SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  82
LEU A  42
SER A  17
ILE A  58
LEU A  28
 None
 1.02A 1ddrA-5a7yA:
undetectable		 1ddrA-5a7yA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  82
LEU A  42
SER A  17
ILE A  58
LEU A  28
 None
 1.23A 1rh3A-5a7yA:
undetectable		 1rh3A-5a7yA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 10 SER A  30
LEU A  31
SER A  27
LEU A  60
ASP A  55
 None
 1.26A 2j1gE-5a7yA:
undetectable
2j1gF-5a7yA:
undetectable		 2j1gE-5a7yA:
20.94
2j1gF-5a7yA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 9 SER A  30
LEU A  31
SER A  27
LEU A  60
ASP A  55
 None
 1.31A 2j2pB-5a7yA:
undetectable
2j2pC-5a7yA:
undetectable		 2j2pB-5a7yA:
20.94
2j2pC-5a7yA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 9 SER A  30
LEU A  31
SER A  27
LEU A  60
ASP A  55
 None
 1.35A 2j2pD-5a7yA:
undetectable
2j2pE-5a7yA:
undetectable		 2j2pD-5a7yA:
20.94
2j2pE-5a7yA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 10 ILE A  33
LEU A  37
ARG A 140
GLY A 139
ALA A 141
 None
 1.17A 2xf3A-5a7yA:
undetectable		 2xf3A-5a7yA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		4 / 7 THR A 129
VAL A 178
ASP A  93
VAL A  91
 None
 0.93A 4cp4A-5a7yA:
undetectable		 4cp4A-5a7yA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  82
LEU A  42
SER A  17
ILE A  58
LEU A  28
 None
 1.13A 4qi9A-5a7yA:
undetectable		 4qi9A-5a7yA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  82
LEU A  42
SER A  17
ILE A  58
LEU A  28
 None
 1.07A 4qi9B-5a7yA:
undetectable		 4qi9B-5a7yA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 11 ILE A  82
LEU A  42
SER A  17
ILE A  58
LEU A  28
 None
 1.03A 4qleB-5a7yA:
undetectable		 4qleB-5a7yA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		3 / 3 LEU A 128
VAL A 112
ASP A 113
 None
 0.55A 5x23A-5a7yA:
undetectable		 5x23A-5a7yA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A 179
ILE A 209
VAL A 218
ASP A 220
ILE A 225
 SAH  A1291 (-4.3A)
SAH  A1291 (-4.0A)
SAH  A1291 (-4.6A)
SAH  A1291 ( 4.3A)
SAH  A1291 (-4.3A)
 0.76A 6emuB-5a7yA:
16.7		 6emuB-5a7yA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		7 / 12 LEU A 158
PRO A 160
ILE A 179
GLY A 180
ILE A 209
VAL A 218
ILE A 225
 SAH  A1291 (-4.0A)
SAH  A1291 (-3.8A)
SAH  A1291 (-4.3A)
SAH  A1291 (-3.7A)
SAH  A1291 (-4.0A)
SAH  A1291 (-4.6A)
SAH  A1291 (-4.3A)
 0.40A 6emuB-5a7yA:
16.7		 6emuB-5a7yA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		7 / 12 LEU A 158
PRO A 160
ILE A 179
GLY A 180
ILE A 209
VAL A 218
ILE A 225
 SAH  A1291 (-4.0A)
SAH  A1291 (-3.8A)
SAH  A1291 (-4.3A)
SAH  A1291 (-3.7A)
SAH  A1291 (-4.0A)
SAH  A1291 (-4.6A)
SAH  A1291 (-4.3A)
 0.38A 6emuC-5a7yA:
undetectable		 6emuC-5a7yA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE
(Sulfolobus
acidocaldarius) 		6 / 12 PRO A 160
ILE A 179
ILE A 209
VAL A 218
ASP A 220
ILE A 225
 SAH  A1291 (-3.8A)
SAH  A1291 (-4.3A)
SAH  A1291 (-4.0A)
SAH  A1291 (-4.6A)
SAH  A1291 ( 4.3A)
SAH  A1291 (-4.3A)
 0.72A 6emuC-5a7yA:
undetectable		 6emuC-5a7yA:
32.08