SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 TRP A 393
TRP A 338
PHE A 391
GLU A 339
 None
 1.40A 1om5A-5a7xA:
undetectable
1om5B-5a7xA:
undetectable		 1om5A-5a7xA:
20.32
1om5B-5a7xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		5 / 11 GLY A 451
GLY A 263
GLU A 482
GLN A 287
ILE A 270
 None
None
None
None
NAG  A 789 (-3.3A)
 1.47A 2dr2A-5a7xA:
undetectable		 2dr2A-5a7xA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER A 365
ASP A 457
ASN A 280
 None
 0.95A 3lsfB-5a7xA:
undetectable
3lsfE-5a7xA:
undetectable		 3lsfB-5a7xA:
22.26
3lsfE-5a7xA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ASP A 457
ASN A 280
SER A 365
 None
 0.92A 3lsfB-5a7xA:
undetectable
3lsfE-5a7xA:
undetectable		 3lsfB-5a7xA:
22.26
3lsfE-5a7xA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
 None
 1.42A 4k39A-5a7xA:
undetectable		 4k39A-5a7xA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 LEU A 452
GLY A 471
GLN A 258
LEU A 390
ILE A 272
 None
 1.21A 4p6xA-5a7xA:
undetectable		 4p6xA-5a7xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 LEU A 452
GLY A 471
GLN A 258
LEU A 390
ILE A 272
 None
 1.20A 4p6xE-5a7xA:
undetectable		 4p6xE-5a7xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 GLN A 352
ILE A 345
LEU A 453
VAL A 286
ILE A 270
 NAG  A 734 (-4.6A)
None
None
None
NAG  A 789 (-3.3A)
 1.07A 4uw0A-5a7xA:
undetectable		 4uw0A-5a7xA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 TYR A 486
LYS A 485
LYS A 227
 None
 1.33A 5dbyA-5a7xA:
undetectable		 5dbyA-5a7xA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE A 468
LEU A 452
ARG A 469
GLY A 471
 None
 1.12A 5o4yA-5a7xA:
undetectable		 5o4yA-5a7xA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5a7x HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 HIS A 374
ASN A 377
VAL A 255
LEU A 260
 None
 1.26A 5xdhA-5a7xA:
undetectable
5xdhC-5a7xA:
undetectable		 5xdhA-5a7xA:
12.14
5xdhC-5a7xA:
12.14