SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 9 SER A 253
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 FMN  A 339 (-3.4A)
FMN  A 339 (-3.2A)
FMN  A 339 (-2.9A)
FMN  A 339 (-4.9A)
FMN  A 339 (-4.4A)
 0.97A 1nb9A-5a89A:
14.5		 1nb9A-5a89A:
32.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 9 THR A 208
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 FMN  A 339 (-3.2A)
FMN  A 339 (-3.2A)
FMN  A 339 (-2.9A)
FMN  A 339 (-4.9A)
FMN  A 339 (-4.4A)
 0.80A 1nb9A-5a89A:
14.5		 1nb9A-5a89A:
32.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		6 / 11 THR A 208
VAL A 224
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 FMN  A 339 (-3.2A)
FMN  A 339 (-4.4A)
FMN  A 339 (-3.2A)
FMN  A 339 (-2.9A)
FMN  A 339 (-4.9A)
FMN  A 339 (-4.4A)
 0.56A 1t6zA-5a89A:
5.4		 1t6zA-5a89A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		6 / 11 THR A 208
VAL A 224
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 FMN  A 339 (-3.2A)
FMN  A 339 (-4.4A)
FMN  A 339 (-3.2A)
FMN  A 339 (-2.9A)
FMN  A 339 (-4.9A)
FMN  A 339 (-4.4A)
 0.70A 1t6zB-5a89A:
9.1		 1t6zB-5a89A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		4 / 4 LEU A 204
GLY A 205
GLY A 200
THR A 208
 None
None
ADP  A 501 ( 3.3A)
FMN  A 339 (-3.2A)
 0.97A 3si7A-5a89A:
undetectable		 3si7A-5a89A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 VAL A 254
SER A 266
VAL A 291
PHE A 287
LEU A 272
 None
 1.32A 4nc3A-5a89A:
undetectable		 4nc3A-5a89A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		4 / 4 VAL A 288
GLU A 286
GLY A 227
LEU A 318
 ZN  A 343 ( 4.8A)
None
None
None
 1.40A 5g5gC-5a89A:
undetectable		 5g5gC-5a89A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		3 / 3 SER A 269
LEU A 303
MET A 307
 None
FMN  A 339 (-4.9A)
FMN  A 339 (-4.3A)
 0.85A 5ikrB-5a89A:
undetectable		 5ikrB-5a89A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 ILE A 252
PRO A 220
GLU A 286
PHE A 287
GLY A 227
 None
 1.20A 5il1A-5a89A:
undetectable		 5il1A-5a89A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 ILE A 252
GLU A 286
PHE A 287
HIS A 325
GLY A 227
 None
None
None
ZN  A 343 (-3.3A)
None
 1.01A 5k7uA-5a89A:
undetectable		 5k7uA-5a89A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 ILE A 252
PRO A 220
GLU A 286
PHE A 287
GLY A 227
 None
 1.19A 5k7uA-5a89A:
undetectable		 5k7uA-5a89A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 MET A 242
LEU A 272
ALA A 250
PHE A 270
THR A 230
 None
None
None
ADP  A 501 ( 4.9A)
None
 1.21A 5k9dA-5a89A:
undetectable		 5k9dA-5a89A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF
(Corynebacterium
ammoniagenes) 		5 / 12 ILE A 252
GLU A 286
PHE A 287
HIS A 325
GLY A 227
 None
None
None
ZN  A 343 (-3.3A)
None
 0.97A 5l6eA-5a89A:
undetectable		 5l6eA-5a89A:
20.26