SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		3 / 3 LEU A  10
SER A 173
ASN A  13
 None
 0.77A 1bx4A-5a6sA:
undetectable		 1bx4A-5a6sA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 9 ASN A 224
LEU A 250
VAL A 239
GLY A 240
ALA A 210
 None
 1.29A 1e7aA-5a6sA:
undetectable		 1e7aA-5a6sA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 11 TYR A 121
PHE A  61
VAL A  90
TYR A  59
GLU A 165
 SO4  A1274 (-4.4A)
None
None
SO4  A1274 (-4.5A)
None
 1.49A 2fl5A-5a6sA:
undetectable
2fl5B-5a6sA:
undetectable
2fl5F-5a6sA:
undetectable		 2fl5A-5a6sA:
20.74
2fl5B-5a6sA:
19.62
2fl5F-5a6sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 10 LYS A 190
ILE A 186
ILE A  55
LYS A   2
ILE A  25
 None
 1.40A 2j9dD-5a6sA:
0.5
2j9dE-5a6sA:
undetectable
2j9dF-5a6sA:
undetectable		 2j9dD-5a6sA:
17.45
2j9dE-5a6sA:
16.55
2j9dF-5a6sA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 9 ILE A  55
LYS A   2
ILE A  25
LYS A 190
ILE A 186
 None
 1.44A 2j9dG-5a6sA:
0.6
2j9dH-5a6sA:
undetectable
2j9dI-5a6sA:
undetectable		 2j9dG-5a6sA:
17.45
2j9dH-5a6sA:
17.45
2j9dI-5a6sA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 9 LYS A   2
ILE A  25
LYS A 190
ILE A 186
ILE A  55
 None
 1.38A 2j9dG-5a6sA:
0.6
2j9dH-5a6sA:
undetectable
2j9dI-5a6sA:
undetectable		 2j9dG-5a6sA:
17.45
2j9dH-5a6sA:
17.45
2j9dI-5a6sA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		4 / 5 VAL A  90
TYR A  59
ASP A 177
SER A 179
 None
SO4  A1274 (-4.5A)
SO4  A1274 (-3.4A)
None
 0.66A 2x45A-5a6sA:
undetectable		 2x45A-5a6sA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		4 / 5 VAL A  90
TYR A  59
ASP A 177
SER A 179
 None
SO4  A1274 (-4.5A)
SO4  A1274 (-3.4A)
None
 0.62A 2x45C-5a6sA:
undetectable		 2x45C-5a6sA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 10 GLY A  57
PHE A  88
GLY A  26
THR A  49
ILE A  55
 None
 1.42A 2y7wB-5a6sA:
undetectable		 2y7wB-5a6sA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 9 ASP A   6
ILE A 181
ILE A 142
VAL A  90
ILE A  28
 SO4  A1274 (-4.0A)
None
None
None
None
 1.12A 3ekyB-5a6sA:
undetectable		 3ekyB-5a6sA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 11 ASP A   6
ILE A 181
ILE A 142
VAL A  90
ILE A  28
 SO4  A1274 (-4.0A)
None
None
None
None
 0.99A 3lzvB-5a6sA:
undetectable		 3lzvB-5a6sA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 10 ASP A   6
ILE A 181
ILE A 142
VAL A  90
ILE A  28
 SO4  A1274 (-4.0A)
None
None
None
None
 0.96A 3nu6A-5a6sA:
undetectable		 3nu6A-5a6sA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 10 ASP A   6
ILE A 181
ILE A 142
VAL A  90
ILE A  28
 SO4  A1274 (-4.0A)
None
None
None
None
 0.97A 3nujA-5a6sA:
undetectable		 3nujA-5a6sA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 9 ASP A   6
ILE A 181
ILE A 142
VAL A  90
ILE A  28
 SO4  A1274 (-4.0A)
None
None
None
None
 0.95A 3nuoA-5a6sA:
undetectable		 3nuoA-5a6sA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		4 / 5 TYR A 145
ASN A 144
GLU A  94
TYR A 121
 None
None
SO4  A1274 (-3.0A)
SO4  A1274 (-4.4A)
 1.39A 4twdC-5a6sA:
undetectable
4twdD-5a6sA:
undetectable		 4twdC-5a6sA:
20.62
4twdD-5a6sA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		4 / 6 TYR A 145
ASN A 144
GLU A  94
TYR A 121
 None
None
SO4  A1274 (-3.0A)
SO4  A1274 (-4.4A)
 1.39A 4twdG-5a6sA:
undetectable
4twdH-5a6sA:
undetectable		 4twdG-5a6sA:
20.62
4twdH-5a6sA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		3 / 3 TYR A 249
THR A 251
THR A 247
 None
 0.78A 5aoxB-5a6sA:
undetectable		 5aoxB-5a6sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		3 / 3 TYR A 249
THR A 251
THR A 247
 None
 0.83A 5aoxE-5a6sA:
undetectable		 5aoxE-5a6sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		5 / 10 TRP A 141
GLY A  26
VAL A  90
MET A 160
PHE A 185
 None
 1.33A 5g6sD-5a6sA:
2.3
5g6sF-5a6sA:
2.5		 5g6sD-5a6sA:
22.03
5g6sF-5a6sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		3 / 3 SER A 231
TYR A 230
TYR A 249
 None
 0.91A 5lakC-5a6sA:
undetectable
5lakJ-5a6sA:
undetectable		 5lakC-5a6sA:
21.89
5lakJ-5a6sA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5a6s ENDOLYSIN
(Clostridium
phage
phiCTP1) 		4 / 7 ASP A 177
TYR A 121
GLU A  94
GLU A  33
 SO4  A1274 (-3.4A)
SO4  A1274 (-4.4A)
SO4  A1274 (-3.0A)
None
 1.16A 6mn5E-5a6sA:
undetectable		 6mn5E-5a6sA:
15.00