
 None
 1.47A 5wbvA-5a6fC:
undetectable		 5wbvA-5a6fC:
17.49