SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 168
VAL A 149
ILE A 192
ILE A 189
ILE A 128
 GOL  A1340 (-3.3A)
None
None
None
None
 0.78A 1c6yB-5a8dA:
undetectable		 1c6yB-5a8dA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  45
ILE A  75
ILE A  78
PRO A 136
ILE A 110
 GOL  A1340 (-3.6A)
None
None
None
GOL  A1340 (-4.2A)
 0.89A 1c6zA-5a8dA:
undetectable		 1c6zA-5a8dA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  45
ILE A  75
ILE A  78
PRO A 136
ILE A 110
 GOL  A1340 (-3.6A)
None
None
None
GOL  A1340 (-4.2A)
 0.94A 1c6zB-5a8dA:
undetectable		 1c6zB-5a8dA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 168
VAL A 149
ILE A 192
ILE A 189
ILE A 128
 GOL  A1340 (-3.3A)
None
None
None
None
 0.91A 1c6zB-5a8dA:
undetectable		 1c6zB-5a8dA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 LEU A 194
ALA A 177
VAL A 171
VAL A 111
 None
 0.79A 1epbB-5a8dA:
undetectable		 1epbB-5a8dA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 168
VAL A 149
ILE A 192
ILE A 189
ILE A 128
 GOL  A1340 (-3.3A)
None
None
None
None
 0.91A 2o4sA-5a8dA:
undetectable		 2o4sA-5a8dA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 168
VAL A 149
ILE A 192
ILE A 189
ILE A 128
 GOL  A1340 (-3.3A)
None
None
None
None
 0.89A 2pymB-5a8dA:
undetectable		 2pymB-5a8dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 168
VAL A 149
ILE A 192
ILE A 189
ILE A 128
 GOL  A1340 (-3.3A)
None
None
None
None
 0.84A 2q63B-5a8dA:
undetectable		 2q63B-5a8dA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  45
ILE A  75
ILE A  78
PRO A 136
ILE A 110
 GOL  A1340 (-3.6A)
None
None
None
GOL  A1340 (-4.2A)
 0.89A 2q64A-5a8dA:
undetectable		 2q64A-5a8dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 168
VAL A 149
ILE A 192
ILE A 189
ILE A 128
 GOL  A1340 (-3.3A)
None
None
None
None
 0.87A 2qakB-5a8dA:
undetectable		 2qakB-5a8dA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ALA A  45
ILE A  75
ILE A  78
PRO A 136
ILE A 110
 GOL  A1340 (-3.6A)
None
None
None
GOL  A1340 (-4.2A)
 1.00A 3ekxB-5a8dA:
undetectable		 3ekxB-5a8dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 7 PHE A 181
GLY A 168
MET A 208
PHE A 213
 None
GOL  A1340 (-3.3A)
None
None
 1.15A 3ko0D-5a8dA:
undetectable
3ko0E-5a8dA:
undetectable		 3ko0D-5a8dA:
11.96
3ko0E-5a8dA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  45
ILE A  75
ILE A  78
PRO A 136
ILE A 110
 GOL  A1340 (-3.6A)
None
None
None
GOL  A1340 (-4.2A)
 0.96A 3nduD-5a8dA:
undetectable		 3nduD-5a8dA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A  45
ILE A  75
ILE A  78
PRO A 136
ILE A 110
 GOL  A1340 (-3.6A)
None
None
None
GOL  A1340 (-4.2A)
 0.94A 3nu6A-5a8dA:
undetectable		 3nu6A-5a8dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLN A  38
HIS A 272
GLU A 242
GLU A 215
 None
 1.35A 3ql6A-5a8dA:
undetectable		 3ql6A-5a8dA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 241
VAL A 321
ILE A 307
LEU A  53
VAL A  48
 None
None
None
None
GOL  A1339 (-4.7A)
 1.18A 3w67C-5a8dA:
undetectable		 3w67C-5a8dA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A  35
PRO A  34
PHE A  36
PHE A 165
 None
 1.12A 4fgkA-5a8dA:
undetectable		 4fgkA-5a8dA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ASP A 166
ASP A  43
SER A 268
ALA A 231
 None
 1.18A 4nedA-5a8dA:
undetectable		 4nedA-5a8dA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLY A 168
VAL A 149
ILE A 192
ILE A 189
ILE A 128
 GOL  A1340 (-3.3A)
None
None
None
None
 0.95A 4njvC-5a8dA:
undetectable		 4njvC-5a8dA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A  45
ILE A  75
ILE A  78
PRO A 136
ILE A 110
 GOL  A1340 (-3.6A)
None
None
None
GOL  A1340 (-4.2A)
 0.98A 4njvD-5a8dA:
undetectable		 4njvD-5a8dA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ALA A  46
PRO A 167
GLY A 155
LEU A 194
 GOL  A1340 (-4.1A)
None
None
None
 0.98A 5eslA-5a8dA:
undetectable		 5eslA-5a8dA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 305
ALA A 274
VAL A 285
LEU A  83
LEU A 119
 None
GOL  A1340 (-3.0A)
None
None
None
 1.23A 5hv1A-5a8dA:
undetectable		 5hv1A-5a8dA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 MET A 310
ILE A 318
ALA A  45
ALA A 274
GLY A 168
 None
None
GOL  A1340 (-3.6A)
GOL  A1340 (-3.0A)
GOL  A1340 (-3.3A)
 1.09A 5igjA-5a8dA:
undetectable		 5igjA-5a8dA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 144
THR A 201
GLY A 146
PRO A 147
LEU A 148
 None
 1.44A 5jo9A-5a8dA:
undetectable		 5jo9A-5a8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ASP A  43
GLY A 122
PRO A 108
CYH A  57
 None
 1.28A 5nn8A-5a8dA:
undetectable		 5nn8A-5a8dA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5a8d CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ILE A  75
THR A  76
PRO A 108
 None
 0.44A 6ncsA-5a8dA:
undetectable		 6ncsA-5a8dA:
20.00