SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ALA A 578
VAL A 529
TRP A 501
 None
 0.75A 1av2A-5a7mA:
undetectable
1av2B-5a7mA:
undetectable		 1av2A-5a7mA:
1.95
1av2B-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ALA A 382
VAL A 377
TRP A 374
 NAG  A1501 (-4.1A)
None
None
 0.70A 1av2C-5a7mA:
undetectable
1av2D-5a7mA:
undetectable		 1av2C-5a7mA:
1.95
1av2D-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TRP A 501
ALA A 578
VAL A 529
 None
 0.54A 1av2C-5a7mA:
undetectable
1av2D-5a7mA:
undetectable		 1av2C-5a7mA:
1.95
1av2D-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_2
(DIHYDROFOLATE
REDUCTASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 4 TYR A 429
ARG A 221
VAL A 205
THR A 170
 ACT  A1923 ( 4.2A)
TRS  A1920 (-2.9A)
None
None
 1.42A 1dlsA-5a7mA:
0.0		 1dlsA-5a7mA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 VAL A 295
VAL A 288
ASP A 321
ILE A 322
 None
 1.01A 1p7rA-5a7mA:
undetectable		 1p7rA-5a7mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ALA A 578
VAL A 529
TRP A 501
 None
 0.73A 1w5uA-5a7mA:
undetectable
1w5uB-5a7mA:
undetectable		 1w5uA-5a7mA:
1.95
1w5uB-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TRP A 501
ALA A 578
VAL A 529
 None
 0.63A 1w5uA-5a7mA:
undetectable
1w5uB-5a7mA:
undetectable		 1w5uA-5a7mA:
1.95
1w5uB-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ALA A 382
VAL A 377
TRP A 374
 NAG  A1501 (-4.1A)
None
None
 0.70A 1w5uC-5a7mA:
undetectable
1w5uD-5a7mA:
undetectable		 1w5uC-5a7mA:
1.95
1w5uD-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 TYR A 147
PHE A 112
ALA A 153
ILE A 130
ILE A 133
 None
 1.30A 2bjfA-5a7mA:
undetectable		 2bjfA-5a7mA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 ASN A 155
VAL A 156
ILE A 190
SER A 250
ASP A  95
 None
None
None
None
ZN  A1903 ( 2.1A)
 1.35A 2iyfB-5a7mA:
4.4		 2iyfB-5a7mA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ALA A 578
VAL A 529
TRP A 501
 None
 0.49A 2izqA-5a7mA:
undetectable
2izqB-5a7mA:
undetectable		 2izqA-5a7mA:
1.95
2izqB-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TRP A 374
ALA A 382
VAL A 377
 None
NAG  A1501 (-4.1A)
None
 0.84A 2izqA-5a7mA:
undetectable
2izqB-5a7mA:
undetectable		 2izqA-5a7mA:
1.95
2izqB-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TRP A 501
ALA A 578
VAL A 529
 None
 0.80A 2izqC-5a7mA:
undetectable
2izqD-5a7mA:
undetectable		 2izqC-5a7mA:
1.95
2izqD-5a7mA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 7 LEU A 233
PHE A 241
PHE A 271
ILE A 228
ASN A 258
 None
 0.98A 2opxA-5a7mA:
3.3		 2opxA-5a7mA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 GLY A 158
GLN A 240
PHE A 241
PHE A 208
 None
 1.21A 2qx4A-5a7mA:
5.7
2qx4B-5a7mA:
5.8		 2qx4A-5a7mA:
15.17
2qx4B-5a7mA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 GLY A 158
THR A 170
GLN A 240
PHE A 241
 None
 1.21A 2qx4A-5a7mA:
5.7
2qx4B-5a7mA:
5.8		 2qx4A-5a7mA:
15.17
2qx4B-5a7mA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 TYR A 674
LEU A 627
ALA A 662
PHE A 660
 None
 0.88A 2vcvA-5a7mA:
undetectable		 2vcvA-5a7mA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 6 TYR A 211
ILE A 116
ASN A 155
LEU A  91
 None
 1.33A 2wekB-5a7mA:
3.2		 2wekB-5a7mA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 5 ALA A 494
ASP A 495
GLU A 214
TRP A 164
 None
 1.30A 2xrzA-5a7mA:
undetectable		 2xrzA-5a7mA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 10 THR A 183
SER A 180
VAL A 156
VAL A 205
LEU A 253
 None
 1.23A 3casA-5a7mA:
3.4		 3casA-5a7mA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 10 ILE A 485
GLY A 484
GLY A 483
LEU A 482
PRO A 549
 None
 1.00A 3em4V-5a7mA:
undetectable		 3em4V-5a7mA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 6 TYR A 369
GLY A 189
THR A 136
GLU A 185
 None
 1.04A 3fpjA-5a7mA:
2.9		 3fpjA-5a7mA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 5 PRO A 404
SER A 406
LEU A 396
SER A 542
 None
 1.24A 3ijxH-5a7mA:
undetectable		 3ijxH-5a7mA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 5 PRO A 404
SER A 406
LEU A 396
SER A 542
 None
 1.29A 3iluH-5a7mA:
undetectable		 3iluH-5a7mA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 SER A 179
PRO A 239
GLY A 210
ARG A 160
GLU A 214
 None
 1.43A 3jb2A-5a7mA:
undetectable		 3jb2A-5a7mA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ALA A 382
VAL A 377
TRP A 374
 NAG  A1501 (-4.1A)
None
None
 0.80A 3l8lA-5a7mA:
undetectable
3l8lB-5a7mA:
undetectable		 3l8lA-5a7mA:
1.95
3l8lB-5a7mA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TRP A 501
ALA A 578
VAL A 529
 None
 0.73A 3l8lA-5a7mA:
undetectable
3l8lB-5a7mA:
undetectable		 3l8lA-5a7mA:
1.95
3l8lB-5a7mA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ALA A 382
VAL A 377
TRP A 374
 NAG  A1501 (-4.1A)
None
None
 0.77A 3l8lC-5a7mA:
undetectable
3l8lD-5a7mA:
undetectable		 3l8lC-5a7mA:
1.95
3l8lD-5a7mA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TRP A 501
ALA A 578
VAL A 529
 None
 0.79A 3l8lC-5a7mA:
undetectable
3l8lD-5a7mA:
undetectable		 3l8lC-5a7mA:
1.95
3l8lD-5a7mA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 9 PRO A 154
TYR A 186
ILE A 190
ILE A 187
VAL A 151
 None
 1.32A 3p4wA-5a7mA:
undetectable		 3p4wA-5a7mA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 ASP A 293
ALA A 294
ASP A 323
TYR A 152
 None
None
None
GOL  A1922 (-4.6A)
 1.18A 3rodD-5a7mA:
undetectable		 3rodD-5a7mA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 11 VAL A 572
VAL A 395
ALA A 390
LEU A 571
TYR A 182
 None
 1.02A 3sm2B-5a7mA:
undetectable		 3sm2B-5a7mA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 10 LEU A 353
VAL A  86
VAL A 205
THR A 204
PHE A 282
 None
 1.43A 3tbgC-5a7mA:
undetectable		 3tbgC-5a7mA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 9 ASP A 498
ALA A 500
ASP A 530
GLY A 484
ILE A 458
 None
 1.22A 3u7sB-5a7mA:
undetectable		 3u7sB-5a7mA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 ILE A 509
MET A 524
GLY A 484
ASP A 486
LEU A 557
 None
 1.19A 3v8vA-5a7mA:
2.7		 3v8vA-5a7mA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 8 ILE A 458
ILE A 489
VAL A 529
GLY A 527
 None
 0.81A 4acaC-5a7mA:
6.0		 4acaC-5a7mA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 LEU A 222
GLU A 214
GLU A 492
ARG A 166
TYR A 429
 None
None
TRS  A1920 (-2.9A)
GOL  A1922 (-2.8A)
ACT  A1923 ( 4.2A)
 1.08A 4cpzA-5a7mA:
undetectable		 4cpzA-5a7mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 LEU A 222
GLU A 214
GLU A 492
ARG A 166
TYR A 429
 None
None
TRS  A1920 (-2.9A)
GOL  A1922 (-2.8A)
ACT  A1923 ( 4.2A)
 1.05A 4cpzB-5a7mA:
undetectable		 4cpzB-5a7mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 LEU A 222
GLU A 214
GLU A 492
ARG A 166
TYR A 429
 None
None
TRS  A1920 (-2.9A)
GOL  A1922 (-2.8A)
ACT  A1923 ( 4.2A)
 1.07A 4cpzD-5a7mA:
undetectable		 4cpzD-5a7mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 LEU A 222
GLU A 214
GLU A 492
ARG A 166
TYR A 429
 None
None
TRS  A1920 (-2.9A)
GOL  A1922 (-2.8A)
ACT  A1923 ( 4.2A)
 1.06A 4cpzE-5a7mA:
undetectable		 4cpzE-5a7mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 PRO A 549
GLY A 553
GLY A 554
ASP A  95
GLY A 431
 None
None
None
ZN  A1903 ( 2.1A)
None
 0.84A 4fp9D-5a7mA:
undetectable		 4fp9D-5a7mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 PRO A 549
GLY A 553
GLY A 554
ASP A  95
GLY A 431
 None
None
None
ZN  A1903 ( 2.1A)
None
 0.84A 4fzvA-5a7mA:
undetectable		 4fzvA-5a7mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 10 ILE A 485
ALA A 500
ASP A 498
THR A 456
ILE A 458
 None
 1.21A 4km0A-5a7mA:
undetectable		 4km0A-5a7mA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_A_VIBA501_1
(THIAMINE
PYRIDINYLASE I)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 10 TYR A 211
TYR A 257
ASP A 291
TYR A 429
GLU A 169
 None
None
GOL  A1922 (-3.3A)
ACT  A1923 ( 4.2A)
None
 1.40A 4kysA-5a7mA:
0.0		 4kysA-5a7mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 SER A 290
ASP A 323
GLN A 326
 None
 0.92A 4oltA-5a7mA:
undetectable
4oltB-5a7mA:
undetectable		 4oltA-5a7mA:
15.58
4oltB-5a7mA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A 483
ASP A 486
ILE A 458
ALA A 459
GLN A 505
 None
 1.40A 4wh5A-5a7mA:
undetectable		 4wh5A-5a7mA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 4 ASN A 356
SER A 250
ALA A 202
VAL A 201
 None
 1.13A 4x1kC-5a7mA:
undetectable		 4x1kC-5a7mA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 6 ILE A 127
VAL A 572
PHE A 698
THR A 675
 None
 0.97A 4xe5A-5a7mA:
4.8		 4xe5A-5a7mA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 9 TYR A 603
THR A 574
THR A 119
LEU A 178
LEU A 695
 None
 1.22A 4ze0A-5a7mA:
undetectable		 4ze0A-5a7mA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ASP A  95
ARG A  96
TYR A 429
 ZN  A1903 ( 2.1A)
ACT  A1923 (-4.1A)
ACT  A1923 ( 4.2A)
 0.01A 5a7mA-5a7mA:
74.7		 5a7mA-5a7mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ASP A  95
ARG A  96
TYR A 429
 ZN  A1903 ( 2.1A)
ACT  A1923 (-4.1A)
ACT  A1923 ( 4.2A)
 0.04A 5a7mB-5a7mA:
66.6		 5a7mB-5a7mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 TRP A 605
THR A 602
TYR A 606
THR A 607
 None
 1.18A 5b6iA-5a7mA:
undetectable		 5b6iA-5a7mA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 6 TRP A 605
THR A 602
TYR A 606
THR A 607
 None
 1.19A 5b6iB-5a7mA:
undetectable		 5b6iB-5a7mA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A 554
ALA A 421
ILE A 480
LEU A 522
ALA A 390
 None
 1.25A 5bw4B-5a7mA:
2.0		 5bw4B-5a7mA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 LEU A 506
GLY A 483
PHE A 466
THR A 464
ASN A 504
 None
 1.14A 5d0yA-5a7mA:
undetectable		 5d0yA-5a7mA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 8 LEU A  59
GLU A 347
LEU A  65
LEU A  81
 None
 1.26A 5dxeA-5a7mA:
undetectable		 5dxeA-5a7mA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A 465
ILE A 437
GLY A 553
LEU A 414
THR A 456
 None
 1.04A 5eqbA-5a7mA:
undetectable		 5eqbA-5a7mA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 ASP A 381
SER A 552
TYR A 435
 NAG  A1501 ( 4.9A)
NAG  A1501 (-2.7A)
NAG  A1502 (-4.0A)
 0.82A 5glmA-5a7mA:
undetectable		 5glmA-5a7mA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 5 GLY A 172
PRO A 239
GLN A 240
THR A 170
 None
 1.21A 5h5fA-5a7mA:
undetectable		 5h5fA-5a7mA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 LYS A 564
GLN A 551
ASN A 384
 None
None
NAG  A1501 ( 1.9A)
 1.04A 5l2tA-5a7mA:
undetectable		 5l2tA-5a7mA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 12 ARG A 166
LYS A 206
HIS A 207
MET A 254
GLU A 492
 GOL  A1922 (-2.8A)
GOL  A1922 (-3.0A)
GOL  A1922 (-3.9A)
GOL  A1922 ( 3.7A)
TRS  A1920 (-2.9A)
 0.63A 5m6gA-5a7mA:
11.7		 5m6gA-5a7mA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TYR A 737
SER A 683
TRP A 694
 None
 0.84A 5n8jB-5a7mA:
undetectable		 5n8jB-5a7mA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TYR A 737
SER A 683
TRP A 694
 None
 0.81A 5n8jA-5a7mA:
undetectable		 5n8jA-5a7mA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		3 / 3 TYR A 737
SER A 683
TRP A 694
 None
 0.82A 5n8jD-5a7mA:
undetectable		 5n8jD-5a7mA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 8 TRP A 280
THR A 274
GLN A 230
TRP A 763
 None
ZN  A1909 ( 4.4A)
None
None
 1.29A 5tzoA-5a7mA:
undetectable		 5tzoA-5a7mA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 8 TRP A 280
THR A 274
GLN A 230
TRP A 763
 None
ZN  A1909 ( 4.4A)
None
None
 1.31A 5tzoC-5a7mA:
undetectable		 5tzoC-5a7mA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 LEU A 618
TYR A 674
GLU A 625
SER A 746
 None
 1.01A 5umwA-5a7mA:
undetectable
5umwF-5a7mA:
undetectable		 5umwA-5a7mA:
6.14
5umwF-5a7mA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 GLN A 368
GLY A 192
TYR A 147
ASP A 195
 None
 0.97A 5vlmE-5a7mA:
undetectable		 5vlmE-5a7mA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 6 TYR A 548
TRP A 418
LEU A 482
LEU A 557
 None
 1.18A 5xooA-5a7mA:
undetectable		 5xooA-5a7mA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 8 GLY A 325
GLN A 326
THR A 327
SER A 290
 None
 1.14A 6eqpA-5a7mA:
undetectable		 6eqpA-5a7mA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		5 / 10 ARG A 359
VAL A 358
LEU A 360
LEU A  81
VAL A  42
 None
 1.22A 6eu9B-5a7mA:
undetectable		 6eu9B-5a7mA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5a7m BETA-XYLOSIDASE
(Trichoderma
reesei) 		4 / 7 ALA A 459
GLY A 503
GLY A 416
TYR A 481
 None
 0.83A 6nm4A-5a7mA:
undetectable		 6nm4A-5a7mA:
13.25